INT153757

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Context Info
Confidence 0.46
First Reported 2007
Last Reported 2011
Negated 0
Speculated 0
Reported most in Body
Documents 10
Total Number 11
Disease Relevance 8.38
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Mitf) cell differentiation (Mitf) nucleus (Mitf)
protein complex assembly (Mitf) DNA binding (Mitf) protein complex (Mitf)
Anatomy Link Frequency
mast cells 3
melanocytes 2
SK-MEL-28 1
granulocytes 1
monocytes 1
Mitf (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 247 98.52 Very High Very High Very High
iatrogenic 1 92.44 High High
cytokine 21 84.80 Quite High
ischemia 14 81.72 Quite High
Inflammatory mediators 7 81.52 Quite High
backache 1 72.00 Quite High
Inflammatory response 47 47.12 Quite Low
substance P 15 23.36 Low Low
interstitial cystitis 20 5.44 Low Low
melanocortin 1 receptor 78 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microphthalmia 126 100.00 Very High Very High Very High
Myocardial Infarction 46 99.64 Very High Very High Very High
Low Back Pain 7 99.32 Very High Very High Very High
INFLAMMATION 316 98.52 Very High Very High Very High
Leukemia 6 96.72 Very High Very High Very High
Injury 33 93.64 High High
Neurodegenerative Disease 1 93.54 High High
Cicatrix 40 93.28 High High
Renal Cancer 15 91.56 High High
Skin Cancer 10 90.16 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
MiTF mRNA and protein levels are higher in human mast cells than monocytes and granulocytes [55].
Positive_regulation (higher) of MiTF in granulocytes associated with microphthalmia
1) Confidence 0.46 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 1.32 Pain Relevance 0
Hierarchical clustering using only the 106 transcripts identified by class comparison revealed two main expression motifs in the melanoma cell lines (Figure 1A): Motif 1 distinguished eight cell lines (NZM09, NZM11, NZM19, NZM22, NZM40, NZM52, SK-MEL-28, UACC62), and consisted of down-regulation of genes involved in neural crest and melanocyte development, differentiation, and pigmentation (e.g., EDNRB, MITF, MLANA, TYR; Table S1), and up-regulation of genes related to angiogenesis, neurogenesis, immunomodulation, and interaction and remodelling of the extracellular environment (e.g., HIF1a, NRP1, PLAUR, TGFBI; Table S1); Motif 2 distinguished the remaining 19 cell lines, and showed a pattern of gene expression that tended to be the inverse of Motif 1, with down-regulation of extracellular remodelling genes and up-regulation of MITF and melanocyte lineage markers, although not all Motif 2 cell lines had higher levels of MITF expression (e.g.
Positive_regulation (up-regulation) of MITF in SK-MEL-28 associated with melanoma and neurodegenerative disease
2) Confidence 0.45 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2794539 Disease Relevance 0.38 Pain Relevance 0
The results in 40 consecutive patients who underwent MI-TLIF for symptomatic spondylolisthesis utilizing this approach are reviewed.
Positive_regulation (underwent) of MI-TLIF associated with low back pain
3) Confidence 0.31 Published 2008 Journal Neurosurg Focus Section Abstract Doc Link 18673045 Disease Relevance 0.59 Pain Relevance 0.12
As a result of increased of MiTF activity in mast cells there is mMCP-6 and mMCP-7 synthesis, leading to additional signals for inflammation.
Positive_regulation (increased) of MiTF in mast cells associated with inflammation and microphthalmia
4) Confidence 0.31 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.76 Pain Relevance 0.29
To the best of our knowledge, this is the first report describing TFEB expression in response to PAR activation in the bladder and suggest a unifying, mechanistic pathway of bladder inflammation as follows: we hypothesize that mast cells release tryptase resulting in increased PAR activation and, consequently, TFEB/MiTF activity.
Positive_regulation (increased) of MiTF in mast cells associated with inflammation and microphthalmia
5) Confidence 0.31 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.76 Pain Relevance 0.29
To the best of our knowledge, this is the first report describing TFEB expression in response to PAR activation in the bladder and suggest a unifying, mechanistic pathway of bladder inflammation as follows: we hypothesize that mast cells release tryptase resulting in increased PAR activation and, consequently, TFEB/MiTF activity.
Positive_regulation (activation) of MiTF in mast cells associated with inflammation and microphthalmia
6) Confidence 0.31 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 0.76 Pain Relevance 0.29
Next, ligand-bound Kit stimulates a pathway activating transcription factor Microphthalmia (Mitf), which promotes differentiation and survival of melanocytes by activating expression of Tyrosinase family members, Bcl2, and other genes.
Positive_regulation (activating) of Mitf in melanocytes associated with microphthalmia
7) Confidence 0.29 Published 2010 Journal PLoS Genetics Section Abstract Doc Link PMC2940735 Disease Relevance 0.29 Pain Relevance 0
MiTF mRNA and protein levels are higher in human mast cells than monocytes and granulocytes [55].
Positive_regulation (higher) of MiTF in monocytes associated with microphthalmia
8) Confidence 0.16 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 1.32 Pain Relevance 0
Mc1r binding leads to activation of downstream effectors in the pigmentation pathway, including the target gene mitf, which is transcriptionally upregulated by cAMP signaling in melanocytes [22].
Positive_regulation (upregulated) of mitf in melanocytes
9) Confidence 0.10 Published 2009 Journal PLoS Genetics Section Body Doc Link PMC2603666 Disease Relevance 0.08 Pain Relevance 0
Tenascin C and osteopontin-1 showed delayed induction in cMI.
Positive_regulation (induction) of cMI
10) Confidence 0.01 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2997608 Disease Relevance 1.06 Pain Relevance 0.12
The mRNA of proinflammatory mediators was transiently induced in MI and persistently upregulated in cMI.
Positive_regulation (upregulated) of cMI associated with myocardial infarction
11) Confidence 0.01 Published 2011 Journal Journal of Biomedicine and Biotechnology Section Abstract Doc Link PMC2997608 Disease Relevance 1.07 Pain Relevance 0.12

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