INT153772

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Context Info
Confidence 0.54
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 4.42
Pain Relevance 0.27

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (ESR1) enzyme binding (ESR1) DNA binding (ESR1)
protein complex (ESR1) cytoplasm (ESR1) signal transduction (ESR1)
Anatomy Link Frequency
body 2
ESR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
methotrexate 5 95.64 Very High Very High Very High
agonist 19 91.44 High High
antagonist 10 74.28 Quite High
spinal inflammation 2 50.00 Quite Low
rheumatoid arthritis 21 31.84 Quite Low
cytokine 16 5.00 Very Low Very Low Very Low
Inflammation 13 5.00 Very Low Very Low Very Low
imagery 5 5.00 Very Low Very Low Very Low
Potency 4 5.00 Very Low Very Low Very Low
corticosteroid 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Adenocarcinoma 9 99.80 Very High Very High Very High
Breast Cancer 214 99.20 Very High Very High Very High
Obesity 19 98.64 Very High Very High Very High
Reprotox - General 1 17 96.68 Very High Very High Very High
Anorexia 10 96.40 Very High Very High Very High
Body Weight 1 94.56 High High
Lung Cancer 1 93.04 High High
Skin Cancer 2 92.52 High High
Cancer 121 91.08 High High
Mycobacterial Infection 49 89.88 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
protein level (Figures 4c and 5a) through increased protein degradation (Figure 5b) and decreased abundance of ER?
Negative_regulation (decreased) of Localization (abundance) of ER
1) Confidence 0.54 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.27 Pain Relevance 0.15
Because TCZ can suppress elevation of CRP and ESR, it is inadequate to evaluate its effectiveness by clinical scores.
Negative_regulation (suppress) of Localization (elevation) of ESR
2) Confidence 0.41 Published 2009 Journal Mod Rheumatol Section Body Doc Link PMC2720589 Disease Relevance 1.00 Pain Relevance 0.05
Similarities include observations that these agents inhibit the ligand-induced nuclear translocation of ER?
Negative_regulation (inhibit) of Localization (translocation) of ER
3) Confidence 0.40 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.41 Pain Relevance 0.08
/PR negative breast cancer.50 Further studies will be required to establish the value of ER?
Negative_regulation (establish) of Localization (value) of ER associated with breast cancer
4) Confidence 0.30 Published 2010 Journal Clinical Medicine Insights. Oncology Section Body Doc Link PMC2883240 Disease Relevance 0.84 Pain Relevance 0
Our results show, for the first time, that TRPM8 protein is over-expressed in human breast adenocarcinomas and that this over-expression is specifically correlated with ER?
Negative_regulation (this) of Localization (correlated) of ER associated with adenocarcinoma
5) Confidence 0.24 Published 2010 Journal BMC Cancer Section Body Doc Link PMC2887400 Disease Relevance 1.13 Pain Relevance 0
Serum MMP-3 decreased significantly (P=0.04); significant decreases were also noted for the ESR, CRP, and BASDAI.
Negative_regulation (decreases) of Localization (noted) of ESR
6) Confidence 0.22 Published 2008 Journal Joint Bone Spine Section Body Doc Link 18674944 Disease Relevance 0 Pain Relevance 0
sedimentation rate (ESR), and body temperature were measured
Negative_regulation (measured) of Localization (temperature) of ESR in body
7) Confidence 0.05 Published 2007 Journal Mediators of Inflammation Section Body Doc Link PMC1804295 Disease Relevance 0.78 Pain Relevance 0

General Comments

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