INT153814

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Context Info
Confidence 0.65
First Reported 2005
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 19
Total Number 23
Disease Relevance 18.25
Pain Relevance 7.68

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (LPA) transport (LPA) small molecule metabolic process (LPA)
extracellular region (LPA) lipid metabolic process (LPA)
Anatomy Link Frequency
blood platelets 3
plasma 1
brainstem 1
nociceptors 1
midbrain 1
LPA (Homo sapiens)
Pain Link Frequency Relevance Heat
Herpes zoster virus 1 100.00 Very High Very High Very High
midbrain 16 99.68 Very High Very High Very High
Inflammation 93 99.52 Very High Very High Very High
substance P 21 99.28 Very High Very High Very High
medulla 17 99.16 Very High Very High Very High
Cancer pain 101 98.68 Very High Very High Very High
chemokine 10 98.64 Very High Very High Very High
bradykinin 15 98.20 Very High Very High Very High
tolerance 11 98.12 Very High Very High Very High
cytokine 28 98.08 Very High Very High Very High
Disease Link Frequency Relevance Heat
Cancer 183 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 57 100.00 Very High Very High Very High
Stress 46 100.00 Very High Very High Very High
Infection 9 100.00 Very High Very High Very High
Lichen 4 100.00 Very High Very High Very High
Cytomegalovirus Infection 2 100.00 Very High Very High Very High
Chlamydia Infection 2 100.00 Very High Very High Very High
Herpes Zoster 1 100.00 Very High Very High Very High
Injury 15 99.76 Very High Very High Very High
Atherosclerotic Plaque 7 99.60 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Lp(a) was measured by an immunonephelometric assay using a latex Lp(a) reagent composed of polystyrene particles coated with a rabbit antihuman Lp(a) ?
Localization (measured) of Lp
1) Confidence 0.65 Published 2010 Journal Korean Circulation Journal Section Body Doc Link PMC2978291 Disease Relevance 0.63 Pain Relevance 0
Thirdly, certain diseases may influence activated LPA release, including inflammatory processes, hypercholesterolemia or diabetes mellitus.
Localization (release) of LPA associated with inflammation, diabetes mellitus, hyperlipidemia and disease
2) Confidence 0.64 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996775 Disease Relevance 1.39 Pain Relevance 0.05
Although the etiology of LP is idiopathic, oral lichenoid reactions may be caused by medications or exogenous agents such as cinnamates and other flavorings.
Localization (etiology) of LP associated with lichen
3) Confidence 0.62 Published 2010 Journal Dermatol Ther Section Abstract Doc Link 20597944 Disease Relevance 0.98 Pain Relevance 0.13
LPA is also abundant in human atherosclerotic plaques, where it is thought to be derived, at least in part, from mild oxidation of low density lipoproteins [10].
Localization (abundant) of LPA in plaques associated with atherosclerotic plaque
4) Confidence 0.60 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996775 Disease Relevance 1.50 Pain Relevance 0
AIMS: Lysophosphatidic acid (LPA) is released from injured tissue and cancer cells and is involved in the induction of neuropathic pain.
Localization (released) of LPA associated with cancer and neuropathic pain
5) Confidence 0.59 Published 2010 Journal Life Sci. Section Abstract Doc Link 20553953 Disease Relevance 0.35 Pain Relevance 0.33
M forskolin, and varying concentrations of LPA was added to the cells for 20 minutes at 37°C.
Localization (concentrations) of LPA
6) Confidence 0.39 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0.09 Pain Relevance 0
The latter peak was consistently observed in both LPA and S1P treated cells, but did not meet statistical criteria for significance in LPA treated cells.


Localization (observed) of LPA
7) Confidence 0.39 Published 2008 Journal BMC Neurosci Section Body Doc Link PMC2621239 Disease Relevance 0 Pain Relevance 0
Here we show that FPP and LPA are significantly more abundant in the midbrain and brainstem.
Localization (abundant) of LPA in midbrain associated with medulla and midbrain
8) Confidence 0.12 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996792 Disease Relevance 1.19 Pain Relevance 1.39
Therefore, interpretation of Lp(a) should be cautiously exercised among diabetic subjects.


Localization (interpretation) of Lp associated with diabetes mellitus
9) Confidence 0.12 Published 2007 Journal Lipids Health Dis Section Body Doc Link PMC2216007 Disease Relevance 0.71 Pain Relevance 0
However, LPA-induced ATP release was also blocked by the Galpha(q/11) AS-ODN, but not by pertussis toxin.
Localization (release) of LPA associated with bordatella infection
10) Confidence 0.10 Published 2008 Journal J. Neurochem. Section Abstract Doc Link 18680554 Disease Relevance 0.17 Pain Relevance 0.08
LPA is released from activated platelets and this stimulates other platelets to activate aggregation processes [76,77].
Localization (released) of LPA in platelets
11) Confidence 0.08 Published 2005 Journal BMC Cell Biol Section Body Doc Link PMC1090567 Disease Relevance 0 Pain Relevance 0
The classical cardiovascular risk factors (hypercholesterolemia, hypertension, smoking, diabetes, sedentary, etc.) and the so called new risk factors like hiperhomocysteinemia, lipoprotein Lp(a), infections by Chlamydia pneumoniae, Helicobacter Pilorae, Cytomegalovirus, herpes zoster virus or bacteroides gingivalis, all have a common factor which is a state of oxidative stress that directly or through heating proteins (HSP-60), stimulate NF-kB replication that leads to the production of proatherogenic cytokines like TNF-?
Localization (replication) of Lp associated with stress, pressure and volume under development, nicotine addiction, diabetes mellitus, cytomegalovirus infection, chlamydia infection, infection, cytokine, herpes zoster virus and hyperlipidemia
12) Confidence 0.07 Published 2006 Journal Cardiovasc Diabetol Section Body Doc Link PMC1434727 Disease Relevance 1.77 Pain Relevance 0.41
The second step is an attack by water on the covalent enzyme intermediate, and this releases the final product, LPA.
Localization (releases) of LPA
13) Confidence 0.05 Published 2009 Journal Lipids Health Dis Section Body Doc Link PMC2649126 Disease Relevance 0.08 Pain Relevance 0
In spite of its presence in plasma along with abundant putative substrate LPC, the product LPA is found in plasma at unexpectedly low concentrations.
Localization (found) of LPA in plasma
14) Confidence 0.05 Published 2009 Journal Lipids Health Dis Section Abstract Doc Link PMC2649126 Disease Relevance 0.17 Pain Relevance 0
ApoB100 is the major apolipoprotein found in LDL, intermediate-density lipoprotein (IDL), and very low-density lipoprotein (VLDL), and it is the primary ligand for the LDL receptor.
Localization (found) of apolipoprotein associated with disorder of lipid metabolism
15) Confidence 0.05 Published 2009 Journal Vascular Health and Risk Management Section Body Doc Link PMC2742703 Disease Relevance 0.73 Pain Relevance 0
Here we show that FPP and LPA are significantly more abundant in the midbrain and brainstem.
Localization (abundant) of LPA in brainstem associated with medulla and midbrain
16) Confidence 0.04 Published 2010 Journal International Journal of Molecular Sciences Section Body Doc Link PMC2996792 Disease Relevance 1.19 Pain Relevance 1.39
Released by cancer cells and blood platelets, LPA not only promotes cancer cell proliferation but also contributes to the induction of bone cancer pain by enhancing TRPV1 activity in nociceptors.
Localization (Released) of LPA in nociceptors associated with cancer pain, cancer, nociceptor and bone cancer
17) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 1.11 Pain Relevance 0.86
Released by activated blood platelets [8], LPA promotes progression of bone metastases by inducing secretion of tumor-derived cytokine (IL-6 and IL-8) in breast and ovarian cancer cells [9,10].
Localization (Released) of LPA in blood platelets associated with cancer, ovarian cancer, metastasis and cytokine
18) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 1.79 Pain Relevance 0.54
It has been demonstrated that lysophosphatidic acid (LPA) released from injury tissue and transient receptor potential vanilloid 1 (TRPV1) receptor are implicated in the induction of chronic pain.
Localization (released) of LPA associated with lasting pain and injury
19) Confidence 0.03 Published 2010 Journal Mol Pain Section Abstract Doc Link PMC3004845 Disease Relevance 0.85 Pain Relevance 0.53
Understanding how cancer cells secrete and recruit cells to release LPA is significant for treatment of cancer pain.
Localization (release) of LPA associated with cancer pain and cancer
20) Confidence 0.03 Published 2010 Journal Mol Pain Section Body Doc Link PMC3004845 Disease Relevance 1.16 Pain Relevance 0.72

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