INT153674

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Context Info
Confidence 0.75
First Reported 2001
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 14
Total Number 14
Disease Relevance 8.40
Pain Relevance 0.49

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lipid binding (BTK) cytosol (BTK) plasma membrane (BTK)
nucleus (BTK) cytoplasm (BTK)
Anatomy Link Frequency
monocytes 5
B cells 2
hematopoietic cells 1
BTK (Homo sapiens)
BTK - K44E (1)
Pain Link Frequency Relevance Heat
Kinase C 9 97.22 Very High Very High Very High
alcohol 1 85.04 High High
adenocard 1 75.00 Quite High
Angina 12 63.28 Quite High
headache 5 5.00 Very Low Very Low Very Low
cINOD 2 5.00 Very Low Very Low Very Low
Pain 2 5.00 Very Low Very Low Very Low
addiction 2 5.00 Very Low Very Low Very Low
Antihistamine 1 5.00 Very Low Very Low Very Low
Bioavailability 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 29 99.88 Very High Very High Very High
Agammaglobulinemia 516 99.14 Very High Very High Very High
Syndrome 1 97.56 Very High Very High Very High
Cytomegalovirus Infection 11 84.48 Quite High
Togavirus Infection 11 83.60 Quite High
Measles 11 83.04 Quite High
Immunodeficiency 59 79.48 Quite High
Breast Cancer 28 79.28 Quite High
Bacterial Infection 33 76.80 Quite High
Infection 81 76.28 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Monocytes with deleted BTK are not representative of all that is happening in the B cells, despite the fact that the detection of the BTK production in monocytes by flow cytometry is a powerful diagnostic tool for screening XLA patients.
Gene_expression (production) of BTK in B cells associated with agammaglobulinemia
1) Confidence 0.75 Published 2001 Journal Respir Res Section Body Doc Link PMC2092384 Disease Relevance 0.95 Pain Relevance 0
This deletion places a stop codon just downstream, thus producing a truncated BTK protein with 604 amino acid residues instead of the normal BTK protein with 659 residues (Fig. 1C,D).
Gene_expression (producing) of BTK
2) Confidence 0.75 Published 2001 Journal Respir Res Section Body Doc Link PMC2092384 Disease Relevance 0.53 Pain Relevance 0
Flow cytometric analysis of BTK expression in peripheral monocytes
Gene_expression (expression) of BTK in monocytes
3) Confidence 0.75 Published 2001 Journal Respir Res Section Body Doc Link PMC2092384 Disease Relevance 0.61 Pain Relevance 0
The patient showed a partial BTK deficiency, and his mother showed a two-peak BTK expression profile.
Gene_expression (expression) of BTK
4) Confidence 0.75 Published 2001 Journal Respir Res Section Body Doc Link PMC2092384 Disease Relevance 0.56 Pain Relevance 0
We then measured BTK protein in peripheral monocytes because they have been reported to express BTK (Fig. 1B).
Gene_expression (express) of BTK in monocytes
5) Confidence 0.75 Published 2001 Journal Respir Res Section Body Doc Link PMC2092384 Disease Relevance 0.58 Pain Relevance 0
Demonstration of a two-peak BTK expression pattern in peripheral monocytes is therefore diagnostic of the XLA carrier state in females [5].
Gene_expression (expression) of BTK in monocytes associated with agammaglobulinemia
6) Confidence 0.75 Published 2001 Journal Respir Res Section Body Doc Link PMC2092384 Disease Relevance 0.60 Pain Relevance 0
Non-B hematopoietic cells in XLA carriers, on the contrary, undergo random inactivation of the normal and mutated X chromosomes, and thus the product of the BTK gene can be detected in B cells and other hematopoietic cells.
Gene_expression (detected) of BTK gene in hematopoietic cells associated with agammaglobulinemia
7) Confidence 0.75 Published 2001 Journal Respir Res Section Body Doc Link PMC2092384 Disease Relevance 1.00 Pain Relevance 0
Flow cytometric analysis of BTK expression in peripheral monocytes
Gene_expression (expression) of BTK in monocytes
8) Confidence 0.75 Published 2001 Journal Respir Res Section Body Doc Link PMC2092384 Disease Relevance 0.70 Pain Relevance 0
Detection of a two base pair deletion in the BTK cDNA
Gene_expression (Detection) of BTK cDNA
9) Confidence 0.65 Published 2001 Journal Respir Res Section Body Doc Link PMC2092384 Disease Relevance 0.24 Pain Relevance 0
Detection of a two base pair deletion in the BTK cDNA
Gene_expression (Detection) of BTK cDNA
10) Confidence 0.65 Published 2001 Journal Respir Res Section Body Doc Link PMC2092384 Disease Relevance 0.48 Pain Relevance 0
We found that, for the flow cytometric analysis, it is key to measure BTK expression in peripheral monocytes.
Gene_expression (expression) of BTK in monocytes
11) Confidence 0.58 Published 2001 Journal Respir Res Section Body Doc Link PMC2092384 Disease Relevance 0.92 Pain Relevance 0
The syndrome described by Bruton would come to be known as X-linked agammaglobulinemia (XLA), a defect in the development of antibody producing B lymphocytes of boys with a mutation in the Bruton tyrosine kinase (BTK) gene.
Gene_expression (producing) of BTK in B lymphocytes associated with syndrome and agammaglobulinemia
12) Confidence 0.45 Published 2010 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2817783 Disease Relevance 0.89 Pain Relevance 0.04
Importantly, we demonstr</span>ated that activation of PKC-epsilon caused internalization of K(ATP) channels, the effect that was blocked by depletion of cholesterol with methyl-beta-cyclodextrin, expression of dominant-negative dynamin mutant K44E, or knockdown of caveolin-1 with small interfering RNA.
Gene_expression (expression) of dominant-negative dynamin mutant K44E (K44E) associated with kinase c
13) Confidence 0.15 Published 2008 Journal Hypertension Section Abstract Doc Link 18663158 Disease Relevance 0.19 Pain Relevance 0.45
-catenin suppression or expression of a dominant-negative TCF (Fig. 5A).
Gene_expression (expression) of dominant-negative TCF
14) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2813871 Disease Relevance 0.15 Pain Relevance 0

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