INT153794

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Context Info
Confidence 0.77
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 51
Total Number 60
Disease Relevance 24.99
Pain Relevance 7.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (Ctsk) extracellular space (Ctsk) lysosome (Ctsk)
cytoplasm (Ctsk)
Anatomy Link Frequency
lung 23
osteoclasts 10
tendons 2
epithelial cells 2
fibroblasts 2
Ctsk (Mus musculus)
Pain Link Frequency Relevance Heat
Tendonitis 10 100.00 Very High Very High Very High
metalloproteinase 297 99.80 Very High Very High Very High
fibrosis 784 99.72 Very High Very High Very High
rheumatoid arthritis 371 99.20 Very High Very High Very High
Inflammation 456 96.92 Very High Very High Very High
spinal inflammation 16 96.20 Very High Very High Very High
Arthritis 263 94.56 High High
anesthesia 64 82.72 Quite High
Neuropeptide 8 80.16 Quite High
cytokine 176 79.96 Quite High
Disease Link Frequency Relevance Heat
Targeted Disruption 762 100.00 Very High Very High Very High
Hypercalcemia 112 100.00 Very High Very High Very High
Tendinopathy 10 100.00 Very High Very High Very High
Pulmonary Fibrosis 690 99.92 Very High Very High Very High
Disease 283 99.36 Very High Very High Very High
Rheumatoid Arthritis 371 99.20 Very High Very High Very High
Osteoporosis 420 97.48 Very High Very High Very High
INFLAMMATION 450 96.92 Very High Very High Very High
Low Back Pain 12 96.20 Very High Very High Very High
Fibrosis 153 95.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Effect of bleomycin application on cathepsin K expression in the lungs of mice
Gene_expression (expression) of cathepsin K in lungs
1) Confidence 0.77 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.36 Pain Relevance 0.03
Quantitative measurement of collagen content in the lungs of wild-type mice and cath K tg mice by hydroxyproline assay at various time points post bleomycin challenge showed that transgenic mice exhibiting connatal over-expression of cathepsin K protein in their lungs consistently demonstrated lower total collagen contents in lung parenchymal tissue extracts as compared to wild-type mice with statistically significant differences observed at 2 and 4 weeks post-treatment (Figure 2).


Gene_expression (over) of cathepsin K in lung associated with targeted disruption
2) Confidence 0.77 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.24 Pain Relevance 0
Another study showed that CatK is expressed during the resorption of calcium deposits in calcified tendonitis of the rotator cuff tendons, suggesting CatK as a potential osteoclast marker [20].
Gene_expression (expressed) of CatK in tendons associated with tendonitis
3) Confidence 0.75 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.44 Pain Relevance 0.10
Osteoclasts were shown to synthesize and secrete cathepsin K (CatK) into the extracellular compartment at the attachment site between osteoclasts and the bone surface [19].
Gene_expression (synthesize) of cathepsin K in Osteoclasts
4) Confidence 0.75 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.08 Pain Relevance 0
Therefore, we aimed to characterize the differences between stem and progenitor cells in vitro by analyzing the differentiation capacities of these cells using three approaches: biochemical assays, morphological characterization and genetic analysis involving Opn, CatK and Sca-1 expressions.
Gene_expression (expressions) of CatK in stem
5) Confidence 0.75 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.22 Pain Relevance 0
According to Väänänen et al [32], a high level of CatK expression secreted by osteoclasts in the lacuna is an indicator of the resorption process.
Gene_expression (expression) of CatK in lacuna
6) Confidence 0.75 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.46 Pain Relevance 0.09
Hu et al [30] reported that the expression of CatK is increased during osteoclast differentiation in myeloid progenitor cells.
Gene_expression (expression) of CatK in myeloid progenitor cells
7) Confidence 0.75 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.47 Pain Relevance 0.06
Another recent study showed increased CatK expression during osteoclastogenesis [31].
Gene_expression (expression) of CatK
8) Confidence 0.75 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.47 Pain Relevance 0.07
Osteoclasts were shown to synthesize and secrete cathepsin K (CatK) into the extracellular compartment at the attachment site between osteoclasts and the bone surface [19].
Gene_expression (synthesize) of CatK in Osteoclasts
9) Confidence 0.75 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.08 Pain Relevance 0
Recent investigations have shown that CatK, a lysosomal enzyme is synthesized specifically by cells in the osteoclast lineage [20,21].
Gene_expression (synthesized) of CatK in osteoclast
10) Confidence 0.75 Published 2010 Journal Cancer Cell Int Section Body Doc Link PMC2984396 Disease Relevance 0.09 Pain Relevance 0
For cell-specific detection of cathepsin K protein in BAL cells, lung homogenates and type II alveolar epithelial cells from wild-type or cath K tg mice, cell lysates were prepared in 100 ?
Gene_expression (detection) of cathepsin K in lung
11) Confidence 0.67 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0 Pain Relevance 0
Cath K protein was detected with anti-cathepsin K monoclonal Ab detecting the mature form of cathepsin K (molecular weight, 29 kDa) (Calbiochem, Darmstadt, Germany) using chemiluminescence ECL substrate (Amersham, Buckinghamshire, UK).
Gene_expression (detecting) of cathepsin K
12) Confidence 0.67 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.08 Pain Relevance 0.04
Cath K protein was detected with anti-cathepsin K monoclonal Ab detecting the mature form of cathepsin K (molecular weight, 29 kDa) (Calbiochem, Darmstadt, Germany) using chemiluminescence ECL substrate (Amersham, Buckinghamshire, UK).
Gene_expression (detecting) of cathepsin K
13) Confidence 0.67 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.08 Pain Relevance 0.04
Wild-type and cathepsin K overexpressing (cathepsin K transgenic; cath K tg) mice were challenged intratracheally with bleomycin and sacrificed at 1, 2, 3 and 4 weeks post-treatment followed by determination of lung fibrosis by estimating lung collagen content, lung histopathology, leukocytic infiltrates and lung function.
Gene_expression (overexpressing) of cathepsin K in lung associated with targeted disruption, fibrosis and pulmonary fibrosis
14) Confidence 0.60 Published 2008 Journal Respir Res Section Abstract Doc Link PMC2490691 Disease Relevance 0.85 Pain Relevance 0.22
Characterization of cathepsin K overexpression in the lungs of mice
Gene_expression (overexpression) of cathepsin K in lungs
15) Confidence 0.60 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.16 Pain Relevance 0.08
We here tested the hypothesis that over-expression of cathepsin K in the lungs of mice is protective in bleomycin-induced pulmonary fibrosis.


Gene_expression (expression) of cathepsin K in lungs associated with fibrosis and pulmonary fibrosis
16) Confidence 0.60 Published 2008 Journal Respir Res Section Abstract Doc Link PMC2490691 Disease Relevance 0.79 Pain Relevance 0.22
Cathepsin K is expressed in bone osteclasts and chondroclasts, but also in epithelioid cells and multinucleated giant cells in lung granulomatous lesions, whereas it is largely absent in resident alveolar macrophages of the lung under baseline conditions [6].
Neg (absent) Gene_expression (expressed) of Cathepsin K in chondroclasts
17) Confidence 0.60 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 1.02 Pain Relevance 0.18
Based on these observations, we hypothesized that over-expression of cathepsin K in the lungs of mice would ameliorate lung fibrosis and lung resistance in mice challenged with bleomycin.
Gene_expression (-) of cathepsin K in lung associated with fibrosis and pulmonary fibrosis
18) Confidence 0.60 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.61 Pain Relevance 0.11
Together, this study shows that overexpression of cathepsin K does not adversely affect normal lung architecture in mice but at least partially protects against peak lung fibrotic responses and lung resistance upon bleomycin challenge.
Gene_expression (overexpression) of cathepsin K in lung associated with fibrosis
19) Confidence 0.60 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.61 Pain Relevance 0.13
In the current study, cathepsin K was not detected in freshly isolated type II alveolar epithelial cells, as opposed to bronchial epithelial cells previously reported to express cathepsin K [7].
Gene_expression (express) of cathepsin K in epithelial cells
20) Confidence 0.60 Published 2008 Journal Respir Res Section Body Doc Link PMC2490691 Disease Relevance 0.36 Pain Relevance 0.07

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