INT153734

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Context Info
Confidence 0.52
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 0.23
Pain Relevance 3.25

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (Gria3) protein complex (Gria3)
Anatomy Link Frequency
hypothalamus 1
brain 1
caudate putamen 1
striatum 1
prefrontal 1
Gria3 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Glutamate 116 100.00 Very High Very High Very High
Glutamate receptor 17 100.00 Very High Very High Very High
nMDA receptor 36 99.88 Very High Very High Very High
Hippocampus 36 98.52 Very High Very High Very High
amygdala 12 97.32 Very High Very High Very High
Morphine 16 95.56 Very High Very High Very High
antagonist 49 93.12 High High
Neurotransmitter 16 91.16 High High
Nucleus accumbens 52 90.48 High High
5HT 16 78.20 Quite High
Disease Link Frequency Relevance Heat
Drug Dependence 16 64.44 Quite High
Schizophrenia 20 63.68 Quite High
Disease 6 51.16 Quite High
Death 4 48.64 Quite Low
Adenoma 5 39.24 Quite Low
Attention Deficit Hyperactivity Disorder 1 15.44 Low Low
Amnesia 8 14.72 Low Low
Cognitive Disorder 20 13.60 Low Low
Depression 6 12.84 Low Low
Hallucination 8 12.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In order to evaluate the mechanism underlying the behavioural responses, quantitative real-time reverse transcription-polymerase chain reaction was used to evaluate mRNA expression of the AMPA receptor subunits GluR2 and GluR3 in the striatum, prefrontal cortex, hippocampus, hypothalamus and amygdala of animals treated repeatedly with morphine. 3.
Transcription (expression) of GluR3 in striatum associated with hippocampus, amygdala and morphine
1) Confidence 0.52 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18671727 Disease Relevance 0 Pain Relevance 0.80
In the hypothalamus, the mRNA levels of GluR1, GluR3, mGluR1, mGluR3 and NR1 were significantly increased also after the administration of the highest MDMA dose, Figure 2C.
Transcription (levels) of GluR3 in hypothalamus
2) Confidence 0.27 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0 Pain Relevance 0
In the caudate putamen, mRNA levels of GluR3, NR2A, and NR2B receptor subunits were significantly increased.
Transcription (levels) of GluR3 in caudate putamen
3) Confidence 0.27 Published 2008 Journal BMC Neurosci Section Abstract Doc Link PMC2358913 Disease Relevance 0.13 Pain Relevance 0.38
In the CPU, MDMA high significantly enhanced mRNA levels of the AMPA subunit GluR3, NMDA subunits NR2A and NR2B, Figure 1C.
Transcription (levels) of GluR3
4) Confidence 0.24 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0 Pain Relevance 0
Glutamate or certain aspartate analogues have been found to stimulate PRL, GH and LH release and rat anterior pituitary cells express mRNA of glutamate receptors GluR1, GluR2, GluR3, GluR4, GluR5, GluR6, GluR7, KA1 and KA2 subunits (765).
Transcription (express) of GluR3 in anterior pituitary associated with glutamate and glutamate receptor
5) Confidence 0.23 Published 2008 Journal Journal of Neuroendocrinology Section Body Doc Link PMC2229370 Disease Relevance 0 Pain Relevance 0.61
In order to evaluate the mechanism underlying the behavioural responses, quantitative real-time reverse transcription-polymerase chain reaction was used to evaluate mRNA expression of the AMPA receptor subunits GluR2 and GluR3 in the striatum, prefrontal cortex, hippocampus, hypothalamus and amygdala of animals treated repeatedly with morphine. 3.
Transcription (expression) of GluR3 in prefrontal associated with hippocampus, amygdala and morphine
6) Confidence 0.18 Published 2008 Journal Clin. Exp. Pharmacol. Physiol. Section Abstract Doc Link 18671727 Disease Relevance 0 Pain Relevance 0.80
The mRNA levels of glutamate transporters (EAAT1, EAAT2-1, EAAT2-2), AMPA receptor subunits (GluR1, GluR2, GluR3), NMDA receptor subunits (NR1, NR2A and NR2B), as well as metabotropic glutamate receptors (mGluR1, mGluR2, mGluR3, mGluR5) were confirmed in six regions of the male rat brain (the prefrontal cortex (PFC), cortex, caudate putamen (CPU), nucleus accumbens (Acb), hippocampus and hypothalamus.
Transcription (levels) of GluR3 in brain associated with nucleus accumbens, glutamate, glutamate receptor, nmda receptor and hippocampus
7) Confidence 0.12 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2358913 Disease Relevance 0.11 Pain Relevance 0.67

General Comments

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