INT153611

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Context Info
Confidence 0.86
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 1.00
Pain Relevance 2.09

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Mgll) lipid metabolic process (Mgll)
Mgll (Mus musculus)
Pain Link Frequency Relevance Heat
Endocannabinoid 21 99.36 Very High Very High Very High
analgesia 2 97.20 Very High Very High Very High
Cannabinoid receptor 10 95.88 Very High Very High Very High
Inflammation 4 93.08 High High
tolerance 2 93.04 High High
Opioid 1 91.60 High High
Cannabinoid 6 91.12 High High
Analgesic 4 90.24 High High
Multiple sclerosis 7 88.72 High High
cytokine 3 87.20 High High
Disease Link Frequency Relevance Heat
Hypothermia 1 98.44 Very High Very High Very High
INFLAMMATION 4 93.08 High High
Demyelinating Disease 8 88.72 High High
Drug Dependence 1 73.68 Quite High
Pain 2 71.28 Quite High
Appetite Loss 1 71.04 Quite High
Sprains And Strains 14 5.00 Very Low Very Low Very Low
Obesity 1 5.00 Very Low Very Low Very Low
Disseminated Intravascular Coagulation 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
We found that a similar form of functional antagonism was produced by sustained inactivation of monoacylglycerol lipase (MAGL), the principal degradative enzyme for the endocannabinoid 2-arachidonoylglycerol.
Protein_catabolism (degradative) of MAGL associated with endocannabinoid
1) Confidence 0.86 Published 2010 Journal Nat. Neurosci. Section Abstract Doc Link 20729846 Disease Relevance 0.07 Pain Relevance 0.72
These changes were not due to differences in the expression of the degradation enzymes, fatty acid amide hydrolase and monoacylglycerol lipase, or of biosynthetic enzymes, diacylglycerol lipase-alpha and N-acylphosphatidylethanolamine phospholipase-D at this time (60 days).
Protein_catabolism (degradation) of monoacylglycerol lipase
2) Confidence 0.57 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18657182 Disease Relevance 0.61 Pain Relevance 0.82
These observations indicate that MGL degrades 2-AG and hence plays an important role in EC signaling.
Protein_catabolism (degrades) of MGL associated with endocannabinoid
3) Confidence 0.22 Published 2010 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2911655 Disease Relevance 0.31 Pain Relevance 0.56

General Comments

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