INT153702

Context Info Confidence 0.29 First Reported 2008 Last Reported 2010 Negated 0 Speculated 1 Reported most in Body Documents 4 Total Number 5 Disease Relevance 0.97 Pain Relevance 0.41

structural molecule activity (CLDN7) plasma membrane (CLDN7)

CLDN7 (Homo sapiens)

Pain Link Frequency Relevance Heat aspirin 9 98.98 cINOD 1 96.68 Crohn's disease 9 5.00 Inflammation 9 5.00 tramadol 6 5.00 Earache 4 5.00 Analgesic 3 5.00 Osteoarthritis 3 5.00

Disease Link Frequency Relevance Heat Diarrhoea 242 98.80 INFLAMMATION 4 95.96 Injury 1 94.28 Disease 40 5.00 Sprains And Strains 25 5.00 Giardiasis 24 5.00 Inflammatory Bowel Disease 15 5.00 Vomiting 6 5.00 Food Poisoning 6 5.00 Earache 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Aspirin induces gastric epithelial barrier dysfunction by activating p38 MAPK via claudin-7.

Positive_regulation (activating) of claudin-7 associated with aspirin

1) Confidence 0.29 Published 2008 Journal Am. J. Physiol., Cell Physiol. Section Title Doc Link 18667601 Disease Relevance 0.19 Pain Relevance 0.41

Frozen DNA extracts were sent from EMSL Analytical to the US EPA in Cincinnati where qPCR analysis was conducted for Clostridium.

Positive_regulation (conducted) of Clostridium

2) Confidence 0.05 Published 2010 Journal Environ Health Section Body Doc Link PMC2990738 Disease Relevance 0 Pain Relevance 0

analysis indicated an increase in Clostridium group I, of

Positive_regulation (increase) of Clostridium

3) Confidence 0.01 Published 2008 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2648299 Disease Relevance 0.33 Pain Relevance 0

long, we cannot determine whether the increases in Clostridium group I

Spec (whether) Positive_regulation (increases) of Clostridium

4) Confidence 0.01 Published 2008 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2648299 Disease Relevance 0.36 Pain Relevance 0

Substantial changes in the microbiota occurred during diarrheic episodes, including increased levels of Clostridium perfringens, Enterococcus faecalis, and Enterococcus faecium.

Positive_regulation (increased) of Clostridium

5) Confidence 0.01 Published 2008 Journal Interdisciplinary Perspectives on Infectious Diseases Section Abstract Doc Link PMC2648299 Disease Relevance 0.09 Pain Relevance 0

General Comments

This test has worked.