INT15363

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Context Info
Confidence 0.78
First Reported 1987
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 10
Total Number 10
Disease Relevance 3.22
Pain Relevance 1.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CELA1) extracellular region (CELA1)
Anatomy Link Frequency
pancreas 1
acinar cells 1
bowel 1
brush 1
CELA1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 11 98.80 Very High Very High Very High
Bioavailability 1 97.48 Very High Very High Very High
alcohol 3 96.72 Very High Very High Very High
abdominal pain 2 96.12 Very High Very High Very High
Pain 7 87.96 High High
Disease Link Frequency Relevance Heat
Adenocarcinoma 1 99.76 Very High Very High Very High
Pancreatitis 25 98.80 Very High Very High Very High
Abdominal Pain 2 96.12 Very High Very High Very High
Exocrine Pancreatic Insufficiency 5 93.36 High High
Disease 3 90.24 High High
Pancreatic Cancer 3 89.04 High High
Carcinoma 2 88.96 High High
Recurrence 6 88.28 High High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 75.00 Quite High
Cancer 4 73.84 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Pancreatic elastase-1 is a proteolytic enzyme exclusively produced in the pancreas, is stable when passing through the bowel, and its determination is associated with chronic pancreatitis.
Gene_expression (produced) of elastase-1 in bowel associated with chronic pancreatitis
1) Confidence 0.78 Published 2008 Journal J. Clin. Lab. Anal. Section Abstract Doc Link 18623102 Disease Relevance 0.26 Pain Relevance 0.10
Pancreatic elastase-1 is a specific human protease synthetized by the acinar cells.
Gene_expression (synthetized) of elastase-1 in acinar cells
2) Confidence 0.46 Published 2002 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 12059069 Disease Relevance 0.06 Pain Relevance 0.06
Immunoreactive elastase-1 cannot be detected in either porcine or bovine pancreatic enzyme preparations.
Gene_expression (detected) of elastase-1
3) Confidence 0.41 Published 2002 Journal Clin. Chem. Lab. Med. Section Abstract Doc Link 12059069 Disease Relevance 0.06 Pain Relevance 0.06
All patients' elastase-1 concentrations and chymotrypsin activities [fecal chymotrypsin test (FCT)] were measured, and the serum pancreolauryl test (PLT) was performed.
Gene_expression (concentrations) of elastase-1
4) Confidence 0.30 Published 1995 Journal Am. J. Gastroenterol. Section Body Doc Link 7572904 Disease Relevance 0.09 Pain Relevance 0
[Assay of serum elastase 1 in adenocarcinoma of the pancreas: diagnostic value, compared and combined study with serum CEA and CA 19-9].
Gene_expression ([Assay) of elastase in pancreas associated with adenocarcinoma
5) Confidence 0.02 Published 1988 Journal Gastroenterol. Clin. Biol. Section Title Doc Link 3166429 Disease Relevance 0.71 Pain Relevance 0.09
This presystemic metabolism in the gastrointestinal tract is based on luminally secreted enzymes (I) including pepsins, trypsin, chymotrypsin, elastase and carboxypeptidase A/B, on brush border membrane bound enzymes (II) including various carboxypeptidases and aminopeptidases and on cytosolic enzymes (III).
Gene_expression (based) of elastase in brush
6) Confidence 0.02 Published 2007 Journal Curr. Drug Metab. Section Abstract Doc Link 17584022 Disease Relevance 0 Pain Relevance 0.14
Most patients with chronic pancreatitis studied during clinical remission (39 out of 43) had serum elastase levels either within (n = 24) or below (n = 15) the control range.
Gene_expression (levels) of elastase associated with chronic pancreatitis
7) Confidence 0.01 Published 1987 Journal Br J Surg Section Abstract Doc Link 2435358 Disease Relevance 0.82 Pain Relevance 0.34
Elastase was slightly raised in two, whereas amylase and pancreatic isoamylase were elevated in seven and eight, respectively.
Gene_expression (raised) of Elastase
8) Confidence 0.01 Published 1987 Journal Br J Surg Section Abstract Doc Link 2435358 Disease Relevance 0.65 Pain Relevance 0.30
In patients with severe exocrine impairment, low levels of elastase were found in only 20% of the cases, whereas trypsin and lipase were reduced in 73.3 and 53.3% of the cases, respectively.
Gene_expression (found) of elastase
9) Confidence 0.00 Published 1991 Journal Int. J. Pancreatol. Section Abstract Doc Link 1724259 Disease Relevance 0.29 Pain Relevance 0.26
In patients with severe exocrine impairment, low levels of elastase were found in only 20% of the cases, whereas trypsin and lipase were reduced in 73.3 and 53.3% of the cases, respectively.
Gene_expression (levels) of elastase
10) Confidence 0.00 Published 1991 Journal Int. J. Pancreatol. Section Abstract Doc Link 1724259 Disease Relevance 0.29 Pain Relevance 0.26

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