INT153714

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 7
Disease Relevance 6.56
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
T cells 3
dorsal root ganglia 2
monocytes 1
Tnfrsf14 (Mus musculus)
Pain Link Frequency Relevance Heat
dorsal root ganglion 92 99.80 Very High Very High Very High
Pain 28 97.76 Very High Very High Very High
Etanercept 54 97.34 Very High Very High Very High
Arthritis 43 92.84 High High
Eae 6 91.32 High High
Pain score 2 86.84 High High
rheumatoid arthritis 6 85.92 High High
Hyperalgesia 48 84.00 Quite High
Inflammation 155 81.40 Quite High
cytokine 79 74.68 Quite High
Disease Link Frequency Relevance Heat
Cold Sores 373 100.00 Very High Very High Very High
Ganglion Cysts 92 99.32 Very High Very High Very High
Necrosis 25 98.32 Very High Very High Very High
Infection 314 98.28 Very High Very High Very High
Cancer 22 97.96 Very High Very High Very High
Pain 34 97.76 Very High Very High Very High
Arthritis 53 92.84 High High
Death 7 92.60 High High
Inflammatory Pain 4 91.32 High High
Appetite Loss 1 90.96 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
, and LIGHT (LT-like, exhibits inducible expression, and competes with HSV glycoprotein D for HVEM, a receptor expressed by T lymphocytes) are some of the more prominent ligands [58,223].
Gene_expression (expression) of HVEM in T lymphocytes associated with cold sores
1) Confidence 0.65 Published 2005 Journal Virol J Section Body Doc Link PMC1215526 Disease Relevance 0.79 Pain Relevance 0.11
HVEM is predominantly expressed by resting T cells, monocytes, immature dendritic cells (DC), and endothelial cells [13,14].
Gene_expression (expressed) of HVEM in T cells
2) Confidence 0.21 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965573 Disease Relevance 0.82 Pain Relevance 0.13
Transfer of HSV to T cells depends mainly on the binding of gD to its receptor, HVEM [36]. gD is expressed on the surface of activated T cells after infection [37].
Gene_expression (expressed) of HVEM in T cells associated with cold sores and infection
3) Confidence 0.21 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965573 Disease Relevance 1.49 Pain Relevance 0.06
HVEM is predominantly expressed by resting T cells, monocytes, immature dendritic cells (DC), and endothelial cells [13,14].
Gene_expression (expressed) of HVEM in monocytes
4) Confidence 0.07 Published 2010 Journal Molecular Vision Section Body Doc Link PMC2965573 Disease Relevance 0.82 Pain Relevance 0.13
The expression of TNF receptors (TNFRs) in dorsal root ganglia was measured using immunohistochemical analysis and polymerase chain reaction.
Gene_expression (expression) of TNFRs in dorsal root ganglia
5) Confidence 0.04 Published 2008 Journal Arthritis Rheum. Section Body Doc Link 18668541 Disease Relevance 0.18 Pain Relevance 0
YC contributed to the cloning and expression of the TNFRs and riboprobes.
Gene_expression (expression) of TNFRs
6) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1175031 Disease Relevance 0.80 Pain Relevance 0.17
The effects of an anti-TNF agent, etanercept, on behavioural pain responses arising from rat monoarthritis induced by complete Freund's adjuvant were assessed and compared with expression of TNF receptors (TNFRs) by dorsal root ganglion (DRG) cells at corresponding time points.
Gene_expression (expression) of TNFRs in DRG associated with ganglion cysts, dorsal root ganglion, pain and etanercept
7) Confidence 0.02 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1175031 Disease Relevance 1.65 Pain Relevance 0.98

General Comments

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