INT15390

Context Info Confidence 0.70 First Reported 1990 Last Reported 2011 Negated 4 Speculated 2 Reported most in Abstract Documents 64 Total Number 66 Disease Relevance 47.36 Pain Relevance 23.80

extracellular space (Edn1) extracellular region (Edn1) cell-cell signaling (Edn1) cytoplasm (Edn1)

Anatomy Link Frequency plasma 18 endothelial cells 5 heart 2 medulla 2 liver 2 Edn1 (Mus musculus)

Pain Link Frequency Relevance Heat Spontaneous pain 5 99.96 cINOD 2 99.96 Sciatic nerve 4 99.84 substance P 5 99.80 algogenic 1 99.76 midbrain 6 99.16 pulpitis 2 98.96 medulla 6 98.76 Antinociceptive 6 98.70 Pain 194 98.56

Disease Link Frequency Relevance Heat Reprotox - General 1 46 100.00 Bone Disease 7 100.00 Hypoxia 20 99.98 Disease 100 99.80 Myocardial Infarction 98 99.76 Disorders Of Creatine Metabolism 2 99.76 INFLAMMATION 134 99.68 Metabolic Syndrome 13 99.60 Pain 177 99.48 Diabetes Mellitus 60 99.24

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Furthermore, the antinociceptive effect of ET-1 in diabetic mice was decreased when the doses of ET-1 were increased.

Positive_regulation (increased) of ET-1 associated with diabetes mellitus and antinociceptive

1) Confidence 0.70 Published 1993 Journal Res. Commun. Chem. Pathol. Pharmacol. Section Abstract Doc Link 8451542 Disease Relevance 0.72 Pain Relevance 0.49

We found that ET-1 was increased in the hypothalamus while no significant increase was observed in the midbrain, medulla and spinal cord.

Positive_regulation (increased) of ET-1 in medulla associated with medulla, midbrain and spinal cord

2) Confidence 0.70 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664691 Disease Relevance 1.60 Pain Relevance 1.43

Substance P (SP) and endothelin 1 (ET 1) determined by enzyme immuno assay (EIA) were increased in sciatic nerves from NEP ko mice after CCI.

Positive_regulation (increased) of ET 1 in sciatic nerves associated with eae, sciatic nerve and substance p

3) Confidence 0.63 Published 2009 Journal Neurobiol. Dis. Section Abstract Doc Link 19084065 Disease Relevance 1.76 Pain Relevance 1.10

Substance P (SP) and endothelin 1 (ET 1) determined by enzyme immuno assay (EIA) were increased in sciatic nerves from NEP ko mice after CCI.

Positive_regulation (increased) of endothelin 1 in sciatic nerves associated with eae, sciatic nerve and substance p

4) Confidence 0.63 Published 2009 Journal Neurobiol. Dis. Section Abstract Doc Link 19084065 Disease Relevance 1.76 Pain Relevance 1.10

Attenuated CFVR in the symptomatic hypertensive patients was associated with endothelial dysfunction, which results in elevated plasma ET-1 levels.

Positive_regulation (elevated) of ET-1 in plasma associated with hypertension

5) Confidence 0.62 Published 2005 Journal Hypertens. Res. Section Abstract Doc Link 16555580 Disease Relevance 0.65 Pain Relevance 0.31

In addition, elevated plasma endothelin-1 (ET-1) levels have been reported to be associated with microvascular angina.

Positive_regulation (elevated) of ET-1 in plasma associated with angina and microvascular angina

6) Confidence 0.62 Published 2005 Journal Hypertens. Res. Section Abstract Doc Link 16555580 Disease Relevance 1.06 Pain Relevance 0.53

Attenuated CFVR in the symptomatic hypertensive patients was associated with endothelial dysfunction, which results in elevated plasma ET-1 levels.

Positive_regulation (results) of ET-1 in plasma associated with hypertension

7) Confidence 0.62 Published 2005 Journal Hypertens. Res. Section Abstract Doc Link 16555580 Disease Relevance 0.71 Pain Relevance 0.36

After induction of cardiopulmonary bypass, ET-1 levels increased significantly compared with preoperative values (P < 0.01).

Positive_regulation (increased) of ET-1

8) Confidence 0.61 Published 1996 Journal Cardiovasc Surg Section Abstract Doc Link 9013015 Disease Relevance 0.24 Pain Relevance 0.23

Although plasma ir-ET was composed mainly of big ET and endothelin-1 (ET-1) in normal subjects, that in acute myocardial infarction, chronic renal failure (CRF), essential hypertension, and vasospastic angina pectoris was characterized by an increase of high molecular ir-ET in addition to increases in big ET and ET-1.

Positive_regulation (increases) of ET-1 in plasma associated with angina, chronic renal failure, hypertension and myocardial infarction

9) Confidence 0.59 Published 1991 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1725426 Disease Relevance 0.66 Pain Relevance 0.10

We conclude that, regardless of the state of alertness, -/- mice develop salt-sensitive hypertension after prolonged feeding on HS, in part due to their inability to reduce PRA, whereas the specific renal upregulation of ecNOS and ET-1 in response to HS intake may be an ANP-independent adaptive adjustment aimed at improving kidney function and counteracting the pressor effect of salt.

Positive_regulation (upregulation) of ET-1 in kidney associated with hypertension

10) Confidence 0.59 Published 1998 Journal Am. J. Physiol. Section Abstract Doc Link 9458926 Disease Relevance 0.25 Pain Relevance 0.06

ET-1 levels immediately downstream from the plaque and ET-1 aortocoronary gradient increased significantly after the procedure, which was related to mechanical wall stress in patients only receiving balloons, but not in those undergoing stent percutaneous transluminal coronary angioplasty.

Positive_regulation (increased) of ET-1 in plaque associated with stress and percutaneous transluminal coronary angioplasty

11) Confidence 0.58 Published 1999 Journal Am. J. Cardiol. Section Abstract Doc Link 10569670 Disease Relevance 0.32 Pain Relevance 0.24

The possible algogenic effects of elevated serum endothelin levels in cardiac syndrome X were investigated in a case-control study that examined somatic pain perception in the forearm during submaximal effort tourniquet and cold immersion tests.

Spec (possible) Positive_regulation (elevated) of serum endothelin in forearm associated with pain, algogenic, syndrome and somatic pain

12) Confidence 0.51 Published 1997 Journal Am. J. Cardiol. Section Abstract Doc Link 9294999 Disease Relevance 0.51 Pain Relevance 0.42

Whether or not plasma ET-1 concentrations are elevated in patients developing clinically significant postoperative pulmonary hypertension requires further study.

Positive_regulation (elevated) of ET-1 in plasma

13) Confidence 0.50 Published 2000 Journal J. Cardiothorac. Vasc. Anesth. Section Body Doc Link 10794331 Disease Relevance 0 Pain Relevance 0

Hence, this test could provide a convenient in vivo endpoint for endothelin activity.

Positive_regulation (endpoint) of endothelin

14) Confidence 0.50 Published 1991 Journal Life Sci. Section Abstract Doc Link 1826753 Disease Relevance 0.09 Pain Relevance 0.16

That is, at equieffective doses, a 60-min prior i.p. injection of ET-1 blocked the behavioral response to a subsequent i.p. injection of ET-1 or PpQ, but not of ACh, whereas a 60-min prior injection of ACh or of PpQ had no effect on a subsequent i.p. injection of ACh, PpQ or ET-1.

Positive_regulation (injection) of ET-1

15) Confidence 0.48 Published 1996 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8764328 Disease Relevance 0.14 Pain Relevance 0.12

Here, we investigated whether TRPA1 is involved in endothelin-1 (ET-1)-induced spontaneous pain-like behavior in C57BL/6J mice.

Positive_regulation (induced) of endothelin-1 associated with pain and spontaneous pain

16) Confidence 0.48 Published 2010 Journal Neuroreport Section Abstract Doc Link 20042899 Disease Relevance 0.66 Pain Relevance 0.75

Here, we investigated whether TRPA1 is involved in endothelin-1 (ET-1)-induced spontaneous pain-like behavior in C57BL/6J mice.

Positive_regulation (induced) of ET-1 associated with pain and spontaneous pain

17) Confidence 0.48 Published 2010 Journal Neuroreport Section Abstract Doc Link 20042899 Disease Relevance 0.66 Pain Relevance 0.75

The plasma ET-1 level increased gradually during normal pregnancy as the pregnancy advanced, the levels (0.40 +/- 0.02 pmol/l, n = 45) being significantly (p less than 0.05) higher after 29 weeks of gestation than those (0.32 +/- 0.01 pmol/l, n = 30) before 28 weeks of gestation.

Positive_regulation (increased) of ET-1 in plasma

18) Confidence 0.48 Published 1990 Journal Gynecol. Endocrinol. Section Abstract Doc Link 2204252 Disease Relevance 0.22 Pain Relevance 0.22

We found that ET-1 was increased in the hypothalamus while no significant increase was observed in the midbrain, medulla and spinal cord.

Neg (no) Positive_regulation (increase) of ET-1 in medulla associated with medulla, midbrain and spinal cord

19) Confidence 0.47 Published 2005 Journal Neuroscience Section Abstract Doc Link 15664691 Disease Relevance 1.60 Pain Relevance 1.44

The level of endothelin-1 (ET-1), a major mediator regulating both the vascular [3,4] and the airway smooth muscle tone [5-7], has been reported to be elevated following the exposure of endothelial cells to hyperoxia [8], and also in different in vivo experimental models of acute lung injury [9,10].

Positive_regulation (elevated) of ET-1 in endothelial cells associated with hyperoxia and adult respiratory distress syndrome

20) Confidence 0.47 Published 2006 Journal Respir Res Section Body Doc Link PMC1475846 Disease Relevance 0.87 Pain Relevance 0

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