INT153923

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Context Info
Confidence 0.00
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 4
Disease Relevance 0.89
Pain Relevance 1.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Msr1) oxidoreductase activity (Tdo2) plasma membrane (Msr1)
Anatomy Link Frequency
cortex 5
hypothalamus 1
striatum 1
hippocampus 1
Msr1 (Mus musculus)
Tdo2 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Hippocampus 4 97.88 Very High Very High Very High
antidepressant 12 87.68 High High
agonist 8 86.16 High High
fluoxetine 4 74.96 Quite High
Raphe 4 67.04 Quite High
Locus ceruleus 4 25.00 Low Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 12 88.28 High High
Targeted Disruption 4 59.60 Quite High
Stress 4 30.72 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
SR58611A (3 and 10 mg/kg, p.o.) increased the synthesis of 5-HT and tryptophan (Trp) levels in several rodent brain areas (cortex, hippocampus, hypothalamus, striatum).
SR58611A Positive_regulation (increased) of Gene_expression (synthesis) of tryptophan in cortex associated with hippocampus
1) Confidence 0.00 Published 2008 Journal Neuroscience Section Abstract Doc Link 18691638 Disease Relevance 0.22 Pain Relevance 0.32
SR58611A (3 and 10 mg/kg, p.o.) increased the synthesis of 5-HT and tryptophan (Trp) levels in several rodent brain areas (cortex, hippocampus, hypothalamus, striatum).
SR58611A Positive_regulation (increased) of in hypothalamus Gene_expression (synthesis) of tryptophan in cortex associated with hippocampus
2) Confidence 0.00 Published 2008 Journal Neuroscience Section Abstract Doc Link 18691638 Disease Relevance 0.22 Pain Relevance 0.32
SR58611A (3 and 10 mg/kg, p.o.) increased the synthesis of 5-HT and tryptophan (Trp) levels in several rodent brain areas (cortex, hippocampus, hypothalamus, striatum).
SR58611A Positive_regulation (increased) of in striatum Gene_expression (synthesis) of tryptophan in cortex associated with hippocampus
3) Confidence 0.00 Published 2008 Journal Neuroscience Section Abstract Doc Link 18691638 Disease Relevance 0.22 Pain Relevance 0.32
SR58611A (3 and 10 mg/kg, p.o.) increased the synthesis of 5-HT and tryptophan (Trp) levels in several rodent brain areas (cortex, hippocampus, hypothalamus, striatum).
SR58611A Positive_regulation (increased) of in hippocampus Gene_expression (synthesis) of tryptophan in cortex associated with hippocampus
4) Confidence 0.00 Published 2008 Journal Neuroscience Section Abstract Doc Link 18691638 Disease Relevance 0.22 Pain Relevance 0.32

General Comments

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