INT153723

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Context Info
Confidence 0.41
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.25
Pain Relevance 1.58

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (Hif1a) signal transduction (Hif1a) nucleolus (Hif1a)
nucleus (Hif1a) protein binding transcription factor activity (Hif1a) DNA binding (Hif1a)
Anatomy Link Frequency
liver 4
Hif1a (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 20 94.84 High High
Disease Link Frequency Relevance Heat
Hypoxia 3 100.00 Very High Very High Very High
Necrosis 3 100.00 Very High Very High Very High
Stress 1 92.80 High High
Hepatotoxicity 6 90.24 High High
Cancer 1 78.80 Quite High
Toxicity 4 75.00 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Histopathological and immunohistochemical analyses also demonstrated that SDS could reduce the appearance of necrosis regions as well as caspase-3 and hypoxia inducible factor-1alpha (HIF-1alpha) expression in liver tissue.
Negative_regulation (reduce) of Gene_expression (expression) of HIF-1alpha in liver associated with necrosis and hypoxia
1) Confidence 0.41 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18670083 Disease Relevance 0.65 Pain Relevance 0.95
Immunohistochemical analyses also demonstrated that AA could reduce the appearance of necrosis regions as well as caspase-3 and hypoxia inducible factor-1alpha (HIF-1alpha) expression in liver tissue.
Negative_regulation (reduce) of Gene_expression (expression) of HIF-1alpha in liver associated with necrosis and hypoxia
2) Confidence 0.41 Published 2010 Journal Phytomedicine Section Abstract Doc Link 19836221 Disease Relevance 0.61 Pain Relevance 0.63

General Comments

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