INT153668

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Context Info
Confidence 0.41
First Reported 2001
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 5
Disease Relevance 2.23
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BTK) cytosol (BTK) plasma membrane (BTK)
nucleus (BTK) cytoplasm (BTK)
Anatomy Link Frequency
monocytes 4
BTK (Homo sapiens)
BTK - K44E (1)
Pain Link Frequency Relevance Heat
Kinase C 9 98.34 Very High Very High Very High
adenocard 1 75.00 Quite High
Angina 5 65.52 Quite High
Disease Link Frequency Relevance Heat
Disease 4 99.88 Very High Very High Very High
Agammaglobulinemia 184 96.36 Very High Very High Very High
Cytomegalovirus Infection 4 84.96 Quite High
Togavirus Infection 4 84.08 Quite High
Measles 4 83.52 Quite High
Immunodeficiency 20 79.96 Quite High
Acquired Immune Deficiency Syndrome Or Hiv Infection 4 72.24 Quite High
Liver Failure 4 66.76 Quite High
Bacterial Infection 8 65.96 Quite High
Cv General 3 Under Development 1 65.52 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Flow cytometric analysis of BTK expression in peripheral monocytes
Negative_regulation (analysis) of Gene_expression (expression) of BTK in monocytes
1) Confidence 0.41 Published 2001 Journal Respir Res Section Body Doc Link PMC2092384 Disease Relevance 0.71 Pain Relevance 0
Flow cytometric analysis of BTK expression in peripheral monocytes
Negative_regulation (analysis) of Gene_expression (expression) of BTK in monocytes
2) Confidence 0.41 Published 2001 Journal Respir Res Section Body Doc Link PMC2092384 Disease Relevance 0.62 Pain Relevance 0
Detection of a two base pair deletion in the BTK cDNA
Negative_regulation (deletion) of Gene_expression (Detection) of BTK cDNA
3) Confidence 0.41 Published 2001 Journal Respir Res Section Body Doc Link PMC2092384 Disease Relevance 0.48 Pain Relevance 0
Detection of a two base pair deletion in the BTK cDNA
Negative_regulation (deletion) of Gene_expression (Detection) of BTK cDNA
4) Confidence 0.41 Published 2001 Journal Respir Res Section Body Doc Link PMC2092384 Disease Relevance 0.24 Pain Relevance 0
Importantly, we demonstr</span>ated that activation of PKC-epsilon caused internalization of K(ATP) channels, the effect that was blocked by depletion</span> of cholesterol with methyl-beta-cyclodextrin, expression of dominant-negative dynamin mutant K44E, or knockdown of caveolin-1 with small interfering RNA.
Negative_regulation (depletion) of Gene_expression (expression) of dominant-negative dynamin mutant K44E (K44E) associated with kinase c
5) Confidence 0.08 Published 2008 Journal Hypertension Section Abstract Doc Link 18663158 Disease Relevance 0.20 Pain Relevance 0.46

General Comments

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