INT153776

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Context Info
Confidence 0.64
First Reported 2003
Last Reported 2010
Negated 1
Speculated 1
Reported most in Body
Documents 42
Total Number 46
Disease Relevance 34.58
Pain Relevance 14.82

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (IL17A) cell death (IL17A) extracellular region (IL17A)
cell-cell signaling (IL17A)
Anatomy Link Frequency
lymphocytes 4
neutrophils 4
T cells 3
leukocyte 2
lung 2
IL17A (Homo sapiens)
Pain Link Frequency Relevance Heat
rheumatoid arthritis 1004 100.00 Very High Very High Very High
cytokine 794 100.00 Very High Very High Very High
Inflammation 775 100.00 Very High Very High Very High
metalloproteinase 338 100.00 Very High Very High Very High
chemokine 165 100.00 Very High Very High Very High
spinal inflammation 9 99.84 Very High Very High Very High
Arthritis 597 99.62 Very High Very High Very High
Osteoarthritis 146 97.96 Very High Very High Very High
methotrexate 97 97.68 Very High Very High Very High
corticosteroid 45 97.36 Very High Very High Very High
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 1307 100.00 Very High Very High Very High
INFLAMMATION 835 100.00 Very High Very High Very High
Vasculitis 63 99.88 Very High Very High Very High
Seronegative Spondarthritis 51 99.84 Very High Very High Very High
Severe Combined Immunodeficiency 3 99.68 Very High Very High Very High
Acquired Immune Deficiency Syndrome Or Hiv Infection 197 99.66 Very High Very High Very High
Keloid Scars 310 99.60 Very High Very High Very High
Immune Reconstitution Inflammatory Syndrome 888 99.58 Very High Very High Very High
Cryptococcal Meningitis 408 99.48 Very High Very High Very High
Disease 558 99.38 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This is in accordance with our own results; we observed an increased level of IL-17 in RA patients with less than 6 weeks of disease duration, whereas in patients with established RA, the levels were not significantly different from those of healthy controls.
Positive_regulation (increased) of IL-17 associated with rheumatoid arthritis and disease
1) Confidence 0.64 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991033 Disease Relevance 1.19 Pain Relevance 0.63
We found that VERA patients had significantly higher levels of IL-17A when compared with healthy controls, but not with VEA patients (Figure 2a).
Positive_regulation (levels) of IL-17A associated with rheumatoid arthritis and arthritis
2) Confidence 0.64 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991033 Disease Relevance 1.33 Pain Relevance 0.87
Moreover, IL-17A was significantly increased locally within the joints of patients with established RA in comparison with control SF from patients with OA (Figure 2b).


Positive_regulation (increased) of IL-17A in joints associated with rheumatoid arthritis and osteoarthritis
3) Confidence 0.64 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991033 Disease Relevance 1.29 Pain Relevance 0.87
Despite the fact that we found significant increases in Th17 and IL-17+IFN?
Positive_regulation (increases) of IL-17
4) Confidence 0.64 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.72 Pain Relevance 0.28
The current study demonstrates that, in previously healthy human volunteers, exposure to organic dust substantially increases the messenger RNA for IL-17A in BAL cells.
Positive_regulation (increases) of IL-17A
5) Confidence 0.58 Published 2005 Journal Respir Res Section Body Doc Link PMC1166577 Disease Relevance 0.07 Pain Relevance 0.22
In conclusion, supported by our recent study showing a corresponding increase in free, soluble IL-17A protein [13], the current study adds novel evidence for organic dust inducing de novo synthesis of IL-17A protein in a subset of local lymphocytes within the human bronchoalveolar space.
Positive_regulation (increase) of IL-17A in lymphocytes
6) Confidence 0.58 Published 2005 Journal Respir Res Section Body Doc Link PMC1166577 Disease Relevance 0.32 Pain Relevance 0.13
At the same time point after the exposure, the MMP-9 expression in neutrophils was associated with an increase in mRNA for IL-17A, even though the fraction (percentage) of neutrophils expressing MMP-9 was not increased.
Positive_regulation (increase) of IL-17A in neutrophils associated with metalloproteinase
7) Confidence 0.58 Published 2005 Journal Respir Res Section Body Doc Link PMC1166577 Disease Relevance 0.08 Pain Relevance 0.31
Indeed, our current results are supported by our previous demonstration of an increase in the final consequence of the increased transcription and intracellular loading of protein, namely in free, soluble IL-17A protein in cell-free BAL fluid [13].
Positive_regulation (increase) of IL-17A
8) Confidence 0.58 Published 2005 Journal Respir Res Section Body Doc Link PMC1166577 Disease Relevance 0.12 Pain Relevance 0.09
The demonstrated increase in IL-17A mRNA is associated with an increased absolute number of MMP-9 expressing BAL neutrophils at the same time point.
Positive_regulation (increase) of IL-17A mRNA in neutrophils associated with metalloproteinase
9) Confidence 0.58 Published 2005 Journal Respir Res Section Body Doc Link PMC1166577 Disease Relevance 0.15 Pain Relevance 0.25
This suggests that the presence of IL-17 producing CD4+ T cells in the blood from patients with established RA is of limited use as a biomarker to indicate disease activity.
Positive_regulation (presence) of IL-17 in T cells associated with disease and arthritis
10) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.82 Pain Relevance 0.32
We also found highly significant increases in Th1 and IL-17+IFN?
Positive_regulation (increases) of IL-17
11) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.62 Pain Relevance 0.31
Interestingly, of six patients, the four patients with active disease (DAS28>3.2) had a much higher percentage of IL-17+IFN?
Positive_regulation (percentage) of IL-17 associated with disease
12) Confidence 0.46 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2931706 Disease Relevance 0.40 Pain Relevance 0.11
Having found that IL-17A was elevated in VERA patients, we decided to quantify a panel of cytokines known to be associated with Th17 polarization.
Positive_regulation (elevated) of IL-17A associated with rheumatoid arthritis and cytokine
13) Confidence 0.43 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2991033 Disease Relevance 1.25 Pain Relevance 0.85
The fact that the increased IL-17A mRNA is associated with an increased number of MMP-9-expressing neutrophils is compatible with IL-17A increasing the local proteolytic burden through its neutrophil-accumulating effect.



Positive_regulation (increased) of IL-17A mRNA in neutrophil
14) Confidence 0.39 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1166577 Disease Relevance 0.06 Pain Relevance 0.03
In the current study, we determined whether mRNA for IL-17A is elevated and protein expression of IL-17A occurs locally in inflammatory cells within the human bronchoalveolar space during severe inflammation caused by organic dust.
Spec (whether) Positive_regulation (elevated) of IL-17A associated with inflammation
15) Confidence 0.39 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1166577 Disease Relevance 0.32 Pain Relevance 0.17
Interestingly, this increase in local IL-17A protein is associated not only with an accumulation of neutrophils but also with an accumulation of lymphocytes.
Positive_regulation (increase) of IL-17A in lymphocytes
16) Confidence 0.39 Published 2005 Journal Respir Res Section Body Doc Link PMC1166577 Disease Relevance 0.16 Pain Relevance 0.17
The exposure to organic dust caused more than a forty-fold increase of mRNA for IL-17A in BAL cells.
Positive_regulation (increase) of IL-17A
17) Confidence 0.39 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1166577 Disease Relevance 0.30 Pain Relevance 0.14
Exposure to organic dust increases local IL-17A mRNA and because there is intracellular expression in BAL lymphocytes, this suggests that IL-17A protein can originate from lymphocytes within the human bronchoalveolar space.
Positive_regulation (increases) of IL-17A mRNA in lymphocytes
18) Confidence 0.39 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1166577 Disease Relevance 0.18 Pain Relevance 0.06
The increase in IL-17A mRNA was associated with a substantial increase of the number of BAL neutrophils expressing MMP-9 immunoreactivity.


Positive_regulation (increase) of IL-17A mRNA in neutrophils
19) Confidence 0.39 Published 2005 Journal Respir Res Section Abstract Doc Link PMC1166577 Disease Relevance 0.26 Pain Relevance 0.10
IL-17 has been demonstrated to be elevated in ankylosing spondylitis (AS).
Positive_regulation (elevated) of IL-17 associated with spinal inflammation
20) Confidence 0.28 Published 2009 Journal Clin. Rheumatol. Section Abstract Doc Link 18827961 Disease Relevance 0.20 Pain Relevance 0.20

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