INT153725

Context Info Confidence 0.25 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 5 Disease Relevance 2.87 Pain Relevance 1.68

transport (Slc17a5) cytoplasmic membrane-bounded vesicle (Slc17a5) plasma membrane (Slc17a5) transmembrane transport (Slc17a5) lysosome (Slc17a5)

Anatomy Link Frequency liver 2 Slc17a5 (Mus musculus)

Pain Link Frequency Relevance Heat Paracetamol 19 100.00 Inflammation 5 87.68 Pain 1 86.64 fibrosis 28 45.20 dexamethasone 1 40.08 anesthesia 2 5.00 alcohol 2 5.00 ketamine 1 5.00 tolerance 1 5.00

Disease Link Frequency Relevance Heat Cancer 6 98.44 Necrosis 6 98.20 Hepatotoxicity 15 97.94 Injury 30 92.32 INFLAMMATION 5 87.68 Acute Liver Failure 1 87.24 Pain 1 86.64 Apoptosis 4 82.32 Hypoxia 1 81.60 Severe Combined Immunodeficiency 4 77.56

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As a result, pretreated with ASE prior to the administration of APAP significantly prevented the increases of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and tumor necrosis factor-alpha (TNF-alpha) levels in serum, and glutathione (GSH) depletion, malondialdehyde (MDA) accumulation in liver tissue.

Negative_regulation (prevented) of Positive_regulation (increases) of AST in liver associated with necrosis, paracetamol and cancer

1) Confidence 0.25 Published 2009 Journal Biol. Pharm. Bull. Section Abstract Doc Link 19801828 Disease Relevance 0.53 Pain Relevance 0.57

SDS significantly protected APAP-induced hepatotoxicity for SDS improved mouse survival rates better than NAC against a lethal dose of APAP and significantly blocked not only APAP-induced increases of AST, ALT, and TNF-alpha but also APAP-induced GSH depletion and MDA accumulation.

Negative_regulation (blocked) of Positive_regulation (increases) of AST associated with paracetamol and hepatotoxicity

2) Confidence 0.23 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18670083 Disease Relevance 0.66 Pain Relevance 0.98

In mice, pretreatment with AC prior to the administration of CCl4 significantly prevented the increased serum enzymatic activity of ALT and AST as well as the formation of hepatic malondialdehyde.

Negative_regulation (prevented) of Positive_regulation (increased) of AST

3) Confidence 0.12 Published 2009 Journal Food Chem. Toxicol. Section Abstract Doc Link 18984026 Disease Relevance 0.45 Pain Relevance 0.13

Intravenous administration of fucoidan attenuated this elevation of serum AST and ALT (304 and 214 karumen unit/ml, respectively, at 25 mg/kg fucoidan).

Negative_regulation (attenuated) of Positive_regulation (elevation) of serum AST

4) Confidence 0.08 Published 2008 Journal Eur J Pharmacol Section Body Doc Link PMC2258315 Disease Relevance 0.59 Pain Relevance 0

In G1 and G2 mice, the activity of serum ALT and AST showed initially significantly elevated and gradually decreased with time, and in the G1 mice, both ALT and AST presented significantly lower values when compared with the values found in G2 mice at the same time points (Table 1).

Negative_regulation (decreased) of Positive_regulation (elevated) of AST

5) Confidence 0.06 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2941114 Disease Relevance 0.64 Pain Relevance 0

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