INT153800

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.49
First Reported 2003
Last Reported 2010
Negated 2
Speculated 0
Reported most in Body
Documents 18
Total Number 18
Disease Relevance 16.16
Pain Relevance 1.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (PARP1) nuclear envelope (PARP1) transferase activity, transferring glycosyl groups (PARP1)
intracellular (PARP1) DNA binding (PARP1) nucleolus (PARP1)
Anatomy Link Frequency
cleavage 22
MCF-7 3
macrophages 2
poly 2
HL-60 1
PARP1 (Homo sapiens)
Pain Link Frequency Relevance Heat
aspirin 11 99.50 Very High Very High Very High
qutenza 7 99.12 Very High Very High Very High
dexamethasone 51 95.12 Very High Very High Very High
Taxol 2 85.36 High High
cINOD 50 83.96 Quite High
Inflammatory response 3 78.00 Quite High
agonist 20 72.40 Quite High
Arthritis 2 67.16 Quite High
Rheumatism 2 66.72 Quite High
Neuritis 2 66.24 Quite High
Disease Link Frequency Relevance Heat
Death 183 100.00 Very High Very High Very High
Colon Cancer 161 99.84 Very High Very High Very High
Apoptosis 880 99.48 Very High Very High Very High
Coronary Artery Disease 3 98.84 Very High Very High Very High
Pancreatic Cancer 7 98.52 Very High Very High Very High
Breast Cancer 96 97.68 Very High Very High Very High
Skin Cancer 26 95.64 Very High Very High Very High
Cancer 652 94.24 High High
Stress 85 83.04 Quite High
Myocardial Infarction 2 82.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
ASA and NaS at 1 mM did not induce PARP cleavage or caspase-3 and at 5 mM, ASA but not NaS increased apoptosis.
Neg (not) Positive_regulation (induce) of Neg (not) Protein_catabolism (cleavage) of PARP in cleavage associated with aspirin and apoptosis
1) Confidence 0.49 Published 2008 Journal Mol. Pharmacol. Section Abstract Doc Link 18678619 Disease Relevance 0.67 Pain Relevance 0.66
In HL-60 and MCF-7 cells this extract was a very strong inducer of cell death activating caspase-3 followed by PARP signature type cleavage.
Positive_regulation (inducer) of Protein_catabolism (cleavage) of PARP in MCF-7 associated with death
2) Confidence 0.35 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19287970 Disease Relevance 1.20 Pain Relevance 0.25
These results are in agreement with previous reports in that tolfenamic acid induces PARP cleavage in colorectal cancer cells [19] and pancreatic cancer cells [4].
Positive_regulation (induces) of Protein_catabolism (cleavage) of PARP in cleavage associated with pancreatic cancer and colon cancer
3) Confidence 0.34 Published 2010 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2901767 Disease Relevance 0.82 Pain Relevance 0.07
In contrast, cell-cycle regulator p27(KIP1), caspase activity as well as poly-ADP ribose polymerase (PARP) cleavage were increased.
Positive_regulation (increased) of Protein_catabolism (cleavage) of PARP in cleavage
4) Confidence 0.26 Published 2010 Journal Oncogene Section Abstract Doc Link 19855437 Disease Relevance 0.89 Pain Relevance 0.45
These latter two agents caused no increase in the cleavage of PARP.
Neg (no) Positive_regulation (increase) of Protein_catabolism (cleavage) of PARP in cleavage
5) Confidence 0.25 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0 Pain Relevance 0.06
It enhanced activation of caspase 8 and subsequent cleavage of PARP and ?
Positive_regulation (enhanced) of Protein_catabolism (cleavage) of PARP in cleavage
6) Confidence 0.20 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 0.98 Pain Relevance 0
U0126 induced the release of cytochrome c and increased the cleavage of caspase-3, caspase-7, and poly ADP-ribose polymerase (PARP).
Positive_regulation (increased) of Protein_catabolism (cleavage) of poly ADP-ribose polymerase in poly
7) Confidence 0.20 Published 2003 Journal BMC Gastroenterol Section Abstract Doc Link PMC317301 Disease Relevance 0.87 Pain Relevance 0
ELISA detection of the apoptotic DNA fragmentation at 24 hours (Figure 2b) as well as western blot analysis for cleaved PARP at 48 hours of treatment (Figure 2c) indicated increased caspase-mediated apoptosis at 50 ?
Positive_regulation (increased) of Protein_catabolism (cleaved) of PARP associated with apoptosis
8) Confidence 0.16 Published 2007 Journal Breast Cancer Res Section Body Doc Link PMC2246173 Disease Relevance 0.79 Pain Relevance 0
In addition, curcumin-induced apoptosis was also associated with the activation of caspase-3 and caspase-9, and the degradation of PARP.
Positive_regulation (activation) of Protein_catabolism (degradation) of PARP associated with apoptosis
9) Confidence 0.15 Published 2010 Journal International Journal of Cell Biology Section Body Doc Link PMC2841246 Disease Relevance 1.08 Pain Relevance 0
It enhanced activation of caspase 8 and subsequent cleavage of PARP and ?
Positive_regulation (activation) of Protein_catabolism (cleavage) of PARP in cleavage
10) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 0.98 Pain Relevance 0
Biochemical analysis confirmed that while macrophages inhibited TRAIL-induced activation of caspase 8 and caspase-9 and cleavage of PARP and ?
Positive_regulation (activation) of Protein_catabolism (cleavage) of PARP in macrophages
11) Confidence 0.15 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2908545 Disease Relevance 1.15 Pain Relevance 0
This sensitization may be due to restored apoptotic pathway, as indicated by enhanced cleavage of pro-caspase 10 and PARP and increased DNA fragmentation.
Positive_regulation (enhanced) of Protein_catabolism (cleavage) of PARP in cleavage associated with apoptosis
12) Confidence 0.13 Published 2010 Journal Journal of Cancer Section Body Doc Link PMC2938072 Disease Relevance 1.86 Pain Relevance 0
In HL-60 and MCF-7 cells this extract was a very strong inducer of cell death activating caspase-3 followed by PARP signature type cleavage.
Positive_regulation (inducer) of in HL-60 Protein_catabolism (cleavage) of PARP in MCF-7 associated with death
13) Confidence 0.12 Published 2009 Journal Int. J. Oncol. Section Abstract Doc Link 19287970 Disease Relevance 1.20 Pain Relevance 0.25
Western blot analysis revealed that NaAsO2 exposure caused the degradation of 116 kDa PARP to the characteristic 84 kDa PARP fragment (figure 3F).
Positive_regulation (caused) of Protein_catabolism (degradation) of PARP
14) Confidence 0.06 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.57 Pain Relevance 0
Traslocation of cytochrome C to the cytoplasm is crucial to the activation of the initiator caspase-9 and the executioner caspases-3 and -7, followed by cleavage of PARP and activation of Caspase-activated DNase (CAD) and DNA fragmentation.
Positive_regulation (activation) of Protein_catabolism (cleavage) of PARP in cleavage associated with coronary artery disease
15) Confidence 0.06 Published 2006 Journal BMC Neurosci Section Body Doc Link PMC1775042 Disease Relevance 0.75 Pain Relevance 0
However, taurine treatment could inhibit this NaAsO2-induced cleavage of PARP.


Positive_regulation (induced) of Protein_catabolism (cleavage) of PARP in cleavage
16) Confidence 0.04 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2935368 Disease Relevance 0.76 Pain Relevance 0
Results of the current study revealed increased caspase- 3 activation and PARP cleavage in CCl4 treated rats in comparison with controls.
Positive_regulation (activation) of Protein_catabolism (cleavage) of PARP in cleavage
17) Confidence 0.03 Published 2010 Journal BMC Pharmacol Section Body Doc Link PMC2967507 Disease Relevance 0.53 Pain Relevance 0
Vanadate also prevented GC-induced poly-ADP-ribose polymerase cleavage.
Positive_regulation (induced) of Protein_catabolism (cleavage) of poly-ADP-ribose polymerase in cleavage
18) Confidence 0.03 Published 2007 Journal The Journal of Endocrinology Section Abstract Doc Link PMC2173947 Disease Relevance 1.04 Pain Relevance 0.16

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox