INT153706

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Context Info
Confidence 0.49
First Reported 2008
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 5
Total Number 6
Disease Relevance 3.02
Pain Relevance 1.26

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

structural molecule activity (CLDN7) plasma membrane (CLDN7)
Anatomy Link Frequency
spore 1
epithelial cell 1
CLDN7 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 18 99.18 Very High Very High Very High
Crohn's disease 47 97.92 Very High Very High Very High
cINOD 2 85.64 High High
abdominal pain 2 83.00 Quite High
Inflammation 13 79.08 Quite High
Potency 2 75.52 Quite High
Inflammatory response 2 73.92 Quite High
spastic colon 46 5.00 Very Low Very Low Very Low
tramadol 2 5.00 Very Low Very Low Very Low
adenocard 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sprains And Strains 62 99.20 Very High Very High Very High
Disease 79 97.92 Very High Very High Very High
Giardiasis 8 92.88 High High
Diarrhoea 85 92.80 High High
Clostridium Difficile Infection 1 92.52 High High
Inflammatory Bowel Disease 49 92.00 High High
Cyclosporiasis 1 91.60 High High
Paralysis 1 91.12 High High
Poisoning 3 90.08 High High
Cryptosporidiosis 1 89.80 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Aspirin significantly decreased the quantity of claudin-7 protein produced by MKN28 cells but not the quantity of claudin-3, claudin-4, ZO-1, or occludin.
Gene_expression (produced) of claudin-7 protein associated with aspirin
1) Confidence 0.49 Published 2008 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 18667601 Disease Relevance 0.12 Pain Relevance 0.39
Thus, we examined the effect of aspirin on gastric mucosal barrier properties and tight junction organization using MKN28, a human gastric epithelial cell line that expresses claudin-3, claudin-4, claudin-7, zonula occludens (ZO)-1, and occludin, but not claudin-2 or claudin-5, as determined by immunoblot analysis and immunofluorescent staining.
Spec (determined) Gene_expression (expresses) of claudin-7 in epithelial cell associated with aspirin
2) Confidence 0.38 Published 2008 Journal Am. J. Physiol., Cell Physiol. Section Abstract Doc Link 18667601 Disease Relevance 0.17 Pain Relevance 0.33
mucosal biopsy samples revealed a significantly higher prevalence of Clostridium spp., Ruminococcus torques, and E. coli in samples from CD
Gene_expression (spp.) of Clostridium associated with crohn's disease
3) Confidence 0.03 Published 2008 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2648627 Disease Relevance 1.53 Pain Relevance 0.47
This approach indicated that E. coli and Clostridium spp. were the main groups among the initial colonizers, which were rapidly
Gene_expression (spp.) of Clostridium
4) Confidence 0.03 Published 2008 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2648627 Disease Relevance 0 Pain Relevance 0
coli, toxin-producing Clostridium perfringens, Staphylococcus
Gene_expression (producing) of Clostridium
5) Confidence 0.01 Published 2008 Journal Interdisciplinary Perspectives on Infectious Diseases Section Body Doc Link PMC2648299 Disease Relevance 0.78 Pain Relevance 0
Specific species of the spore forming anaerobe Clostridium produce BoNT as 150 kDa proteins with one or more neurotoxin accessory proteins (NAPs) to form toxin complexes or progenitors of varying sizes approximately 300, 500, and 900 kDa known as M, L and LL.
Gene_expression (produce) of Clostridium in spore
6) Confidence 0.01 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2809108 Disease Relevance 0.42 Pain Relevance 0.07

General Comments

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