INT153770

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Context Info
Confidence 0.18
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 2
Disease Relevance 1.04
Pain Relevance 0.70

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Ctsa) nucleolus (Ctsa) nucleus (Ctsa)
molecular_function (Ctsa) cellular_component (Ctsa) biological_process (Ctsa)
Ctsa (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Lasting pain 4 88.16 High High
Spinal cord 19 85.04 High High
allodynia 4 82.36 Quite High
Neuropathic pain 10 78.12 Quite High
Osteoarthritis 2 75.00 Quite High
Pain 10 70.24 Quite High
Inflammation 4 68.72 Quite High
Peripheral nerve injury 1 63.48 Quite High
Hyperalgesia 2 62.80 Quite High
diclofenac 1 55.40 Quite High
Disease Link Frequency Relevance Heat
Disease 7 96.12 Very High Very High Very High
Pain 14 87.28 High High
Neuropathic Pain 17 82.36 Quite High
Osteoarthritis 2 75.00 Quite High
Motor Neuron Diseases 1 73.04 Quite High
INFLAMMATION 4 68.72 Quite High
Nervous System Injury 1 63.48 Quite High
Hyperalgesia 2 62.80 Quite High
Hemorrhage 1 35.20 Quite Low
Ulcers 1 34.64 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This apparent contradiction might be explained by either an increase of the active form of CATX, that is still below the detection level of the Western Blot, or a concomitant regulation of endogenous cathepsin inhibitors, the cystatins or thyropins [34,35].
Negative_regulation (regulation) of Negative_regulation (inhibitors) of cathepsin
1) Confidence 0.18 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2527007 Disease Relevance 0.79 Pain Relevance 0.58
Additional compounds including receptor activator of NF-kappaB (RANK) ligand inhibitors, cathepsin K inhibitors, bisphosphonates are further assessed regarding their potential structure-modifying effect.
Negative_regulation (inhibitors) of Negative_regulation (inhibitors) of cathepsin K
2) Confidence 0.04 Published 2008 Journal Osteoarthr. Cartil. Section Abstract Doc Link 18674931 Disease Relevance 0.25 Pain Relevance 0.12

General Comments

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