INT153701

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Context Info
Confidence 0.37
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.66
Pain Relevance 0.86

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (CLDN7) plasma membrane (CLDN7)
CLDN7 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 9 99.70 Very High Very High Very High
Crohn's disease 22 97.92 Very High Very High Very High
abdominal pain 1 83.56 Quite High
Inflammation 5 79.64 Quite High
Inflammatory response 1 74.48 Quite High
cINOD 1 62.88 Quite High
spastic colon 23 5.00 Very Low Very Low Very Low
adenocard 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
spinal inflammation 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Disease 33 97.92 Very High Very High Very High
Inflammatory Bowel Disease 22 92.56 High High
Abdominal Pain 1 83.56 Quite High
Diarrhoea 4 82.80 Quite High
INFLAMMATION 6 79.64 Quite High
Injury 1 64.08 Quite High
Enteropathy 6 51.20 Quite High
Sprains And Strains 25 5.00 Very Low Very Low Very Low
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super

22 5.00 Very Low Very Low Very Low
Bacterial Respiratory Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aspirin significantly decreased the quantity of claudin-7 protein produced by MKN28 cells but not the quantity of claudin-3, claudin-4, ZO-1, or occludin.
Negative_regulation (decreased) of Gene_expression (produced) of claudin-7 protein associated with aspirin
1) Confidence 0.37 Published 2008 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 18667601 Disease Relevance 0.13 Pain Relevance 0.39
mucosal biopsy samples revealed a significantly higher prevalence of Clostridium spp., Ruminococcus torques, and E. coli in samples from CD
Negative_regulation (prevalence) of Gene_expression (spp.) of Clostridium associated with crohn's disease
2) Confidence 0.02 Published 2008 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2648627 Disease Relevance 1.54 Pain Relevance 0.47

General Comments

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