INT15358

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Context Info
Confidence 0.72
First Reported 1984
Last Reported 2010
Negated 1
Speculated 6
Reported most in Abstract
Documents 29
Total Number 36
Disease Relevance 10.43
Pain Relevance 16.94

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Ngf) extracellular space (Ngf) aging (Ngf)
extracellular region (Ngf) molecular_function (Ngf)
Anatomy Link Frequency
nerve 8
bladder 4
bowel 2
dorsal root ganglia 2
cortex 2
Ngf (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Nerve growth factor 611 100.00 Very High Very High Very High
substance P 22 100.00 Very High Very High Very High
Spinal nerve ligature 3 99.88 Very High Very High Very High
peripheral neuropathy 10 99.86 Very High Very High Very High
bDMF 4 99.80 Very High Very High Very High
Enkephalin 5 99.68 Very High Very High Very High
Inflammation 23 99.24 Very High Very High Very High
Thalamus 2 99.24 Very High Very High Very High
opioid receptor 6 98.60 Very High Very High Very High
Sciatic nerve 82 98.44 Very High Very High Very High
Disease Link Frequency Relevance Heat
Peripheral Neuropathy 10 99.86 Very High Very High Very High
INFLAMMATION 31 99.24 Very High Very High Very High
Injury 94 98.38 Very High Very High Very High
Nervous System Injury 51 97.52 Very High Very High Very High
Hypertrophy 4 97.36 Very High Very High Very High
Disease 57 97.24 Very High Very High Very High
Interstitial Cystitis 12 96.64 Very High Very High Very High
Ganglion Cysts 21 96.24 Very High Very High Very High
Overactive Bladder 5 95.96 Very High Very High Very High
Apoptosis 63 95.52 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The synthesis of mRNA of NGF in muscle was also confirmed following tetrodotoxin (TTX) blockade of sciatic nerve without denervation.
Transcription (synthesis) of NGF in sciatic nerve associated with tetrodotoxin, nerve growth factor and sciatic nerve
1) Confidence 0.72 Published 1991 Journal Neurosci. Lett. Section Abstract Doc Link 1724069 Disease Relevance 0 Pain Relevance 0.36
The dorsal root ganglia (DRGs) were sampled at various times throughout the experiment and processed for in situ hybridization to examine mRNA expression of the NGF receptors (p75 and trkA) and GAP-43.
Spec (examine) Transcription (expression) of NGF in DRGs
2) Confidence 0.71 Published 1998 Journal Exp. Neurol. Section Abstract Doc Link 9582251 Disease Relevance 0.16 Pain Relevance 0
The levels of NGF protein and mRNA in the bladder of PNL rats were significantly increased compared with sham rats.
Transcription (levels) of NGF protein in bladder associated with nerve growth factor
3) Confidence 0.69 Published 2008 Journal Am. J. Physiol. Regul. Integr. Comp. Physiol. Section Abstract Doc Link 18337317 Disease Relevance 1.34 Pain Relevance 0.42
In the absence of NGF, however, SP and cell numbers fell progressively after the second day.
Neg (absence) Transcription (absence) of NGF associated with nerve growth factor and substance p
4) Confidence 0.69 Published 1984 Journal Dev. Biol. Section Abstract Doc Link 6200374 Disease Relevance 0.12 Pain Relevance 0.96
The statistical analysis revealed that at week 4 after injury, there were significant differences in the number of myelinated axons among the groups of the control, NAT-NGF and LBD-NGF (n?
Transcription (groups) of LBD-NGF associated with nerve growth factor and injury
5) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2703785 Disease Relevance 0.39 Pain Relevance 0.68
The statistical analysis revealed that at week 4 after injury, there were significant differences in the number of myelinated axons among the groups of the control, NAT-NGF and LBD-NGF (n?
Transcription (groups) of NAT-NGF associated with nerve growth factor and injury
6) Confidence 0.69 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2703785 Disease Relevance 0.39 Pain Relevance 0.67
OBJECTIVES: To investigate the level of nerve growth factor (NGF) mRNA in bladder tissue and the effect of botulinum toxin A (BTX-A) treatment in patients with interstitial cystitis (IC).
Spec (investigate) Transcription (level) of nerve growth factor in bladder associated with nerve growth factor and interstitial cystitis
7) Confidence 0.68 Published 2007 Journal Urology Section Abstract Doc Link 17905097 Disease Relevance 0.25 Pain Relevance 0.33
OBJECTIVES: To investigate the level of nerve growth factor (NGF) mRNA in bladder tissue and the effect of botulinum toxin A (BTX-A) treatment in patients with interstitial cystitis (IC).
Spec (investigate) Transcription (level) of NGF in bladder associated with nerve growth factor and interstitial cystitis
8) Confidence 0.68 Published 2007 Journal Urology Section Abstract Doc Link 17905097 Disease Relevance 0.25 Pain Relevance 0.33
To assess NTs in the NuGr in PN, mRNA expression of BDNF, nerve growth factor (NGF), and NT receptors TrkA, TrkB, and p75 was determined 1 week after ligation of L5 and L6 spinal nerves (SNL).
Spec (determined) Transcription (expression) of nerve growth factor in nerve associated with nerve growth factor and peripheral neuropathy
9) Confidence 0.68 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15144880 Disease Relevance 0.47 Pain Relevance 0.57
To assess NTs in the NuGr in PN, mRNA expression of BDNF, nerve growth factor (NGF), and NT receptors TrkA, TrkB, and p75 was determined 1 week after ligation of L5 and L6 spinal nerves (SNL).
Spec (determined) Transcription (expression) of NGF in nerve associated with nerve growth factor and peripheral neuropathy
10) Confidence 0.68 Published 2004 Journal Exp. Neurol. Section Abstract Doc Link 15144880 Disease Relevance 0.47 Pain Relevance 0.57
The time course for NGF induction of mRNA and protein is similar, although the levels of mRNA increase approximately 5-fold, whereas the levels of receptor increase only 2-fold.
Transcription (induction) of NGF associated with nerve growth factor
11) Confidence 0.68 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7562535 Disease Relevance 0.16 Pain Relevance 0.64
Using RT-PCR, the mRNA level of nerve growth factor (NGF) was also detected.
Transcription (level) of NGF in nerve associated with nerve growth factor
12) Confidence 0.66 Published 2006 Journal Life Sci. Section Abstract Doc Link 16546221 Disease Relevance 0 Pain Relevance 0.56
Using RT-PCR, the mRNA level of nerve growth factor (NGF) was also detected.
Transcription (level) of nerve growth factor in nerve associated with nerve growth factor
13) Confidence 0.66 Published 2006 Journal Life Sci. Section Abstract Doc Link 16546221 Disease Relevance 0 Pain Relevance 0.56
Levels of NGF mRNA and protein are consistently detected in the hippocampal formation and cortex.
Transcription (Levels) of NGF mRNA in hippocampal formation associated with nerve growth factor
14) Confidence 0.65 Published 2010 Journal Mol Neurodegener Section Body Doc Link PMC2826326 Disease Relevance 0 Pain Relevance 0.44
Using RT-PCR, the mRNA level of nerve growth factor (NGF) was also detected.
Transcription (level) of NGF in nerve associated with nerve growth factor
15) Confidence 0.63 Published 2006 Journal Life Sci. Section Abstract Doc Link 16546221 Disease Relevance 0 Pain Relevance 0.56
The relative amount of mRNA in a tissue sample concentrated in Merkel cells was compared semiquantitatively to that from nearby tissue without Merkel cells. mRNAs for VIP, tyrosine hydroxylase, substance P were found in higher concentration in Merkel cells than in control tissues. mRNA for genes encoding pro-enkephalin, GAP-43, CGRP, NGF and BDNF were detected in the Merkel cell samples at concentration statistically equivalent to those found in the control tissues.
Transcription (detected) of NGF in Merkel cells associated with enkephalin and substance p
16) Confidence 0.62 Published 2000 Journal Life Sci. Section Abstract Doc Link 10794495 Disease Relevance 0 Pain Relevance 0.27
The down-regulation of nerve growth factor (NGF) mRNA and protein expression in the cortex and thalamus at defined time points between 1 and 24h after the propofol treatment, as well as a decrease of phosphorylated Akt were observed.
Transcription (expression) of NGF in nerve associated with nerve growth factor and thalamus
17) Confidence 0.59 Published 2009 Journal Int. J. Dev. Neurosci. Section Abstract Doc Link 19150648 Disease Relevance 0.51 Pain Relevance 0.30
ELISA analyses showed significant increases in NGF levels in L6-S1 dorsal root ganglia of NGF-treated rats.
Transcription (levels) of NGF in dorsal root ganglia associated with nerve growth factor
18) Confidence 0.53 Published 2006 Journal J. Neurosci. Section Abstract Doc Link 17050722 Disease Relevance 0.15 Pain Relevance 1.03
In this study we determined the intestinal expression of NGF mRNA by polymerase chain reaction and NGF by enzyme-linked immunosorbent assay.
Spec (determined) Transcription (expression) of NGF associated with nerve growth factor
19) Confidence 0.53 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12130729 Disease Relevance 0.70 Pain Relevance 0.59
NGF and NGF mRNA levels in the bowel were increased during inflammation.
Transcription (levels) of NGF in bowel associated with inflammation and nerve growth factor
20) Confidence 0.53 Published 2002 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 12130729 Disease Relevance 0.80 Pain Relevance 0.74

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