INT153758

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Context Info
Confidence 0.47
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 5
Disease Relevance 2.50
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

pigmentation (Mitf) cell differentiation (Mitf) nucleus (Mitf)
protein complex assembly (Mitf) DNA binding (Mitf) protein complex (Mitf)
Anatomy Link Frequency
eyes 1
macrophages 1
monocytes 1
Mitf (Mus musculus)
Pain Link Frequency Relevance Heat
iatrogenic 1 92.44 High High
Inflammation 47 75.28 Quite High
cytokine 7 74.24 Quite High
backache 1 72.00 Quite High
Inflammatory response 9 67.44 Quite High
interstitial cystitis 4 5.00 Very Low Very Low Very Low
substance P 3 5.00 Very Low Very Low Very Low
Inflammatory stimuli 3 5.00 Very Low Very Low Very Low
analgesia 2 5.00 Very Low Very Low Very Low
cva 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Microphthalmia 24 100.00 Very High Very High Very High
Low Back Pain 7 99.32 Very High Very High Very High
Deafness 1 98.00 Very High Very High Very High
Injury 4 93.64 High High
Hypercalcemia 5 82.88 Quite High
Renal Cancer 3 76.00 Quite High
INFLAMMATION 56 75.28 Quite High
Genetic Translocation 1 71.36 Quite High
Sepsis 68 69.76 Quite High
Systemic Inflammatory Response Syndrome 2 68.16 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
1,25 (OH)2 vitamin D3 regulates the differentiation from stem cells towards monocytes and macrophages by interacting with specific vitamin D receptors in the myeloid tissue cells 9,10.
vit Binding (interacting) of in macrophages
1) Confidence 0.47 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1925152 Disease Relevance 0.27 Pain Relevance 0.14
Each protein of the MiTF family forms homo- or heterodimers with other family members [50] and recognizes, in general, the same DNA sequences [51].
MiTF Binding (recognizes) of associated with microphthalmia
2) Confidence 0.32 Published 2007 Journal BMC Immunol Section Body Doc Link PMC2000913 Disease Relevance 1.09 Pain Relevance 0.06
The homozygote mutation at the mitf locus affects the ability of the mitf protein to bind DNA and induces small eyes, a devoid of pigment, deaf at an early age, a decrease of mast cells and immunological defects.
mitf Binding (bind) of in eyes associated with deafness
3) Confidence 0.31 Published 2010 Journal The Open Dentistry Journal Section Body Doc Link PMC2835863 Disease Relevance 0.27 Pain Relevance 0
The results in 40 consecutive patients who underwent MI-TLIF for symptomatic spondylolisthesis utilizing this approach are reviewed.
MI-TLIF Binding (underwent) of associated with low back pain
4) Confidence 0.25 Published 2008 Journal Neurosurg Focus Section Abstract Doc Link 18673045 Disease Relevance 0.59 Pain Relevance 0.12
1,25 (OH)2 vitamin D3 regulates the differentiation from stem cells towards monocytes and macrophages by interacting with specific vitamin D receptors in the myeloid tissue cells 9,10.
vit Binding (interacting) of in monocytes
5) Confidence 0.16 Published 2007 Journal International Journal of Medical Sciences Section Body Doc Link PMC1925152 Disease Relevance 0.27 Pain Relevance 0.14

General Comments

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