INT153865

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.51
First Reported 2008
Last Reported 2008
Negated 0
Speculated 1
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.56
Pain Relevance 2.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
liver 1
brain 1
cerebellum 1
hippocampus 1
frontal cortex 1
Cyp2d (Mus musculus)
Pain Link Frequency Relevance Heat
Versed 64 100.00 Very High Very High Very High
Nicotine 32 99.16 Very High Very High Very High
Hippocampus 4 98.32 Very High Very High Very High
medulla 4 94.64 High High
Substantia nigra 4 92.08 High High
Catecholamine 4 56.24 Quite High
opiate 4 54.28 Quite High
antidepressant 4 53.36 Quite High
Paracetamol 6 49.12 Quite Low
Bioavailability 14 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 4 97.68 Very High Very High Very High
Nicotine Addiction 8 92.96 High High
Disease 4 90.88 High High
Parkinson's Disease 4 60.60 Quite High
Targeted Disruption 4 5.00 Very Low Very Low Very Low
Herpes Simplex Virus 2 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These results suggest that monkey brain expresses CYP2D, which is induced in specific cells and brain regions upon chronic nicotine treatment.
Gene_expression (expresses) of CYP2D in brain associated with nicotine
1) Confidence 0.51 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18687346 Disease Relevance 0.38 Pain Relevance 0.45
Immunocytochemistry revealed that the expression of CYP2D in both saline- and nicotine-treated monkeys is cell-specific particularly in the cerebellum, frontal cortex and hippocampus.
Gene_expression (expression) of CYP2D in frontal cortex associated with nicotine, urological neuroanatomy and hippocampus
2) Confidence 0.51 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18687346 Disease Relevance 0.39 Pain Relevance 0.57
The NADH-mediated in vitro turnovers of the probe drugs
chlorzoxazone (Cyp2e1), metoprolol (Cyp2d), midazolam (Cyp2c, Cyp3a),
tolbutamide (Cyp2c), and phenacetin (Cyp1a)
(37–41)
were also examined with liver microsomes from both HBN and wild-type mice.

Spec (examined) Gene_expression (examined) of Cyp2d in liver associated with versed
3) Confidence 0.48 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2581580 Disease Relevance 0 Pain Relevance 0.12
A slight
reduction in Cyp2d expression was also observed. 
Gene_expression (expression) of Cyp2d
4) Confidence 0.43 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2581580 Disease Relevance 0 Pain Relevance 0
Immunocytochemistry revealed that the expression of CYP2D in both saline- and nicotine-treated monkeys is cell-specific particularly in the cerebellum, frontal cortex and hippocampus.
Gene_expression (expression) of CYP2D in hippocampus associated with nicotine, urological neuroanatomy and hippocampus
5) Confidence 0.17 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18687346 Disease Relevance 0.39 Pain Relevance 0.57
Immunocytochemistry revealed that the expression of CYP2D in both saline- and nicotine-treated monkeys is cell-specific particularly in the cerebellum, frontal cortex and hippocampus.
Gene_expression (expression) of CYP2D in cerebellum associated with nicotine, urological neuroanatomy and hippocampus
6) Confidence 0.17 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18687346 Disease Relevance 0.39 Pain Relevance 0.57

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox