INT153907

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Context Info
Confidence 0.55
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 4
Disease Relevance 2.30
Pain Relevance 0.32

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Lpar1) plasma membrane (Lpar1) cytoplasm (Lpar1)
signal transducer activity (Lpar1)
Anatomy Link Frequency
skin 2
blood 1
germ cell 1
Lpar1 (Mus musculus)
Pain Link Frequency Relevance Heat
Inflammation 4 98.04 Very High Very High Very High
Neuropathic pain 25 92.68 High High
antagonist 45 75.44 Quite High
agonist 45 72.92 Quite High
fibrosis 27 5.00 Very Low Very Low Very Low
dorsal root ganglion 12 5.00 Very Low Very Low Very Low
Pain 12 5.00 Very Low Very Low Very Low
metalloproteinase 12 5.00 Very Low Very Low Very Low
Potency 9 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Alopecia 9 99.72 Very High Very High Very High
Targeted Disruption 48 98.60 Very High Very High Very High
INFLAMMATION 7 98.04 Very High Very High Very High
Male Infertility 6 97.50 Very High Very High Very High
Vasculitis 1 97.48 Very High Very High Very High
Thrombosis 13 96.68 Very High Very High Very High
Cancer 74 95.84 Very High Very High Very High
Neuropathic Pain 31 92.68 High High
Reprotox - General 1 3 91.84 High High
Apoptosis 45 91.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
LPA is present in the blood and other biological fluids at physiologically relevant concentrations and can likely be rapidly generated and degraded in different locations, for example at sites of inflammation, vascular injury and thrombosis or in the tumor micro environment.
Protein_catabolism (degraded) of LPA in blood associated with inflammation, cancer, vasculitis and thrombosis
1) Confidence 0.55 Published 2008 Journal Curr Drug Targets Section Abstract Doc Link 18691016 Disease Relevance 0.87 Pain Relevance 0.14
Of note is the observation that transgenic mice overexpressing lipid phosphate phosphatase-1 (LPP1/PAP2a), an ectoenzyme thought to degrade LPA, show hair growth defects that is consistent with LPP1-mediated degradation of LPA in the skin (Yue et al., 2004).
Protein_catabolism (degradation) of LPA in skin associated with targeted disruption and alopecia
2) Confidence 0.43 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.37 Pain Relevance 0.03
Similar azoospermia and reduced germ cell numbers were found in transgenic animals that overexpress lipid phosphate phosphatase, an enzyme that degrades LPA (Yue et al., 2004).
Protein_catabolism (degrades) of LPA in germ cell associated with targeted disruption and male infertility
3) Confidence 0.38 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.68 Pain Relevance 0.11
Of note is the observation that transgenic mice overexpressing lipid phosphate phosphatase-1 (LPP1/PAP2a), an ectoenzyme thought to degrade LPA, show hair growth defects that is consistent with LPP1-mediated degradation of LPA in the skin (Yue et al., 2004).
Protein_catabolism (degrade) of LPA in skin associated with targeted disruption and alopecia
4) Confidence 0.38 Published 2010 Journal British Journal of Pharmacology Section Body Doc Link PMC2989581 Disease Relevance 0.37 Pain Relevance 0.04

General Comments

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