INT153666

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Context Info
Confidence 0.77
First Reported 2004
Last Reported 2010
Negated 1
Speculated 5
Reported most in Body
Documents 156
Total Number 162
Disease Relevance 120.99
Pain Relevance 3.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CAV1) mitochondrion (CAV1) small molecule metabolic process (CAV1)
Golgi apparatus (CAV1) endoplasmic reticulum (CAV1) intracellular (CAV1)
Anatomy Link Frequency
HPAF-II 9
BxPC-3 7
epithelium 7
nucleus pulposus 5
margins 3
CAV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 23 99.24 Very High Very High Very High
Inflammation 292 97.36 Very High Very High Very High
backache 360 94.96 High High
cytokine 241 94.56 High High
fibrosis 58 92.56 High High
Calcium channel 14 92.04 High High
cINOD 2 86.16 High High
Osteoarthritis 173 81.04 Quite High
adenocard 1 75.00 Quite High
Angina 4 74.72 Quite High
Disease Link Frequency Relevance Heat
Cancer 5553 100.00 Very High Very High Very High
Aging 2806 100.00 Very High Very High Very High
Malignant Neoplastic Disease 342 100.00 Very High Very High Very High
Adhesions 148 100.00 Very High Very High Very High
Targeted Disruption 190 99.98 Very High Very High Very High
Prostate Cancer 4233 99.96 Very High Very High Very High
Carcinoma 66 99.96 Very High Very High Very High
Adenocarcinoma 3003 99.84 Very High Very High Very High
Breast Cancer 204 99.84 Very High Very High Very High
Stress 722 99.80 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In mouse NIH 3T3 fibroblasts, administration of subcytotoxic levels of H2O2 to experimentally mimic oxidative stress induced cellular senescence and increased caveolin-1 expression.
Gene_expression (expression) of caveolin-1 in fibroblasts associated with stress and aging
1) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 1.22 Pain Relevance 0
Expression of caveolin-3 is muscle-specific, whereas caveolin-1 and caveolin-2 are coexpressed in many cell types [26].
Gene_expression (coexpressed) of caveolin-1 in muscle
2) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 0.80 Pain Relevance 0.17
Moreover, we demonstrate a correlation between caveolin-1 and p16INK4a gene expression. p16INK4a is a cyclin-dependent kinase inhibitor that prevents retinoblastoma phosphorylation and arrests the cell cycle in the G0/G1 phase prior to entry into the synthesis phase [53,54].
Gene_expression (expression) of caveolin-1 associated with retinoblastoma
3) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 0.91 Pain Relevance 0.05
In human endothelial cells, isolated from atherosclerotic patients and induced to senesce, caveolin-1 expression was correlated with senescence biomarkers and with expression of 4-hydroxynonenal expression (a marker of lipid peroxidation and thus oxidative stress) independently of an effect on telomere length [31].
Gene_expression (expression) of caveolin-1 in endothelial cells associated with stress, aging and atherosclerosis
4) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 1.30 Pain Relevance 0
Gene expression for caveolin-1 was detected in the NP tissue of every sample analysed (qRT-PCR analysis).
Gene_expression (expression) of caveolin-1
5) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 0 Pain Relevance 0
A negative correlation was observed between gene expression for caveolin-1 and age of the donor (P = 0.0472) (Figure 2b).


Gene_expression (expression) of caveolin-1
6) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 0 Pain Relevance 0
The literature describes evidence linking cell exposure to stressful stimuli to both caveolin-1 expression and cellular senescence.
Gene_expression (expression) of caveolin-1 associated with aging
7) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 1.04 Pain Relevance 0
Administration of H2O2 to these chondrocytes induced cellular senescence via expression of the caveolin-1 protein, a mechanism reversed by antisense oligonucleotide-mediated downregulation of the caveolin-1 gene [19].
Gene_expression (expression) of caveolin-1 protein in chondrocytes associated with aging
8) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 1.35 Pain Relevance 0.16
To investigate gene expression of caveolin-1 in human NP cells, RNA was extracted from isolated cells following the standard procedure for TRIzol® reagent (Invitrogen). cDNA was then synthesised using Superscript II in accordance with the instructions of the manufacturer (Invitrogen).
Gene_expression (expression) of caveolin-1
9) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 0 Pain Relevance 0
Quantitative real-time reverse transcription-PCR (qRT-PCR) was performed to further examine caveolin-1 gene expression in human NP cells and to investigate any correlation between caveolin-1 and p16INK4a gene expression in isolated NP cells using the standard curve method of analysis as described previously [18].
Gene_expression (expression) of caveolin-1
10) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 0 Pain Relevance 0
Here, we show that caveolin-1 gene expression and protein expression are increased during IVD degeneration, but not in a manner that is associated with increasing chronological age.
Gene_expression (expression) of caveolin-1 gene
11) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 0.91 Pain Relevance 0.06
Immunohistochemical detection of caveolin-1 protein in human nucleus pulposus
Gene_expression (detection) of caveolin-1 protein in nucleus pulposus
12) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 0 Pain Relevance 0
Caveolin-1 protein expression was investigated in 28 IVD samples (for sample details, see Table 2).
Gene_expression (expression) of Caveolin-1 protein
13) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 0 Pain Relevance 0
Comparison of caveolin-1 gene expression by non-degenerate and degenerate samples demonstrated higher gene expression in degenerate samples (conventional RT-PCR analysis, Figure 1).
Gene_expression (expression) of caveolin-1 gene
14) Confidence 0.77 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 0 Pain Relevance 0
That same group also demonstrated that ectopic re-expression of cav-1 decreased Erk activation in Ras-transformed CHO cells [39].
Gene_expression (expression) of cav-1
15) Confidence 0.74 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.24 Pain Relevance 0.04
It is possible that biphasic expression of cav-1; meaning, overexpression in primary tumors and low or absent expression in metastases occurs in pancreatic cancer.
Gene_expression (expression) of cav-1 associated with cancer, pancreatic cancer and metastasis
16) Confidence 0.74 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.78 Pain Relevance 0
Figure 1C demonstrates that ectopic re-expression of cav-1 to levels similar to that of the BxPC-3 cells significantly decreases HPAF-II migration (890 ± 67 square pixels; p = 0.0032) compared with the untransfected or GFP-vector control HPAF-II cells (1630 ± 183 and 1435 ± 235 square pixels, respectively).
Gene_expression (expression) of cav-1 in BxPC-3
17) Confidence 0.74 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.06 Pain Relevance 0
Levels of active Erk and p38 MAPK were assessed in the HPAF-II/GFP-cav-1 transfectants.
Gene_expression (transfectants) of GFP-cav-1 in HPAF-II
18) Confidence 0.74 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.17 Pain Relevance 0
These results suggest that high cav-1 expression may be associated with primary tumors, while loss of cav-1 may be associated with metastases.
Gene_expression (expression) of cav-1 associated with cancer and metastasis
19) Confidence 0.74 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.26 Pain Relevance 0.05
Two recent studies have demonstrated a biphasic expression of cav-1 in primary vs. metastatic tumors [48,49].
Gene_expression (expression) of cav-1 associated with metastasis
20) Confidence 0.74 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.64 Pain Relevance 0

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