INT153725

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Context Info
Confidence 0.25
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 5
Disease Relevance 2.87
Pain Relevance 1.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

transport (Slc17a5) cytoplasmic membrane-bounded vesicle (Slc17a5) plasma membrane (Slc17a5)
transmembrane transport (Slc17a5) lysosome (Slc17a5)
Anatomy Link Frequency
liver 2
Slc17a5 (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 19 100.00 Very High Very High Very High
Inflammation 5 87.68 High High
Pain 1 86.64 High High
fibrosis 28 45.20 Quite Low
dexamethasone 1 40.08 Quite Low
anesthesia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
tolerance 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 6 98.44 Very High Very High Very High
Necrosis 6 98.20 Very High Very High Very High
Hepatotoxicity 15 97.94 Very High Very High Very High
Injury 30 92.32 High High
INFLAMMATION 5 87.68 High High
Acute Liver Failure 1 87.24 High High
Pain 1 86.64 High High
Apoptosis 4 82.32 Quite High
Hypoxia 1 81.60 Quite High
Severe Combined Immunodeficiency 4 77.56 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
As a result, pretreated with ASE prior to the administration of APAP significantly prevented the increases of aspartate aminotransferase (AST), alanine aminotransferase (ALT), and tumor necrosis factor-alpha (TNF-alpha) levels in serum, and glutathione (GSH) depletion, malondialdehyde (MDA) accumulation in liver tissue.
Negative_regulation (prevented) of Positive_regulation (increases) of AST in liver associated with necrosis, paracetamol and cancer
1) Confidence 0.25 Published 2009 Journal Biol. Pharm. Bull. Section Abstract Doc Link 19801828 Disease Relevance 0.53 Pain Relevance 0.57
SDS significantly protected APAP-induced hepatotoxicity for SDS improved mouse survival rates better than NAC against a lethal dose of APAP and significantly blocked not only APAP-induced increases of AST, ALT, and TNF-alpha but also APAP-induced GSH depletion and MDA accumulation.
Negative_regulation (blocked) of Positive_regulation (increases) of AST associated with paracetamol and hepatotoxicity
2) Confidence 0.23 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18670083 Disease Relevance 0.66 Pain Relevance 0.98
In mice, pretreatment with AC prior to the administration of CCl4 significantly prevented the increased serum enzymatic activity of ALT and AST as well as the formation of hepatic malondialdehyde.
Negative_regulation (prevented) of Positive_regulation (increased) of AST
3) Confidence 0.12 Published 2009 Journal Food Chem. Toxicol. Section Abstract Doc Link 18984026 Disease Relevance 0.45 Pain Relevance 0.13
Intravenous administration of fucoidan attenuated this elevation of serum AST and ALT (304 and 214 karumen unit/ml, respectively, at 25 mg/kg fucoidan).
Negative_regulation (attenuated) of Positive_regulation (elevation) of serum AST
4) Confidence 0.08 Published 2008 Journal Eur J Pharmacol Section Body Doc Link PMC2258315 Disease Relevance 0.59 Pain Relevance 0
In G1 and G2 mice, the activity of serum ALT and AST showed initially significantly elevated and gradually decreased with time, and in the G1 mice, both ALT and AST presented significantly lower values when compared with the values found in G2 mice at the same time points (Table 1).


Negative_regulation (decreased) of Positive_regulation (elevated) of AST
5) Confidence 0.06 Published 2010 Journal Stem Cell Res Ther Section Body Doc Link PMC2941114 Disease Relevance 0.64 Pain Relevance 0

General Comments

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