INT153667

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Context Info
Confidence 0.76
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 15
Disease Relevance 11.92
Pain Relevance 0.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CAV1) mitochondrion (CAV1) small molecule metabolic process (CAV1)
Golgi apparatus (CAV1) endoplasmic reticulum (CAV1) intracellular (CAV1)
Anatomy Link Frequency
epithelial cells 6
blood 2
HPAF-II 1
CAV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 9 97.00 Very High Very High Very High
Inflammation 13 91.32 High High
Osteoarthritis 64 75.00 Quite High
adenocard 1 75.00 Quite High
cytokine 3 51.76 Quite High
Angina 1 51.08 Quite High
Pain 11 5.00 Very Low Very Low Very Low
positron emission tomography 10 5.00 Very Low Very Low Very Low
Potency 10 5.00 Very Low Very Low Very Low
imagery 10 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Metastasis 196 99.88 Very High Very High Very High
Prostate Cancer 990 99.62 Very High Very High Very High
Cancer 933 99.24 Very High Very High Very High
Apoptosis 51 98.60 Very High Very High Very High
Recurrence 190 97.52 Very High Very High Very High
Malignant Neoplastic Disease 80 97.08 Very High Very High Very High
Adenocarcinoma 102 94.16 High High
INFLAMMATION 11 91.32 High High
Targeted Disruption 22 89.20 High High
Adhesions 22 88.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Secreted Cav-1 can be reproducibly detected in peripheral blood using a sensitive and specific immunoassay.
Localization (Secreted) of Cav-1 in blood
1) Confidence 0.76 Published 2010 Journal Cancer management and research Section Abstract Doc Link PMC3004586 Disease Relevance 0.84 Pain Relevance 0
Cav-1 is also secreted as a biologically active molecule that promotes cell survival and angiogenesis within the tumor microenvironment.
Localization (secreted) of Cav-1 associated with cancer
2) Confidence 0.76 Published 2010 Journal Cancer management and research Section Abstract Doc Link PMC3004586 Disease Relevance 0.86 Pain Relevance 0
Thus, secreted Cav-1 is a promising biomarker in identifying clinically significant prostate cancer.



Localization (secreted) of Cav-1 associated with prostate cancer
3) Confidence 0.76 Published 2010 Journal Cancer management and research Section Abstract Doc Link PMC3004586 Disease Relevance 0.76 Pain Relevance 0
CD), which sequesters cholesterol, disrupts caveolae and mis-localizes cav-1 in the cell [43].
Localization (localizes) of cav-1
4) Confidence 0.72 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.22 Pain Relevance 0
To determine if cav-1 expression affected RhoC activation, levels of GTP-bound RhoC was measured in the GFP-cav-1 and control HPAF-II cells (Figure 2C).
Localization (measured) of GFP-cav-1 in HPAF-II
5) Confidence 0.72 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.31 Pain Relevance 0
A major development in understanding Cav-1 biology was the discovery that Cav-1 is secreted by mouse and human prostate cancer cell lines.93 Phosphorylation of serine 80 in the CSD converts Cav-1 from an integral membrane protein to a secreted protein product.103 Cav-1 is then incorporated into other membrane-derived microvesicles that are secreted by prostate cancer cells, including “prostasomes” and “oncosomes”.104,105 Importantly, secreted Cav-1 confers growth-promoting and anti-apoptotic properties to cell lines lacking endogenous Cav-1.93 This effect is mediated through uptake of Cav-1 by the Cav-1-negative prostate cancer epithelial cells.14 In a preclinical orthotopic mouse model of prostate cancer, Cav-1 antibody suppressed growth and metastases of a Cav-1 secreting, castrate-resistant cancer cell line.93 These data indicate that secreted Cav-1 is a biologically active autocrine-paracrine factor that contributes to malignant progression and further suggest that Cav-1 is a valid therapy target.
Localization (secreted) of Cav-1 in epithelial cells associated with malignant neoplastic disease, cancer, prostate cancer, apoptosis and metastasis
6) Confidence 0.66 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 1.09 Pain Relevance 0
Because it is a secreted protein that can be reliably measured in peripheral blood by ELISA, Cav-1 has enormous potential as a novel biomarker in prostate cancer.
Localization (secreted) of Cav-1 in blood associated with prostate cancer
7) Confidence 0.66 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 1.09 Pain Relevance 0
A major development in understanding Cav-1 biology was the discovery that Cav-1 is secreted by mouse and human prostate cancer cell lines.93 Phosphorylation of serine 80 in the CSD converts Cav-1 from an integral membrane protein to a secreted protein product.103 Cav-1 is then incorporated into other membrane-derived microvesicles that are secreted by prostate cancer cells, including “prostasomes” and “oncosomes”.104,105 Importantly, secreted Cav-1 confers growth-promoting and anti-apoptotic properties to cell lines lacking endogenous Cav-1.93 This effect is mediated through uptake of Cav-1 by the Cav-1-negative prostate cancer epithelial cells.14 In a preclinical orthotopic mouse model of prostate cancer, Cav-1 antibody suppressed growth and metastases of a Cav-1 secreting, castrate-resistant cancer cell line.93 These data indicate that secreted Cav-1 is a biologically active autocrine-paracrine factor that contributes to malignant progression and further suggest that Cav-1 is a valid therapy target.
Localization (secreted) of Cav-1 in epithelial cells associated with malignant neoplastic disease, cancer, prostate cancer, apoptosis and metastasis
8) Confidence 0.66 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 1.05 Pain Relevance 0
A major development in understanding Cav-1 biology was the discovery that Cav-1 is secreted by mouse and human prostate cancer cell lines.93 Phosphorylation of serine 80 in the CSD converts Cav-1 from an integral membrane protein to a secreted protein product.103 Cav-1 is then incorporated into other membrane-derived microvesicles that are secreted by prostate cancer cells, including “prostasomes” and “oncosomes”.104,105 Importantly, secreted Cav-1 confers growth-promoting and anti-apoptotic properties to cell lines lacking endogenous Cav-1.93 This effect is mediated through uptake of Cav-1 by the Cav-1-negative prostate cancer epithelial cells.14 In a preclinical orthotopic mouse model of prostate cancer, Cav-1 antibody suppressed growth and metastases of a Cav-1 secreting, castrate-resistant cancer cell line.93 These data indicate that secreted Cav-1 is a biologically active autocrine-paracrine factor that contributes to malignant progression and further suggest that Cav-1 is a valid therapy target.
Localization (secreted) of Cav-1 in epithelial cells associated with malignant neoplastic disease, cancer, prostate cancer, apoptosis and metastasis
9) Confidence 0.66 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 1.27 Pain Relevance 0
In addition to its effects on prostate cancer epithelial cells, secreted Cav-1 also modulates the microenvironment in a manner that promotes tumor growth through neoangiogenesis.
Localization (secreted) of Cav-1 in epithelial cells associated with cancer and prostate cancer
10) Confidence 0.66 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 1.19 Pain Relevance 0
A major development in understanding Cav-1 biology was the discovery that Cav-1 is secreted by mouse and human prostate cancer cell lines.93 Phosphorylation of serine 80 in the CSD converts Cav-1 from an integral membrane protein to a secreted protein product.103 Cav-1 is then incorporated into other membrane-derived microvesicles that are secreted by prostate cancer cells, including “prostasomes” and “oncosomes”.104,105 Importantly, secreted Cav-1 confers growth-promoting and anti-apoptotic properties to cell lines lacking endogenous Cav-1.93 This effect is mediated through uptake of Cav-1 by the Cav-1-negative prostate cancer epithelial cells.14 In a preclinical orthotopic mouse model of prostate cancer, Cav-1 antibody suppressed growth and metastases of a Cav-1 secreting, castrate-resistant cancer cell line.93 These data indicate that secreted Cav-1 is a biologically active autocrine-paracrine factor that contributes to malignant progression and further suggest that Cav-1 is a valid therapy target.
Localization (secreted) of Cav-1 in epithelial cells associated with malignant neoplastic disease, cancer, prostate cancer, apoptosis and metastasis
11) Confidence 0.66 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 1.01 Pain Relevance 0
A major development in understanding Cav-1 biology was the discovery that Cav-1 is secreted by mouse and human prostate cancer cell lines.93 Phosphorylation of serine 80 in the CSD converts Cav-1 from an integral membrane protein to a secreted protein product.103 Cav-1 is then incorporated into other membrane-derived microvesicles that are secreted by prostate cancer cells, including “prostasomes” and “oncosomes”.104,105 Importantly, secreted Cav-1 confers growth-promoting and anti-apoptotic properties to cell lines lacking endogenous Cav-1.93 This effect is mediated through uptake of Cav-1 by the Cav-1-negative prostate cancer epithelial cells.14 In a preclinical orthotopic mouse model of prostate cancer, Cav-1 antibody suppressed growth and metastases of a Cav-1 secreting, castrate-resistant cancer cell line.93 These data indicate that secreted Cav-1 is a biologically active autocrine-paracrine factor that contributes to malignant progression and further suggest that Cav-1 is a valid therapy target.
Localization (secreting) of Cav-1 in epithelial cells associated with malignant neoplastic disease, cancer, prostate cancer, apoptosis and metastasis
12) Confidence 0.66 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 1.21 Pain Relevance 0
Moreover, patch-clamp studies revealed that PKC-epsilon-mediated inhibition of the K(ATP) current induced by PMA or angiotensin II was reduced by a dynamin mutant, as well as small interfering RNA targeting caveolin-1.
Localization (targeting) of caveolin-1 associated with kinase c
13) Confidence 0.44 Published 2008 Journal Hypertension Section Abstract Doc Link 18663158 Disease Relevance 0.15 Pain Relevance 0.41
Caveolin-1 and -2 co-localize and form a hetero-oligomeric complex in vivo [38].
Localization (localize) of Caveolin-1
14) Confidence 0.30 Published 2010 Journal PLoS ONE Section Body Doc Link PMC3012157 Disease Relevance 0.86 Pain Relevance 0.27
We therefore used anti-channel and anti-caveolin antibodies in immunocytochemical analysis to determine whether, in Ltk- cells expressing the WT and mutant channels, the channel proteins and caveolin localize to the same area of the membrane.
Localization (localize) of caveolin
15) Confidence 0.05 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2785819 Disease Relevance 0 Pain Relevance 0

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