INT153670

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Context Info
Confidence 0.69
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 26
Total Number 48
Disease Relevance 44.27
Pain Relevance 0.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (CAV1) mitochondrion (CAV1) small molecule metabolic process (CAV1)
Golgi apparatus (CAV1) endoplasmic reticulum (CAV1) intracellular (CAV1)
Anatomy Link Frequency
margins 8
HPAF-II 6
fibroblasts 4
lymph node 2
plasma 2
CAV1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Kinase C 9 99.24 Very High Very High Very High
fibrosis 16 92.76 High High
Inflammation 54 91.04 High High
adenocard 1 75.00 Quite High
Angina 1 74.72 Quite High
metalloproteinase 42 73.20 Quite High
cytokine 35 61.52 Quite High
Osteoarthritis 7 55.12 Quite High
Chronic pancreatitis 32 22.40 Low Low
backache 56 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 2534 100.00 Very High Very High Very High
Aging 434 100.00 Very High Very High Very High
Repression 23 100.00 Very High Very High Very High
Stress 106 99.98 Very High Very High Very High
Targeted Disruption 69 99.98 Very High Very High Very High
Carcinoma 16 99.96 Very High Very High Very High
Prostate Cancer 2277 99.88 Very High Very High Very High
Sarcoma 46 99.88 Very High Very High Very High
Adenocarcinoma 823 99.68 Very High Very High Very High
Colon Cancer 46 99.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Here, we show that caveolin-1 gene expression and protein expression are increased during IVD degeneration, but not in a manner that is associated with increasing chronological age.
Positive_regulation (increased) of Gene_expression (expression) of caveolin-1 gene
1) Confidence 0.69 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 0.92 Pain Relevance 0.06
In mouse NIH 3T3 fibroblasts, administration of subcytotoxic levels of H2O2 to experimentally mimic oxidative stress induced cellular senescence and increased caveolin-1 expression.
Positive_regulation (induced) of Gene_expression (expression) of caveolin-1 in fibroblasts associated with stress and aging
2) Confidence 0.69 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 1.23 Pain Relevance 0
Both in renal cell and oral carcinomas, cav-1 is overexpressed in primary tumors but low or absent in distant metastases.
Positive_regulation (overexpressed) of Neg (absent) Gene_expression (overexpressed) of cav-1 associated with cancer, carcinoma and metastasis
3) Confidence 0.67 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.72 Pain Relevance 0
Using a variation of the colloidal gold assay, we compared untransfected, GFP-vector control and GFP-cav-1 transfected HPAF-II cells in a blue fluorescent bead random migration assay.
Positive_regulation (transfected) of Gene_expression (transfected) of GFP-cav-1 in HPAF-II
4) Confidence 0.67 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.17 Pain Relevance 0
Loss and overexpression of cav-1 has also been associated with the progression to a metastatic phenotype within different cancers [47,8].
Positive_regulation (overexpression) of Gene_expression (overexpression) of cav-1 associated with cancer
5) Confidence 0.67 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.78 Pain Relevance 0
Recent immunohistochemical studies have implicated increased cav-1 expression as a poor prognostic factor for pancreatic adenocarcinoma (PC) [13].
Positive_regulation (increased) of Gene_expression (expression) of cav-1 associated with adenocarcinoma
6) Confidence 0.67 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.41 Pain Relevance 0
Both loss and overexpression cav-1 has been described in tumor progression, sometimes within the same tumor type [44-47].
Positive_regulation (overexpression) of Gene_expression (overexpression) of cav-1 associated with cancer
7) Confidence 0.67 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.62 Pain Relevance 0
Increased Cav-1 expression also correlates with hormone ablative therapy.93 Analysis of primary tumor and metastatic specimens from patients with metastatic disease demonstrated that aberrant expression of Cav-1 was increased after hormone ablation in both primary (73% versus 38%) and metastatic (82% versus 62%) sites.
Positive_regulation (Increased) of Gene_expression (expression) of Cav-1 associated with cancer and metastasis
8) Confidence 0.65 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 1.35 Pain Relevance 0
The mechanism(s) for increased expression of Cav-1 in aggressive prostate cancer remains unclear.
Positive_regulation (increased) of Gene_expression (expression) of Cav-1 associated with prostate cancer
9) Confidence 0.65 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 1.13 Pain Relevance 0
Cav-1 is located on 7q31.1, a conserved fragile site that is frequently deleted and/or amplified in human cancers.94,95 In addition, the gene promoter for Cav-1 possesses a “CpG” island that has been reported to be hypermethylated, an event generally associated with transcriptional repression.96 However, Cav-1 expression levels do not consistently correlate with genetic and/or methylation changes of the Cav-1 gene.97 More recently, an alternative epigenetic mechanism for increased Cav-1 expression has been proposed through the aberrant, cancer-specific loss of miR-205, a noncoding microRNA that normally silences Cav-1 expression.98
Positive_regulation (increased) of Gene_expression (expression) of Cav-1 associated with cancer and repression
10) Confidence 0.65 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 0.82 Pain Relevance 0
In another study, patients with increased Cav-1 expression were at increased risk for developing an aggressive recurrence after surgery as defined by a PSADT of <10 months, failure to respond to salvage radiotherapy, and/or radiographically detected metastases.89 Taken together, these studies suggest that Cav-1 expression predicts development of prostate cancer with lethal potential.
Positive_regulation (increased) of Gene_expression (expression) of Cav-1 associated with prostate cancer, metastasis and recurrence
11) Confidence 0.65 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 1.23 Pain Relevance 0
The focal expression of Cav-1 in primary prostate cancers, the increase in Cav-1 expression in untreated metastases, and the additional increase in Cav-1 expression in tumors treated with hormone ablative therapy support the hypothesis that Cav-1 functions in progression-related events rather than local tumor growth.
Positive_regulation (increase) of Gene_expression (expression) of Cav-1 associated with cancer, prostate cancer and metastasis
12) Confidence 0.65 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 1.20 Pain Relevance 0
Cav-1 expression proportionally increases in high-grade primary tumors with lymph node metastases (T3N1; ?
Positive_regulation (increases) of Gene_expression (expression) of Cav-1 in lymph node associated with cancer and metastasis
13) Confidence 0.65 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 1.30 Pain Relevance 0
In contrast, immunohistochemistry analyses of primary human tumors of bladder, esophageal, breast, and prostate origin demonstrated aberrant overexpression of Cav-1 relative to normal tissues, suggesting an oncogenic role for Cav-1 for select tumor types.85–88 Importantly, immunohistochemical analysis of radical prostatectomy specimens obtained from patients with clinically localized tumors demonstrated that Cav-1 expression is positively associated with increasing Gleason grade, increasing Gleason score, lymph node involvement, and positive surgical margins.88 In a subset of lymph node-negative patients, multivariate analysis indicated that positive Cav-1 expression is an independent prognostic factor for a higher Gleason score (>7), extraprostatic extension, seminal vesicle involvement, positive surgical margins, and shorter time to disease progression.
Positive_regulation (overexpression) of Gene_expression (overexpression) of Cav-1 in margins associated with cancer and disease progression
14) Confidence 0.65 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 1.43 Pain Relevance 0
Increased Cav-1 expression also correlates with hormone ablative therapy.93 Analysis of primary tumor and metastatic specimens from patients with metastatic disease demonstrated that aberrant expression of Cav-1 was increased after hormone ablation in both primary (73% versus 38%) and metastatic (82% versus 62%) sites.
Positive_regulation (increased) of Gene_expression (expression) of Cav-1 associated with cancer and metastasis
15) Confidence 0.65 Published 2010 Journal Cancer management and research Section Body Doc Link PMC3004586 Disease Relevance 1.25 Pain Relevance 0
Cav-1 is aberrantly overexpressed in human prostate cancer, with higher levels evident in metastatic versus primary sites.
Positive_regulation (overexpressed) of Gene_expression (overexpressed) of Cav-1 associated with prostate cancer
16) Confidence 0.65 Published 2010 Journal Cancer management and research Section Abstract Doc Link PMC3004586 Disease Relevance 0.87 Pain Relevance 0
The present study demonstrated that the increased expression of caveolin-1 seen in the degenerate NP positively correlated with gene expression for p16INK4a, suggesting that caveolin-1 expression is linked to the senescent phenotype observed in these cells.
Positive_regulation (increased) of Gene_expression (expression) of caveolin-1
17) Confidence 0.50 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 0.87 Pain Relevance 0
Treatment with H2O2 in the presence of caveolin-1 antisense oligonucleotides reduced expression of senescence biomarkers, whereas transgenic overexpression of caveolin-1 induced SIPS [31].
Positive_regulation (overexpression) of Gene_expression (overexpression) of caveolin-1 associated with targeted disruption and aging
18) Confidence 0.50 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2575636 Disease Relevance 1.38 Pain Relevance 0
These results suggest that high cav-1 expression may be associated with primary tumors, while loss of cav-1 may be associated with metastases.
Positive_regulation (high) of Gene_expression (expression) of cav-1 associated with cancer and metastasis
19) Confidence 0.48 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 1.26 Pain Relevance 0.05
High cav-1 protein expression leads to inhibition of RhoC activation while inhibition of RhoC activity leads to partial re-expression of cav-1.
Positive_regulation (High) of Gene_expression (expression) of cav-1 protein
20) Confidence 0.48 Published 2005 Journal Mol Cancer Section Body Doc Link PMC1173138 Disease Relevance 0.13 Pain Relevance 0

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