INT153775

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Context Info
Confidence 0.52
First Reported 2005
Last Reported 2008
Negated 0
Speculated 1
Reported most in Body
Documents 9
Total Number 10
Disease Relevance 5.44
Pain Relevance 1.90

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (CTSK) extracellular space (CTSK) lysosome (CTSK)
cytoplasm (CTSK)
CTSK (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 224 100.00 Very High Very High Very High
Osteoarthritis 39 95.36 Very High Very High Very High
Inflammation 43 94.44 High High
cytokine 12 92.12 High High
Leflunomide 24 81.76 Quite High
methotrexate 16 73.64 Quite High
metalloproteinase 8 64.48 Quite High
antagonist 2 50.00 Quite Low
spinal inflammation 2 50.00 Quite Low
visual analogue scale 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 224 100.00 Very High Very High Very High
Necrosis 16 99.50 Very High Very High Very High
Cancer 17 99.32 Very High Very High Very High
Hypercalcemia 59 96.56 Very High Very High Very High
Disease 111 96.40 Very High Very High Very High
Osteoarthritis 48 95.36 Very High Very High Very High
Metastasis 24 94.56 High High
INFLAMMATION 45 94.44 High High
Osteoporosis 30 93.44 High High
Low Back Pain 2 50.00 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
and tumour necrosis factor alpha due to the increase of cathepsin K-expressing cells, proves this protease to be a valuable tool for bone research, and cathepsin K also may become a new and highly specific biomarker for RA [26].
Positive_regulation (increase) of cathepsin K associated with necrosis, cancer and rheumatoid arthritis
1) Confidence 0.52 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 0.68 Pain Relevance 0.13
The upregulation of cathepsin K and the correlation with the Larsen score as a parameter for radiological changes (Table 5) mirrors the destruction of bone structures in inflammatory diseases like RA.
Positive_regulation (upregulation) of cathepsin K associated with inflammation, rheumatoid arthritis and disease
2) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 0.75 Pain Relevance 0.29
The cathepsin K serum levels of the patients with RA (median first–third quartile range, 54.8 pmol/l) compared with the healthy control group (median first–third quartile range, 12.7 pmol/l) were significantly elevated (P = 0.0003) (Table 4).
Positive_regulation (elevated) of cathepsin K associated with rheumatoid arthritis
3) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 0.10 Pain Relevance 0.05
Our results demonstrate that cathepsin K is elevated in the serum of patients with RA compared with that of a healthy control group (Table 4).
Positive_regulation (elevated) of cathepsin K associated with rheumatoid arthritis
4) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 0.73 Pain Relevance 0.29
We found increased levels of cathepsin K compared with a healthy control group and found a significant correlation with radiological destruction, measured by the Larsen score.
Positive_regulation (increased) of cathepsin K
5) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Abstract Doc Link PMC1064888 Disease Relevance 0.63 Pain Relevance 0.18
Further studies should investigate whether elevated cathepsin K levels precede osseous destruction or whether they occur as result of them.
Spec (whether) Positive_regulation (elevated) of cathepsin K
6) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 0.79 Pain Relevance 0.28
This is the first study that demonstrates increased cathepsin K levels in the serum of patients with RA.
Positive_regulation (increased) of cathepsin K associated with rheumatoid arthritis
7) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 0.84 Pain Relevance 0.33
In vivo the activation of cathepsin K occurs intracellularly, before secretion into the resorbing lacunae and the onset of bone resorption, whereby local factors may regulate the processing of procathepsin K to mature cathepsin K [23].
Positive_regulation (activation) of cathepsin K associated with hypercalcemia
8) Confidence 0.35 Published 2005 Journal Arthritis Res Ther Section Body Doc Link PMC1064888 Disease Relevance 0.47 Pain Relevance 0.15
Serum MMP-3 levels were significantly higher in the patients than in the controls (4.71 vs. 2.79 ng/ml, P=0.04); levels were also higher for cathepsin K (6.4 vs. 3.6 pg/ml) and IL-17 (60.4 vs. 32 pg/ml), but the differences were not statistically significant.
Positive_regulation (higher) of cathepsin K
9) Confidence 0.31 Published 2008 Journal Joint Bone Spine Section Body Doc Link 18674944 Disease Relevance 0 Pain Relevance 0
Such disturbance could be due to an upregulation of the proteases, including MMP-13 and cathepsin K, which are potent bone resorptive factors [25-30].
Positive_regulation (upregulation) of cathepsin K
10) Confidence 0.08 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2483463 Disease Relevance 0.45 Pain Relevance 0.20

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