INT153582

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Context Info
Confidence 0.01
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 3
Disease Relevance 0
Pain Relevance 1.87

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Oprm1, Hint1) signal transduction (Oprm1) nucleus (Hint1)
cytoplasm (Hint1) signal transducer activity (Oprm1)
Anatomy Link Frequency
neurons 2
Oprm1 (Mus musculus)
Hint1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
opioid receptor 21 100.00 Very High Very High Very High
Kinase C 3 100.00 Very High Very High Very High
Morphine 9 99.04 Very High Very High Very High
Intracerebroventricular 3 98.38 Very High Very High Very High
Analgesic 3 84.80 Quite High
mu opioid receptor 3 75.00 Quite High
nMDA receptor 3 26.40 Quite Low
antagonist 3 25.00 Low Low

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In neurons, the C terminus of the Mu-opioid receptor (MOR) binds to the protein kinase C-interacting protein/histidine triad nucleotide binding protein 1 (PKCI/HINT1) which in turn binds the regulator of G-protein signalling RGSZ1/Z2 (RGSZ) protein.
MOR Binding (binds) of HINT1 in neurons associated with kinase c and opioid receptor
1) Confidence 0.01 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18652891 Disease Relevance 0 Pain Relevance 0.59
In neurons, the C terminus of the Mu-opioid receptor (MOR) binds to the protein kinase C-interacting protein/histidine triad nucleotide binding protein 1 (PKCI/HINT1) which in turn binds the regulator of G-protein signalling RGSZ1/Z2 (RGSZ) protein.
Mu-opioid receptor Binding (binds) of HINT1 in neurons associated with kinase c and opioid receptor
2) Confidence 0.01 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18652891 Disease Relevance 0 Pain Relevance 0.59
In this study, we found that intracerebroventricular (icv) administration of morphine recruits PKC isoforms, mostly PKCgamma, to the MOR via the HINT1/RGSZ complex.
MOR Binding (complex) of HINT1 associated with opioid receptor, intracerebroventricular and morphine
3) Confidence 0.01 Published 2008 Journal Cell. Signal. Section Abstract Doc Link 18652891 Disease Relevance 0 Pain Relevance 0.69

General Comments

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