INT153865

Context Info Confidence 0.51 First Reported 2008 Last Reported 2008 Negated 0 Speculated 1 Reported most in Abstract Documents 5 Total Number 6 Disease Relevance 1.56 Pain Relevance 2.28

Anatomy Link Frequency liver 1 brain 1 cerebellum 1 hippocampus 1 frontal cortex 1 Cyp2d (Mus musculus)

Pain Link Frequency Relevance Heat Versed 64 100.00 Nicotine 32 99.16 Hippocampus 4 98.32 medulla 4 94.64 Substantia nigra 4 92.08 Catecholamine 4 56.24 opiate 4 54.28 antidepressant 4 53.36 Paracetamol 6 49.12 Bioavailability 14 5.00

Disease Link Frequency Relevance Heat Urological Neuroanatomy 4 97.68 Nicotine Addiction 8 92.96 Disease 4 90.88 Parkinson's Disease 4 60.60 Targeted Disruption 4 5.00 Herpes Simplex Virus 2 5.00 Toxicity 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

These results suggest that monkey brain expresses CYP2D, which is induced in specific cells and brain regions upon chronic nicotine treatment.

Gene_expression (expresses) of CYP2D in brain associated with nicotine

1) Confidence 0.51 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18687346 Disease Relevance 0.38 Pain Relevance 0.45

Immunocytochemistry revealed that the expression of CYP2D in both saline- and nicotine-treated monkeys is cell-specific particularly in the cerebellum, frontal cortex and hippocampus.

Gene_expression (expression) of CYP2D in frontal cortex associated with nicotine, urological neuroanatomy and hippocampus

2) Confidence 0.51 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18687346 Disease Relevance 0.39 Pain Relevance 0.57

The NADH-mediated in vitro turnovers of the probe drugs chlorzoxazone (Cyp2e1), metoprolol (Cyp2d), midazolam (Cyp2c, Cyp3a), tolbutamide (Cyp2c), and phenacetin (Cyp1a) (37–41) were also examined with liver microsomes from both HBN and wild-type mice.

Spec (examined) Gene_expression (examined) of Cyp2d in liver associated with versed

3) Confidence 0.48 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2581580 Disease Relevance 0 Pain Relevance 0.12

A slight reduction in Cyp2d expression was also observed.

Gene_expression (expression) of Cyp2d

4) Confidence 0.43 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2581580 Disease Relevance 0 Pain Relevance 0

Immunocytochemistry revealed that the expression of CYP2D in both saline- and nicotine-treated monkeys is cell-specific particularly in the cerebellum, frontal cortex and hippocampus.

Gene_expression (expression) of CYP2D in hippocampus associated with nicotine, urological neuroanatomy and hippocampus

5) Confidence 0.17 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18687346 Disease Relevance 0.39 Pain Relevance 0.57

Immunocytochemistry revealed that the expression of CYP2D in both saline- and nicotine-treated monkeys is cell-specific particularly in the cerebellum, frontal cortex and hippocampus.

Gene_expression (expression) of CYP2D in cerebellum associated with nicotine, urological neuroanatomy and hippocampus

6) Confidence 0.17 Published 2008 Journal Neuropharmacology Section Abstract Doc Link 18687346 Disease Relevance 0.39 Pain Relevance 0.57

General Comments

This test has worked.