INT153728

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 3
Total Number 3
Disease Relevance 2.01
Pain Relevance 2.36

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytoplasm (RYBP, Gpt) nucleoplasm (RYBP) biosynthetic process (Gpt)
nucleus (RYBP) intracellular (RYBP) DNA binding (RYBP)
Anatomy Link Frequency
plasma 1
RYBP (Homo sapiens)
Gpt (Mus musculus)
Pain Link Frequency Relevance Heat
Paracetamol 104 100.00 Very High Very High Very High
Inflammatory mediators 1 92.28 High High
Inflammation 4 87.96 High High
Analgesic 2 79.16 Quite High
cytokine 3 72.16 Quite High
withdrawal 1 65.36 Quite High
Potency 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hepatotoxicity 15 97.60 Very High Very High Very High
Toxicity 7 93.36 High High
INFLAMMATION 5 91.88 High High
Necrosis 6 86.84 High High
Cancer 3 86.48 High High
Hypoxia 1 82.00 Quite High
Drug-induced Liver Injury 3 66.24 Quite High
Acute Liver Failure 1 63.00 Quite High
Injury 11 5.00 Very Low Very Low Very Low
Stress 9 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SDS significantly protected APAP-induced hepatotoxicity for SDS improved mouse survival rates better than NAC against a lethal dose of APAP and significantly blocked not only APAP-induced increases of AST, ALT, and TNF-alpha but also APAP-induced GSH depletion and MDA accumulation.
APAP-induced Positive_regulation (increases) of ALT associated with paracetamol and hepatotoxicity
1) Confidence 0.03 Published 2008 Journal Biol. Pharm. Bull. Section Abstract Doc Link 18670083 Disease Relevance 0.66 Pain Relevance 0.97
We found that, pre-treatment with TNF-alpha resulted in approximately 50 to 60% increase in alanine aminotransferase (ALT) levels by APAP or CPZ, while interleukin-1beta (IL-1beta) or IL6 treatments showed only 15-20% increase in ALT release.
APAP Positive_regulation (increase) of ALT associated with paracetamol
2) Confidence 0.01 Published 2010 Journal J Toxicol Sci Section Abstract Doc Link 20371967 Disease Relevance 1.35 Pain Relevance 1.11
As shown in Figure 1, APAP elevated the plasma ALT, AST and LDH by 64%, 135% and 292% above control, respectively (all differences at p<0.001 vs. control).
APAP Positive_regulation (elevated) of ALT in plasma associated with paracetamol
3) Confidence 0.00 Published 2010 Journal J Biomed Sci Section Body Doc Link PMC2994383 Disease Relevance 0 Pain Relevance 0.28

General Comments

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