INT153649

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Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 0.38
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (ASIC1) transport (ASIC1) plasma membrane (ASIC1)
Anatomy Link Frequency
plasma 2
ASIC1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 2 98.60 Very High Very High Very High
ASIC 24 98.20 Very High Very High Very High
Glutamate 1 86.40 High High
Pain 3 83.68 Quite High
Multiple sclerosis 2 74.28 Quite High
imagery 3 5.00 Very Low Very Low Very Low
Dopamine 2 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
ischemia 1 5.00 Very Low Very Low Very Low
nMDA receptor 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Pain 3 83.68 Quite High
Demyelinating Disease 2 74.28 Quite High
Stroke 1 73.36 Quite High
Neurological Disease 2 72.16 Quite High
Death 8 5.00 Very Low Very Low Very Low
Toxicity 6 5.00 Very Low Very Low Very Low
Disease 5 5.00 Very Low Very Low Very Low
Acidosis 4 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Apoptosis 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Diminazene blocked ASIC1a, -1b -2a, and -3 currents expressed in CHO cells with a rank order of potency 1b > 3 > 2a >or= 1a.
Negative_regulation (blocked) of Gene_expression (expressed) of ASIC1a associated with potency
1) Confidence 0.42 Published 2010 Journal Neuropharmacology Section Abstract Doc Link 20114056 Disease Relevance 0.29 Pain Relevance 0.48
We therefore asked whether the effect of PICK1 on ASIC1a surface expression is also dependent on the BAR domain of PICK1.
Spec (whether) Negative_regulation (effect) of Gene_expression (expression) of ASIC1a
2) Confidence 0.35 Published 2010 Journal Mol Brain Section Body Doc Link PMC3018362 Disease Relevance 0 Pain Relevance 0.04
We demonstrate here that transfected ASIC4 is targeted to the plasma membrane in CHO-K1 cells, where it associates with ASIC1a and downregulates exogenous ASIC1a expression.
Negative_regulation (downregulates) of Gene_expression (expression) of ASIC1a in plasma
3) Confidence 0.31 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18662336 Disease Relevance 0.08 Pain Relevance 0.27

General Comments

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