INT153705

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Context Info
Confidence 0.58
First Reported 2002
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 4.07
Pain Relevance 0.37

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (CLDN3) plasma membrane (CLDN3)
Anatomy Link Frequency
Plasma 1
epithelial cell 1
keratinocytes 1
bowel 1
CLDN3 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 9 97.48 Very High Very High Very High
Inflammatory response 13 86.24 High High
cINOD 1 85.64 High High
Inflammation 55 31.60 Quite Low
cytokine 16 5.00 Very Low Very Low Very Low
member 8 4 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
fibrosis 2 5.00 Very Low Very Low Very Low
ischemia 2 5.00 Very Low Very Low Very Low
abdominal pain 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 25 99.96 Very High Very High Very High
Infection 34 99.60 Very High Very High Very High
Abscess 6 99.12 Very High Very High Very High
Anaerobic Bacterial Infections 17 98.60 Very High Very High Very High
Leukemia 5 98.54 Very High Very High Very High
Malignant Neoplastic Disease 14 95.20 Very High Very High Very High
Congenital Anomalies 23 93.24 High High
Bacteremia 77 90.32 High High
Diabetes Mellitus 10 90.16 High High
Injury 18 86.84 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
EGF also induced their expression under these conditions (unpublished data), but it can obviously not compensate for the loss of FGF receptors because expression of claudin 1, claudin 3, and occludin was reduced in keratinocytes of K5-R1/R2 mice, which were cultured in the presence of EGF (Fig. 9 B).
Gene_expression (expression) of claudin 3 in keratinocytes
1) Confidence 0.58 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.06 Pain Relevance 0
Concomitantly, expression of IL-1F8 was reduced by 30%, whereas no obvious change in the expression of claudin 1, claudin 3, or occludin was observed (unpublished data).
Gene_expression (expression) of claudin 3
2) Confidence 0.58 Published 2010 Journal The Journal of Cell Biology Section Body Doc Link PMC2845079 Disease Relevance 0.17 Pain Relevance 0.04
We found 16 cases similar to our own, presenting with bowel pathology as a source of Clostridium septicum infection and metastatic myonecrosis [3,5,6,8,10,11,14-16].
Gene_expression (source) of Clostridium in bowel associated with anaerobic bacterial infections and infection
3) Confidence 0.35 Published 2008 Journal World J Emerg Surg Section Body Doc Link PMC2311281 Disease Relevance 1.57 Pain Relevance 0
Thus, we examined the effect of aspirin on gastric mucosal barrier properties and tight junction organization using MKN28, a human gastric epithelial cell line that expresses claudin-3, claudin-4, claudin-7, zonula occludens (ZO)-1, and occludin, but not claudin-2 or claudin-5, as determined by immunoblot analysis and immunofluorescent staining.
Spec (determined) Gene_expression (expresses) of claudin-3 in epithelial cell associated with aspirin
4) Confidence 0.35 Published 2008 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 18667601 Disease Relevance 0.17 Pain Relevance 0.33
Bacteroides fragilis group isolates were recovered in three instances (two in patients with leukemia who had a perirectal abscess), Staphylococcus aureus in three patients, Clostridium spp. in two (one C. perfringens and one C. septicum) and two Proteus spp.
Gene_expression (spp.) of Clostridium associated with leukemia and abscess
5) Confidence 0.35 Published 2002 Journal Crit Care Section Body Doc Link PMC137446 Disease Relevance 1.62 Pain Relevance 0
Plasma concentration of I-FABP, I-BABP and urinary expression of claudin-3 increased rapidly and significantly after the onset of surgery in most children.
Gene_expression (expression) of claudin-3 in Plasma
6) Confidence 0.20 Published 2008 Journal PLoS ONE Section Abstract Doc Link PMC2599890 Disease Relevance 0.22 Pain Relevance 0
The validity of the animal model was first checked using gnotobiotic rats monoassociated with a Clostridium butyricum hydrogen (H2)-producing strain.
Gene_expression (producing) of Clostridium associated with sprains and strains
7) Confidence 0.01 Published 2008 Journal BMC Microbiol Section Abstract Doc Link PMC2270848 Disease Relevance 0.26 Pain Relevance 0

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