INT153610

Context Info Confidence 0.49 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 3.04 Pain Relevance 0.44

signal transduction (SPN) extracellular space (SPN) plasma membrane (SPN)

Anatomy Link Frequency SPN 1 mononuclear cells 1 SPN (Homo sapiens)

Pain Link Frequency Relevance Heat positron emission tomography 186 100.00 Pain 1 83.72 cva 28 82.44 headache 3 31.12 imagery 25 5.00 Thoracotomy 8 5.00 palliative 5 5.00 Neurotransmitter 1 5.00 pruritus 1 5.00 Dopamine 1 5.00

Disease Link Frequency Relevance Heat Urological Neuroanatomy 4 100.00 Myeloid Sarcoma 6 98.60 Metastasis 42 98.52 Pulmonary Coin Lesion 8 91.32 Pancytopenia 1 90.64 Nicotine Addiction 2 88.92 Non-small-cell Lung Cancer 39 85.52 Hyperplasia 1 85.04 Adverse Drug Reaction 6 84.20 Pain 1 83.72

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Subsequent histopathology disclosed sheets of mononuclear cells in the orbital mass, and immunohistochemical stains demonstrated positive results for myeloperoxidase and CD43, which supported the diagnosis of granulocytic sarcoma (GS).

Positive_regulation (results) of CD43 in mononuclear cells associated with myeloid sarcoma

1) Confidence 0.49 Published 2008 Journal Cancer Genet. Cytogenet. Section Abstract Doc Link 18656695 Disease Relevance 1.04 Pain Relevance 0.08

Eight studies were identified that evaluated the cost-effectiveness of PET for SPN characterization.

Positive_regulation (effectiveness) of SPN associated with positron emission tomography and urological neuroanatomy

2) Confidence 0.13 Published 2010 Journal BMC Health Serv Res Section Body Doc Link PMC2959014 Disease Relevance 0.32 Pain Relevance 0.24

In May 2009 CT demonstrated the SPN increased in size with multiple lung and ribs metastasis (Fig. 1A).

Positive_regulation (increased) of SPN in SPN associated with urological neuroanatomy and metastasis

3) Confidence 0.10 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2843670 Disease Relevance 1.68 Pain Relevance 0.11

General Comments

This test has worked.