INT15370

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Context Info
Confidence 0.29
First Reported 1989
Last Reported 2010
Negated 1
Speculated 3
Reported most in Abstract
Documents 24
Total Number 27
Disease Relevance 5.84
Pain Relevance 18.16

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (Nkx1-1) neurological system process (Nkx1-1)
Anatomy Link Frequency
neurons 2
dorsal horn 2
spinal 1
nerve 1
brainstem 1
Nkx1-1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
substance P 583 100.00 Very High Very High Very High
antagonist 51 100.00 Very High Very High Very High
Glutamate 25 100.00 Very High Very High Very High
opioid receptor 4 99.86 Very High Very High Very High
Kinase C 77 99.84 Very High Very High Very High
nav1.8 130 99.80 Very High Very High Very High
Pain 103 99.66 Very High Very High Very High
nociceptor 15 99.66 Very High Very High Very High
Antinociceptive 1 99.36 Very High Very High Very High
Dorsal horn 16 99.20 Very High Very High Very High
Disease Link Frequency Relevance Heat
Nociception 78 99.66 Very High Very High Very High
Neurogenic Inflammation 8 98.44 Very High Very High Very High
INFLAMMATION 162 97.28 Very High Very High Very High
Ganglion Cysts 200 97.10 Very High Very High Very High
Headache 1 96.60 Very High Very High Very High
Vomiting 6 96.04 Very High Very High Very High
Hypersensitivity 9 94.96 High High
Sleep Disorders 1 92.24 High High
Ataxia 1 91.44 High High
Pain 97 90.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Specific BHSP binding was inhibited by substance P greater than neurokinin A greater than neurokinin B, indicating binding to an NK1 (substance P-preferring) site.
NK1 Binding (binding) of associated with substance p
1) Confidence 0.29 Published 1989 Journal Neurosci. Lett. Section Abstract Doc Link 2479891 Disease Relevance 0.09 Pain Relevance 0.43
The association between NPY-containing axons and NK1 receptor-immunoreactive neurons was specific, because postsynaptic dorsal column neurons (which were located in laminae III-V but did not possess NK1 receptors) and lamina I neurons with the NK1 receptor received significantly fewer contacts from NPY-immunoreactive axons.
NK1 Binding (association) of in neurons associated with dorsal column
2) Confidence 0.27 Published 1999 Journal J. Neurosci. Section Abstract Doc Link 10087077 Disease Relevance 0.08 Pain Relevance 0.63
We examined potential functional sites for interactions between SP and MOR with dual electron microscopic immmunocytochemical localization of the SP receptor (NK1) and MOR in rat trigeminal dorsal horn.
NK1 Spec (examined) Binding (interactions) of in dorsal horn associated with dorsal horn and substance p
3) Confidence 0.16 Published 2000 Journal J. Neurosci. Section Abstract Doc Link 10818170 Disease Relevance 0 Pain Relevance 1.13
mu-Opioid receptors often colocalize with the substance P receptor (NK1) in the trigeminal dorsal horn.
NK1 Binding (colocalize) of in dorsal horn associated with dorsal horn, opioid receptor and substance p
4) Confidence 0.16 Published 2000 Journal J. Neurosci. Section Title Doc Link 10818170 Disease Relevance 0 Pain Relevance 1.12
While much more potent GABA(B) receptor agonists (CGP 44532) have been developed, there is no information on their antinociceptive properties or their ability to influence NK-1 receptors.
NK-1 Binding (influence) of associated with gaba, agonist and antinociceptive
5) Confidence 0.15 Published 1998 Journal Life Sci. Section Abstract Doc Link 9585130 Disease Relevance 0.45 Pain Relevance 0.91
Additional contractile and radioligand binding studies with receptor selective agonists and antagonists confirmed the presence of NK3 receptors and also revealed the presence of NK1 and NK2 receptors.
NK1 Binding (presence) of associated with antagonist and agonist
6) Confidence 0.10 Published 1991 Journal Eur. J. Pharmacol. Section Abstract Doc Link 1724757 Disease Relevance 0 Pain Relevance 0.32
Pretreatment with CGRP 8-37 (CGRP receptor antagonist) and NK-1 but not NK-2 nor NK-3 receptor antagonists significantly reduced the HABF by 43% (p< 0.05) and 25% (p< 0.05) as compared to the HABF value in the control HABR group.
NK-1 Binding (Pretreatment) of associated with antagonist
7) Confidence 0.10 Published 2005 Journal J. Physiol. Pharmacol. Section Abstract Doc Link 15795481 Disease Relevance 0.13 Pain Relevance 0.42
In agreement with our previous finding that the modulation of TRPV1 by NK-1 receptor was mediated by activation of PLC and downstream PKC pathway [9], the present results also proved the involvement of PKC in the interaction between NK-1 and Nav1.8.
NK-1 Binding (interaction) of associated with kinase c and nav1.8
8) Confidence 0.09 Published 2009 Journal Mol Pain Section Body Doc Link PMC2715383 Disease Relevance 0.21 Pain Relevance 1.46
M) still fully enhanced Nav1.8 currents in 9 of 24 DRG neurons (Figure 3C and 3D, control = 99.2 ± 0.5%, Sar-SP = 115.6 ± 2.1%, p < 0.001), suggesting that the PKA pathway did not participate in the interaction of NK-1 and Nav1.8.
NK-1 Binding (interaction) of in neurons associated with dorsal root ganglion, nav1.8 and substance p
9) Confidence 0.09 Published 2009 Journal Mol Pain Section Body Doc Link PMC2715383 Disease Relevance 0.17 Pain Relevance 1.60
Application of substance P, neurokinin A or neurokinin B induced dose-dependent internalization of NK1 and NK3 receptor.
NK1 Binding (internalization) of associated with substance p
10) Confidence 0.08 Published 2002 Journal Neuroscience Section Abstract Doc Link 12453476 Disease Relevance 0 Pain Relevance 0.38
These results demonstrate that internalization and recycling mechanisms of NK1 or NK3 receptor were preserved in in vitro brainstem slices.
NK1 Binding (internalization) of in brainstem associated with medulla
11) Confidence 0.08 Published 2002 Journal Neuroscience Section Abstract Doc Link 12453476 Disease Relevance 0 Pain Relevance 0.39
We used internalization of the NK1 or NK3 receptor as an index of endogenous neurokinin release assessed by immunocytochemical visualization of the NK1 or NK3 receptor endocytosis.
NK1 Binding (visualization) of
12) Confidence 0.08 Published 2002 Journal Neuroscience Section Abstract Doc Link 12453476 Disease Relevance 0 Pain Relevance 0.36
The NK1 receptor antagonist SR140333 blocked internalization of NK1 receptor induced by the three neurokinins.
NK1 Binding (internalization) of associated with antagonist
13) Confidence 0.08 Published 2002 Journal Neuroscience Section Abstract Doc Link 12453476 Disease Relevance 0 Pain Relevance 0.40
We used internalization of the NK1 or NK3 receptor as an index of endogenous neurokinin release assessed by immunocytochemical visualization of the NK1 or NK3 receptor endocytosis.
NK1 Binding (internalization) of
14) Confidence 0.08 Published 2002 Journal Neuroscience Section Abstract Doc Link 12453476 Disease Relevance 0 Pain Relevance 0.36
Evidence for the interaction of glutamate and NK1 receptors in the periphery.
NK1 Binding (interaction) of associated with glutamate and nociceptor
15) Confidence 0.08 Published 1998 Journal Brain Res. Section Title Doc Link 9593874 Disease Relevance 0.34 Pain Relevance 1.32
The NK-1, NK-2 and NK-3 receptor ligands [Sar9, Met(O2)11]SP, R396 and senktide, respectively, showed no or negligible binding.
NK-1 Binding (binding) of associated with substance p
16) Confidence 0.08 Published 2006 Journal Peptides Section Abstract Doc Link 16216386 Disease Relevance 0.30 Pain Relevance 1.23
In vitro characterization of the non-peptide tachykinin NK1 and NK2-receptor antagonists, SR140333 and SR48968 in different rat and guinea-pig intestinal segments.
NK1 Binding (characterization) of associated with antagonist
17) Confidence 0.07 Published 1995 Journal Life Sci. Section Title Doc Link 7529864 Disease Relevance 0 Pain Relevance 0.48
This suggests that PD 156982 can effectively antagonize peripheral NK1 receptors in vivo.
NK1 Binding (antagonize) of
18) Confidence 0.07 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9618426 Disease Relevance 0.54 Pain Relevance 0.33
These data suggest that the conjugate binds to NK1 and NK2 receptors with approximately the same affinity.
NK1 Binding (binds) of
19) Confidence 0.06 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1878491 Disease Relevance 0.24 Pain Relevance 0.23
Takeda and colleagues previously demonstrated that substance P had a ten fold higher affinity for NK1 than NK2 receptors [25].
NK1 Binding (affinity) of associated with substance p
20) Confidence 0.06 Published 2007 Journal BMC Neurosci Section Body Doc Link PMC1878491 Disease Relevance 0.22 Pain Relevance 0.24

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