INT1539

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Context Info
Confidence 0.69
First Reported 1978
Last Reported 2010
Negated 1
Speculated 1
Reported most in Abstract
Documents 22
Total Number 23
Disease Relevance 9.42
Pain Relevance 4.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (MSMB) extracellular region (MSMB) nucleus (MSMB)
molecular_function (MSMB) biological_process (MSMB)
Anatomy Link Frequency
PSP 7
PSp 6
monocyte 1
anterior 1
uterine cervix 1
MSMB (Homo sapiens)
Pain Link Frequency Relevance Heat
tetrodotoxin 187 100.00 Very High Very High Very High
Dismenorea 2 99.88 Very High Very High Very High
lidocaine 12 99.16 Very High Very High Very High
Pain 11 97.76 Very High Very High Very High
Chronic pancreatitis 7 97.64 Very High Very High Very High
aspirin 13 97.52 Very High Very High Very High
anesthesia 15 88.56 High High
repetitive firing 1 77.76 Quite High
Potency 6 77.36 Quite High
amygdala 4 75.60 Quite High
Disease Link Frequency Relevance Heat
Poisoning 44 100.00 Very High Very High Very High
Dysmenorrhea 2 99.88 Very High Very High Very High
Chronic Renal Failure 4 99.72 Very High Very High Very High
Pancreatitis 18 99.56 Very High Very High Very High
Renal Disease 1 98.36 Very High Very High Very High
Shock 16 98.12 Very High Very High Very High
Cataract 1 98.08 Very High Very High Very High
Obesity 7 97.52 Very High Very High Very High
Body Weight Changes 2 97.08 Very High Very High Very High
Body Weight 2 96.40 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Recent clinical investigations have further demonstrated elevation of PSP in the serum and urine of patients with renal disease as well as pancreatic disease.
Positive_regulation (elevation) of PSP in urine associated with pancreatitis and renal disease
1) Confidence 0.69 Published 1994 Journal Nagoya J Med Sci Section Abstract Doc Link 7898566 Disease Relevance 0.47 Pain Relevance 0.28
These findings indicate that plasma beta-EP is elevated in the early phase of fasting, while not directly being associated with body weight changes.
Positive_regulation (elevated) of plasma beta-EP in plasma associated with body weight changes
2) Confidence 0.62 Published 1990 Journal Horm. Res. Section Abstract Doc Link 2289782 Disease Relevance 0.34 Pain Relevance 0.05
Increased serum PSP levels in acute pancreatitis and chronic renal failure suggest that serum PSP levels reflect reflex from pancreatic secretion, release from damaged pancreatic acinar cells, or retention in circulation, and can be useful for diagnosis of acute pancreatitis, but not chronic calcified pancreatitis.
Positive_regulation (Increased) of serum PSP in PSP associated with chronic renal failure and pancreatitis
3) Confidence 0.60 Published 1993 Journal Int. J. Pancreatol. Section Abstract Doc Link 8501356 Disease Relevance 1.40 Pain Relevance 0.17
Group B had lower levels of plasma beta-EP on the 5th day of fasting than group A (p less than 0.05).
Positive_regulation (levels) of plasma beta-EP in plasma
4) Confidence 0.45 Published 1990 Journal Horm. Res. Section Abstract Doc Link 2289782 Disease Relevance 0.30 Pain Relevance 0.07
Increased serum PSP levels in acute pancreatitis and chronic renal failure suggest that serum PSP levels reflect reflex from pancreatic secretion, release from damaged pancreatic acinar cells, or retention in circulation, and can be useful for diagnosis of acute pancreatitis, but not chronic calcified pancreatitis.
Positive_regulation (useful) of serum PSP in PSP associated with chronic renal failure and pancreatitis
5) Confidence 0.43 Published 1993 Journal Int. J. Pancreatol. Section Abstract Doc Link 8501356 Disease Relevance 1.38 Pain Relevance 0.16
Several mismatches to the mrtA gene sequence of Msp.stadtmanae were evident with the mcrA primer set and phylogenetic analysis and tree construction illustrates that although the mrtA gene of Msp. stadtmanae encodes an enzyme of the same function and inhabits the same niche it is phylogenetically distinct from mcrA gene sequences of Mbb. smithii and related clones (see Figure 2).
Positive_regulation (sequence) of Msp
6) Confidence 0.43 Published 2008 Journal BMC Microbiol Section Body Doc Link PMC2408590 Disease Relevance 0.57 Pain Relevance 0
The PSP, defined as pressure in the posterior segment when the anterior segment is at atmospheric pressure, is the main factor affecting surgical conditions, a rise in PSP possibly resulting in typical complications of cataract surgery but having beneficial effects in corneal grafts for example.
Spec (possibly) Positive_regulation (rise) of PSP in anterior associated with cataract
7) Confidence 0.35 Published 1983 Journal J Fr Ophtalmol Section Abstract Doc Link 6630889 Disease Relevance 0.10 Pain Relevance 0.40
At the 8th estrous cycle after operation, PSP was induced by mechanical stimulation of the uterine cervix.
Positive_regulation (induced) of PSP in uterine cervix
8) Confidence 0.30 Published 1998 Journal Endocr. J. Section Abstract Doc Link 9790273 Disease Relevance 0 Pain Relevance 0.23
Pinealectomy or melatonin installation did not disturb the estrous cyclicity or the induction of PSP.
Positive_regulation (induction) of PSP in PSP
9) Confidence 0.26 Published 1998 Journal Endocr. J. Section Abstract Doc Link 9790273 Disease Relevance 0 Pain Relevance 0.22
Dextran 40 and dextran 70 infusion increased QXe, PSp, and PmO2 to or above control levels, PSp to 60%, and QXe to 40% of the control values.
Positive_regulation (increased) of PSp in PSp
10) Confidence 0.23 Published 1980 Journal Circ. Shock Section Abstract Doc Link 7226434 Disease Relevance 0.41 Pain Relevance 0
Dextran 40 and dextran 70 infusion increased QXe, PSp, and PmO2 to or above control levels, PSp to 60%, and QXe to 40% of the control values.
Positive_regulation (increased) of PSp in PSp
11) Confidence 0.22 Published 1980 Journal Circ. Shock Section Abstract Doc Link 7226434 Disease Relevance 0.41 Pain Relevance 0
Only dextran 40 and dextran 70 increased both QXe and PSp significantly in relation to no -fluid infusion.
Positive_regulation (increased) of PSp in PSp
12) Confidence 0.22 Published 1980 Journal Circ. Shock Section Abstract Doc Link 7226434 Disease Relevance 0.35 Pain Relevance 0
These phenomena were not observed in non-toxic fish, suggesting the presence of a specific mechanism in the pufferfish liver or skin whereby the fish selectively and/or actively accumulate TTX/PSP.
Positive_regulation (accumulate) of PSP in skin associated with tetrodotoxin and poisoning
13) Confidence 0.05 Published 2008 Journal Marine Drugs Section Body Doc Link PMC2525488 Disease Relevance 0.40 Pain Relevance 1.13
The selection of PSP targets is based largely on circumstantial evidence of their contribution to known clinical ADRs, inferred from findings in clinical trials, animal experiments, and molecular studies going back more than forty years.
Positive_regulation (selection) of PSP in PSP associated with adverse drug reaction
14) Confidence 0.05 Published 2007 Journal ChemMedChem Section Abstract Doc Link 17477341 Disease Relevance 0.49 Pain Relevance 0
Methylation-specific polymerase chain reaction (PCR), i.e., MSP, was performed for CDH1 gene promoter.
Positive_regulation (performed) of MSP
15) Confidence 0.04 Published 2010 Journal Dig. Dis. Sci. Section Abstract Doc Link 19184424 Disease Relevance 0.80 Pain Relevance 0.46
None of the lidocaine infusions into the mPOA prevented the establishment of PSP, and neither verapamil infusions into the mAMYG nor the shorter-term neural block (i.e. single or double lidocaine infusions) of the mAMYG prevented mating-induced PSP.
Neg (nor) Positive_regulation (induced) of PSP in PSP associated with lidocaine
16) Confidence 0.03 Published 1996 Journal J. Neuroendocrinol. Section Abstract Doc Link 8861281 Disease Relevance 0.11 Pain Relevance 0.64
In the rat, vaginocervical stimulation (VCS) received during mating is required for the subsequent expression of 10-12 days of twice-daily prolactin surges that are necessary for pregnancy or pseudopregnancy (PSP).
Positive_regulation (necessary) of PSP in PSP
17) Confidence 0.02 Published 1996 Journal J. Neuroendocrinol. Section Abstract Doc Link 8861281 Disease Relevance 0.15 Pain Relevance 0.15
Plasma beta human chorionic gonadotropin (hCG) levels were relatively constant during RU 486 treatment, but dropped dramatically 2-4 days later.
Positive_regulation (constant) of Plasma beta in Plasma
18) Confidence 0.02 Published 1987 Journal Contraception Section Abstract Doc Link 2445524 Disease Relevance 0.93 Pain Relevance 0.33
Perfusion with A23187, caffeine or DBc-AMP increased the H-phase of the PSP.
Positive_regulation (increased) of PSP in PSP
19) Confidence 0.02 Published 1978 Journal J. Neurobiol. Section Abstract Doc Link 213535 Disease Relevance 0.13 Pain Relevance 0.31
Four of these molecules are the targets of antibodies that inhibit red blood cell invasion, namely merozoite surface protein 1 (MSP1) [10], MSP2 [11], apical membrane antigen 1 (AMA1) [12,13], and ring-infected erythrocyte surface antigen (RESA) [14], whereas MSP3 is targeted by cytophilic antibodies inhibiting intra-erythrocytic parasite growth in a monocyte-dependent manner [15].


Positive_regulation (targeted) of MSP3 in monocyte
20) Confidence 0.02 Published 2007 Journal PLoS Medicine Section Body Doc Link PMC2071934 Disease Relevance 0.31 Pain Relevance 0

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