INT153719

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Context Info
Confidence 0.49
First Reported 2004
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 9.82
Pain Relevance 1.88

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (TEK) extracellular region (TEK) plasma membrane (TEK)
cytoskeleton (TEK) cell-cell signaling (TEK) cytoplasm (TEK)
Anatomy Link Frequency
endothelial cells 3
synovium 2
PSCs 1
fibroblast 1
TEK 1
TEK (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 223 99.84 Very High Very High Very High
Inflammation 194 98.64 Very High Very High Very High
cytokine 40 98.64 Very High Very High Very High
metalloproteinase 49 97.28 Very High Very High Very High
antagonist 7 91.44 High High
fibrosis 4 83.12 Quite High
COX2 2 83.04 Quite High
chemokine 89 79.60 Quite High
COX-2 inhibitor 12 79.60 Quite High
Chronic pancreatitis 1 57.24 Quite High
Disease Link Frequency Relevance Heat
Inflammatory Breast Neoplasms 284 99.84 Very High Very High Very High
Rheumatoid Arthritis 223 99.84 Very High Very High Very High
Synovitis 22 99.72 Very High Very High Very High
Arthritis 53 99.68 Very High Very High Very High
Osteoarthritis 21 98.80 Very High Very High Very High
INFLAMMATION 162 98.64 Very High Very High Very High
Hypoxia 92 98.64 Very High Very High Very High
Apoptosis 63 95.80 Very High Very High Very High
Cancer 225 94.12 High High
Aneuploidy 2 91.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the other hand, right branch shows overexpression areas with genes such as CASP 10, CD30-L, and CD-40-L (TNF family), ras-like small, FGF 3 and 5, TDGF1, ERK5, MIF, IFNGR2, MIG, IFN-alpha, beta, gamma, IL-3, -4, -9 and -13, IP-10, HPRT, DCC, TEK, netrin-2, cadherins 4, 8, 12 and 13 [33], MMP3, 8, 10, 12 and 13 (metalloproteinase), COL11A2, CCNG1, CDC-6, ATM, N-MYC, and p53.
Gene_expression (overexpression) of TEK in TEK associated with metalloproteinase
1) Confidence 0.49 Published 2005 Journal BMC Cancer Section Body Doc Link PMC1198222 Disease Relevance 0.79 Pain Relevance 0.05
Among the four epidermal growth factors, 18 angiogenic genes and six cytokines, only seven genes (namely IL-8, VEGF, bFGF, angiopoietin 1, flt-1, Tie-2 and Tie-1) are overexpressed in WIBC-9 when compared with non-inflammatory models [37].
Gene_expression (overexpressed) of Tie-2 associated with inflammation and cytokine
2) Confidence 0.42 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.26 Pain Relevance 0.20
PSCs expressed several angiogenesis-regulating molecules including VEGF receptors, angiopoietin-1, and Tie-2.
Gene_expression (expressed) of Tie-2 in PSCs
3) Confidence 0.39 Published 2008 Journal Am. J. Physiol. Gastrointest. Liver Physiol. Section Abstract Doc Link 18669622 Disease Relevance 1.43 Pain Relevance 0.20
Many highly expressed transcripts in eEPCs are haematopoietic specific (RUNX1, WAS, LYN) with links to immunity and inflammation (TLRs, CD14, HLAs), whereas many transcripts involved in vascular development and angiogenesis-related signalling pathways (Tie2, eNOS, Ephrins) are highly expressed in OECs.
Gene_expression (expressed) of Tie2 in OECs associated with inflammation
4) Confidence 0.32 Published 2010 Journal BMC Med Genomics Section Abstract Doc Link PMC2881111 Disease Relevance 0.10 Pain Relevance 0.05
In 1997, eEPCs were the first putative endothelial progenitors isolated in vitro by culturing CD34+ VEGFR2+ mononuclear blood cells on fibronectin [25] and confirming a subsequent increase in expression of endothelial cell-associated markers such as CD34, CD31, VEGFR2, Tie2, and E-selectin.
Gene_expression (expression) of Tie2 in endothelial cell
5) Confidence 0.32 Published 2010 Journal BMC Med Genomics Section Body Doc Link PMC2881111 Disease Relevance 0.18 Pain Relevance 0.05
Among nine angiogenic factors quantified by means of RT-PCR (vascular endothelial growth factor [VEGF], VEGFR1, VEGFR2, Ang-1, Ang-2, TIE-1, TIE-2, COX-2, and basic fibroblast growth factor [bFGF]), the same authors found that Ang-1, TIE-1, TIE-2, and bFGF were strongly expressed in IBC when compared with non-IBC [33].
Gene_expression (expressed) of TIE-2 in fibroblast associated with inflammatory breast neoplasms
6) Confidence 0.32 Published 2005 Journal Breast Cancer Res Section Body Doc Link PMC1064141 Disease Relevance 1.78 Pain Relevance 0.18
VEGF, HIF-1, Ang1, Tie2, and survivin are all expressed in the arthritic synovium [16,25].
Gene_expression (expressed) of Tie2 in synovium associated with arthritis
7) Confidence 0.21 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2592799 Disease Relevance 0.79 Pain Relevance 0.33
Similarly, the angiopoietins Ang1 and Ang2, and their cellular receptor Tie2, which are all widely expressed in RA synovitis, are regulated by both hypoxia and TNF-?
Gene_expression (expressed) of Tie2 associated with hypoxia, synovitis and rheumatoid arthritis
8) Confidence 0.18 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC1064874 Disease Relevance 1.18 Pain Relevance 0.32
A number of markers expressed by the MDA-MB-231 cells, including thrombin receptor, TIE-2, CD31, VEGF, and bc-48, have been shown to be associated with endothelial cells [30-34].
Gene_expression (expressed) of TIE-2 in endothelial cells
9) Confidence 0.14 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.77 Pain Relevance 0
Thus far, there has only been one report of VM in primary human IBC specimens in which the authors correlated VM with high expression of Flt-1 and TIE-2 and absence of CD31 and thrombin [7].
Gene_expression (expression) of TIE-2 associated with inflammatory breast neoplasms
10) Confidence 0.13 Published 2006 Journal Breast Cancer Res Section Body Doc Link PMC1797025 Disease Relevance 0.88 Pain Relevance 0.08
The expression of Tie-1 and Tie-2 has been reported in the RA synovium, and there is significant upregulation of Tie-1 on endothelial cells, on lining cells and on macrophages in RA compared with normal [87-89].
Gene_expression (expression) of Tie-2 in synovium associated with rheumatoid arthritis
11) Confidence 0.12 Published 2004 Journal Arthritis Res Ther Section Body Doc Link PMC400438 Disease Relevance 0.65 Pain Relevance 0.44

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