INT153731

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Context Info
Confidence 0.32
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 2.00
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

immune system process (Ahr) cell morphogenesis (Ahr) DNA binding (Ahr)
response to stress (Ahr) cytoplasm (Ahr) signal transducer activity (Ahr)
Ahr (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Pain 2 97.56 Very High Very High Very High
corticosteroid 18 84.24 Quite High
agonist 19 48.40 Quite Low
antagonist 14 5.00 Very Low Very Low Very Low
tolerance 6 5.00 Very Low Very Low Very Low
Inflammation 5 5.00 Very Low Very Low Very Low
qutenza 2 5.00 Very Low Very Low Very Low
Inflammatory mediators 2 5.00 Very Low Very Low Very Low
depression 1 5.00 Very Low Very Low Very Low
headache 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Sickle Cell Anemia 9 98.16 Very High Very High Very High
Acute Chest Syndrome 3 97.84 Very High Very High Very High
Pain 2 97.56 Very High Very High Very High
Asthma 60 95.48 Very High Very High Very High
Airway Obstruction 14 79.12 Quite High
Pulmonary Disease 4 45.88 Quite Low
Rhinitis 2 31.60 Quite Low
Dyspnea 14 5.00 Very Low Very Low Very Low
Syndrome 8 5.00 Very Low Very Low Very Low
INFLAMMATION 7 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Evaluation of AHR with methacholine challenge in patients with SCD appears to be well tolerated and may elucidate a cause of SCD morbidity.
Positive_regulation (Evaluation) of Gene_expression (Evaluation) of AHR associated with sickle cell anemia
1) Confidence 0.32 Published 2008 Journal Pediatr. Pulmonol. Section Abstract Doc Link 18671275 Disease Relevance 1.01 Pain Relevance 0.19
EIB is considered a form of airway hyperresponsiveness (AHR) and its expression increases and decreases in relationship to the degree of underlying airway reactivity9 and the severity of the underlying asthma.10 The importance of AHR in EIB and asthma was emphasized by a recent study which showed that children with increased airway responsiveness in late infancy and childhood had a greater risk of developing asthma than their counterparts who did not have increased airway responsiveness in infancy.11
Positive_regulation (increases) of Gene_expression (expression) of AHR associated with asthma
2) Confidence 0.02 Published 2009 Journal Therapeutics and Clinical Risk Management Section Body Doc Link PMC2789687 Disease Relevance 1.00 Pain Relevance 0.09

General Comments

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