INT153616

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Context Info
Confidence 0.50
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 12
Disease Relevance 2.72
Pain Relevance 3.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (Mgll) lipid metabolic process (Mgll)
Anatomy Link Frequency
microglia 1
Mgll (Mus musculus)
Pain Link Frequency Relevance Heat
Cannabinoid 52 98.70 Very High Very High Very High
Endocannabinoid 161 97.56 Very High Very High Very High
Inflammation 52 93.80 High High
Multiple sclerosis 7 89.44 High High
cytokine 5 87.92 High High
Neuropathic pain 38 87.32 High High
Spinal cord 34 86.12 High High
Cannabinoid receptor 60 82.08 Quite High
Pain 47 74.92 Quite High
Spinal sensitization 2 73.60 Quite High
Disease Link Frequency Relevance Heat
Sprains And Strains 112 98.88 Very High Very High Very High
INFLAMMATION 56 93.80 High High
Demyelinating Disease 8 89.44 High High
Neuropathic Pain 65 87.32 High High
Pain 66 74.92 Quite High
Nervous System Injury 11 58.88 Quite High
Neurological Disease 1 57.92 Quite High
Post Operative Pain 1 53.04 Quite High
Appetite Loss 8 48.48 Quite Low
Hypersensitivity 5 43.04 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These changes were not due to differences in the expression of the degradation enzymes, fatty acid amide hydrolase and monoacylglycerol lipase, or of biosynthetic enzymes, diacylglycerol lipase-alpha and N-acylphosphatidylethanolamine phospholipase-D at this time (60 days).
Gene_expression (expression) of monoacylglycerol lipase
1) Confidence 0.50 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18657182 Disease Relevance 0.61 Pain Relevance 0.85
Hydrolysing enzymes include fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL) and N-acylethanolamine-hydrolysing acid amidase (NAAA).
Gene_expression (include) of MAGL
2) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2770047 Disease Relevance 0.48 Pain Relevance 0.76
Hydrolysing enzymes include fatty acid amide hydrolase (FAAH), monoacylglycerol lipase (MAGL) and N-acylethanolamine-hydrolysing acid amidase (NAAA).
Gene_expression (include) of monoacylglycerol lipase
3) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2770047 Disease Relevance 0.48 Pain Relevance 0.76
MGL is a member of the serine hydrolase family and ubiquitously expressed [6].
Gene_expression (expressed) of MGL
4) Confidence 0.19 Published 2010 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2911655 Disease Relevance 0 Pain Relevance 0.12
Compared to the wild-type control, MAG levels were increased 5-fold in Yju3-deficient cells, which decreased to wild-type levels upon heterologous expression of murine MGL.
Gene_expression (expression) of MGL
5) Confidence 0.17 Published 2010 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2911655 Disease Relevance 0.06 Pain Relevance 0
Yju3p deficiency causes MAG accumulation in vitro and can be complemented by the expression of murine MGL
Gene_expression (expression) of MGL
6) Confidence 0.17 Published 2010 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2911655 Disease Relevance 0.22 Pain Relevance 0
Next, we introduced murine MGL for heterologous expression into the yju3?
Gene_expression (expression) of MGL
7) Confidence 0.17 Published 2010 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2911655 Disease Relevance 0.10 Pain Relevance 0
Subcellular distribution of Yju3p activity and heterologous expression of murine MGL in yeast
Gene_expression (expression) of MGL
8) Confidence 0.17 Published 2010 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2911655 Disease Relevance 0 Pain Relevance 0
Overexpression of murine MGL in the yju3?
Gene_expression (Overexpression) of MGL
9) Confidence 0.15 Published 2010 Journal Biochimica et Biophysica Acta Section Body Doc Link PMC2911655 Disease Relevance 0.26 Pain Relevance 0
Loss of this activity was restored by heterologous expression of murine monoglyceride lipase (MGL).
Gene_expression (expression) of MGL
10) Confidence 0.15 Published 2010 Journal Biochimica et Biophysica Acta Section Abstract Doc Link PMC2911655 Disease Relevance 0 Pain Relevance 0.04
Loss of this activity was restored by heterologous expression of murine monoglyceride lipase (MGL).
Gene_expression (expression) of monoglyceride lipase
11) Confidence 0.13 Published 2010 Journal Biochimica et Biophysica Acta Section Abstract Doc Link PMC2911655 Disease Relevance 0 Pain Relevance 0.04
Accordingly, BV-2 and primary microglia also have different cannabinoid enzymatic profiles; i.e. primary microglia, but not BV-2 cells, express monoacylglycerol lipase [48,49].
Gene_expression (express) of monoacylglycerol lipase in microglia associated with cannabinoid
12) Confidence 0.03 Published 2009 Journal Mol Pain Section Body Doc Link PMC2704199 Disease Relevance 0.52 Pain Relevance 0.46

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