INT15362

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Context Info
Confidence 0.21
First Reported 1991
Last Reported 2000
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 2.47
Pain Relevance 0.83

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Cela1) extracellular region (Cela1)
Anatomy Link Frequency
Plasma 1
Cela1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 4 96.36 Very High Very High Very High
Chronic pancreatitis 6 88.04 High High
alcohol 3 87.60 High High
Disease Link Frequency Relevance Heat
Exocrine Pancreatic Insufficiency 1 98.60 Very High Very High Very High
Pancreatitis 12 96.16 Very High Very High Very High
Recurrence 4 96.04 Very High Very High Very High
Gallstones 1 95.28 Very High Very High Very High
Diabetes Mellitus 9 94.64 High High
Hepatocellular Cancer 1 93.88 High High
Stomach Cancer 1 93.48 High High
Disease 5 92.56 High High
Diabetes Complications 1 59.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Reduced faecal elastase-1 concentrations were found in 56.7% of type 1 patients, 35% of type 2 patients and 18.1% of the controls.
Negative_regulation (Reduced) of elastase-1
1) Confidence 0.21 Published 2000 Journal Acta Diabetol Section Abstract Doc Link 11277309 Disease Relevance 0.74 Pain Relevance 0.04
Over time, we found a significant (p = 0.000002) reduction in elastase-1 levels.
Negative_regulation (reduction) of elastase-1
2) Confidence 0.03 Published 1991 Journal Int. J. Pancreatol. Section Abstract Doc Link 1724259 Disease Relevance 0.38 Pain Relevance 0.27
The reduction of serum elastase-1 was significantly (p less than 0.003) more frequent in patients presenting a reduction in painful relapses than in patients with a stable or increased attach rate; this association was weaker (p less than 0.05) for lipase and trypsin, and absent for amylase.
Negative_regulation (reduction) of elastase-1 associated with pain and recurrence
3) Confidence 0.03 Published 1991 Journal Int. J. Pancreatol. Section Abstract Doc Link 1724259 Disease Relevance 0.38 Pain Relevance 0.28
Plasma MTLS values showed low correlation with serum trypsin, elastase 1, pancreatic amylase, lipase, and pancreatic secretory trypsin inhibitor (PSTI).
Negative_regulation (inhibitor) of elastase 1 in Plasma
4) Confidence 0.01 Published 1996 Journal J. Clin. Lab. Anal. Section Abstract Doc Link 8951609 Disease Relevance 0.97 Pain Relevance 0.25

General Comments

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