INT153940

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Context Info
Confidence 0.78
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 0.63
Pain Relevance 0.55

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

aging (Timp1) extracellular region (Timp1) proteinaceous extracellular matrix (Timp1)
Anatomy Link Frequency
ESCs 1
Timp1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
metalloproteinase 47 98.88 Very High Very High Very High
fibrosis 30 93.44 High High
Angina 3 79.88 Quite High
Dismenorea 2 50.00 Quite Low
Inflammatory marker 23 43.88 Quite Low
Inflammation 14 31.80 Quite Low
tolerance 12 5.00 Very Low Very Low Very Low
cytokine 2 5.00 Very Low Very Low Very Low
aspirin 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cirrhosis 30 94.08 High High
Fibrosis 21 91.36 High High
Angina 3 79.88 Quite High
Dysmenorrhea 2 68.56 Quite High
Diabetes Mellitus 24 62.44 Quite High
Vomiting 2 58.32 Quite High
Body Weight 2 51.68 Quite High
Injury 9 47.40 Quite Low
INFLAMMATION 39 43.56 Quite Low
Metabolic Disorder 1 36.44 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
TIMPs are secreted proteins that complex with MMPs to modulate activity and activation (5).
Localization (secreted) of TIMP associated with metalloproteinase
1) Confidence 0.78 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2844613 Disease Relevance 0.31 Pain Relevance 0.42
, IL-6, sCD40L, IL-8, MMP-9, TIMP-1, IL-18, and adiponectin.
Localization (sCD40L) of TIMP-1
2) Confidence 0.18 Published 2010 Journal Cardiovasc Diabetol Section Body Doc Link PMC2940874 Disease Relevance 0.26 Pain Relevance 0.14
MMP-2 (median 7.3 vs. 3.5 ng/mL) and TIMP-1 (median 12.1 vs. 3.9 ng/mL), but not MMP-9 and TIMP-2, secreted by ESCs in women with adenomyosis were much higher than those in women without adenomyosis.
Localization (secreted) of TIMP-1 in ESCs
3) Confidence 0.10 Published 2009 Journal Fertil. Steril. Section Body Doc Link 18692810 Disease Relevance 0.07 Pain Relevance 0

General Comments

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