INT153684

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Context Info
Confidence 0.31
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 4
Disease Relevance 1.19
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Bcl2l11) mitochondrion (Bcl2l11) cytoplasm (Bcl2l11)
Bcl2l11 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Kinase C 48 100.00 Very High Very High Very High
adenocard 7 98.32 Very High Very High Very High
Morphine 6 97.64 Very High Very High Very High
dorsal root ganglion 62 92.16 High High
Pain 9 88.12 High High
Opioid 1 82.00 Quite High
Pain management 1 80.92 Quite High
qutenza 74 79.80 Quite High
imagery 12 78.84 Quite High
Analgesic 4 76.84 Quite High
Disease Link Frequency Relevance Heat
Hyperalgesia 10 99.40 Very High Very High Very High
Ganglion Cysts 73 92.16 High High
Pain 11 88.12 High High
Injury 2 68.44 Quite High
Pressure And Volume Under Development 1 64.68 Quite High
INFLAMMATION 5 62.76 Quite High
Nociception 41 50.00 Quite Low
Neuropathic Pain 4 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Reprotox - General 1 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The novel inhibitor of the heterotrimeric G-protein complex, BIM-46187, elicits anti-hyperalgesic properties and synergizes with morphine.
Negative_regulation (inhibitor) of BIM-46187 associated with hyperalgesia and morphine
1) Confidence 0.31 Published 2008 Journal Eur. J. Pharmacol. Section Title Doc Link 18664366 Disease Relevance 0.76 Pain Relevance 0.93
Staurosporine inhibits a number of protein kinases including PKC, CaMKII, and tyrosine kinase (p60v-src), but BIM is a highly selective PKC inhibitor.
Negative_regulation (inhibitor) of BIM associated with kinase c
2) Confidence 0.08 Published 2010 Journal Mol Pain Section Body Doc Link PMC2936373 Disease Relevance 0.36 Pain Relevance 0.51
M BIM (bisindolylmaleimide), a specific PKC inhibitor, 25 ?
Negative_regulation (inhibitor) of BIM associated with kinase c
3) Confidence 0.05 Published 2010 Journal Mol Pain Section Body Doc Link PMC2936373 Disease Relevance 0 Pain Relevance 0.36
Evidence for this is that ET-1 effects were completely inhibited by the PKC inhibitor BIM X, and prevented in the PKC phosphorylation site mutant TRPV1-S800A.
Negative_regulation (inhibitor) of BIM
4) Confidence 0.05 Published 2007 Journal Mol Pain Section Body Doc Link PMC2206006 Disease Relevance 0.07 Pain Relevance 0.10

General Comments

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