INT153629

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Context Info
Confidence 0.12
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.33
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CHKA) lipid metabolic process (CHKA) cytoplasm (CHKA)
signal transducer activity (CHKA)
CHKA (Homo sapiens)
Pain Link Frequency Relevance Heat
agonist 16 97.84 Very High Very High Very High
Morphine 3 96.32 Very High Very High Very High
withdrawal 1 94.08 High High
Opioid 4 93.64 High High
fibrosis 8 90.92 High High
opioid receptor 3 81.76 Quite High
opiate 1 49.72 Quite Low
narcan 1 25.00 Low Low
Pain 1 18.88 Low Low
nud 1 17.88 Low Low
Disease Link Frequency Relevance Heat
Carcinoma 6 98.00 Very High Very High Very High
Cancer 41 95.28 Very High Very High Very High
Opiate Addiction 1 94.08 High High
Hemangioma 2 93.44 High High
Cirrhosis 18 91.44 High High
Necrosis 2 91.44 High High
Fibrosis 6 90.92 High High
Rhinitis 1 87.80 High High
Bordatella Infection 1 81.12 Quite High
Cv Unclassified Under Development 1 78.24 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In scattered areas, cells were immunochemically positive for cytokeratin (CK) 7 and negative for CK 20.
Negative_regulation (positive) of CK
1) Confidence 0.12 Published 2007 Journal World J Surg Oncol Section Body Doc Link PMC2246133 Disease Relevance 1.79 Pain Relevance 0.05
increase in the mRNA and protein expression of the Cyclin-dependent kinase inhibitor (Cki) p21waf1/cip1 and also an increase in protein expression only of p27kip1, another CKi.
Negative_regulation (kinase inhibitor) of Cki
2) Confidence 0.08 Published 2008 Journal PPAR Research Section Body Doc Link PMC2396389 Disease Relevance 0.18 Pain Relevance 0.06
Sufentanil reduced CKI protein and kinase activity in the cytosol (30-37%).
Negative_regulation (educed ) of CKI protein
3) Confidence 0.00 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18657552 Disease Relevance 0.36 Pain Relevance 0.81

General Comments

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