INT153606

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Context Info
Confidence 0.69
First Reported 2004
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.23
Pain Relevance 1.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Pde4a) nucleus (Pde4a) cytoplasm (Pde4a)
Anatomy Link Frequency
lung 1
Pde4a (Mus musculus)
Pain Link Frequency Relevance Heat
agonist 1 99.88 Very High Very High Very High
Endogenous opioid 2 99.70 Very High Very High Very High
Inflammation 40 99.36 Very High Very High Very High
Hyperalgesia 1 98.24 Very High Very High Very High
analgesia 4 97.60 Very High Very High Very High
opioid receptor 6 95.16 Very High Very High Very High
MU agonist 2 93.12 High High
Analgesic 3 88.12 High High
Thermal hyperalgesia 2 75.00 Quite High
Opioid 3 69.96 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 41 99.36 Very High Very High Very High
Cardiovascular Disease 1 99.34 Very High Very High Very High
Pulmonary Disease 1 98.84 Very High Very High Very High
Reprotox - General 2 2 98.26 Very High Very High Very High
Hyperalgesia 4 98.24 Very High Very High Very High
Disease 5 90.32 High High
Nociception 1 78.88 Quite High
Asthma 13 67.12 Quite High
Hypersensitivity 3 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Cotreatment with a low subanalgesic dose of kelatorphan, an inhibitor of multiple endogenous opioid peptide-degrading enzymes, stabilizes endogenous opioid agonists released by cAMP-PDE inhibitors, resulting in conversion of the hyperalgesia to analgesia without requiring selective blockade of excitatory opioid receptor signaling.
Localization (sed by c) of cAMP-PDE associated with hyperalgesia, agonist, endogenous opioid, opioid receptor and analgesia
1) Confidence 0.69 Published 2008 Journal Brain Res. Section Abstract Doc Link 18656459 Disease Relevance 0.34 Pain Relevance 1.57
Sildenafil, a PDE 5 inhibitor is used for the treatment of sexual dysfunction and may potentially be used in cardiovascular disease [30], and there is the imminent release of new PDE 4 inhibitors for inflammatory lung disease [11,31].
Localization (release) of PDE 4 in lung associated with reprotox - general 2, pulmonary disease, inflammation and cardiovascular disease
2) Confidence 0.53 Published 2004 Journal Respir Res Section Body Doc Link PMC419478 Disease Relevance 0.90 Pain Relevance 0.22

General Comments

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