INT153946

Context Info Confidence 0.66 First Reported 2008 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 8 Total Number 10 Disease Relevance 4.83 Pain Relevance 2.93

transport (Slc17a5) cytoplasmic membrane-bounded vesicle (Slc17a5) plasma membrane (Slc17a5) transmembrane transport (Slc17a5) lysosome (Slc17a5)

Anatomy Link Frequency liver 4 blood 1 Slc17a5 (Mus musculus)

Pain Link Frequency Relevance Heat ischemia 208 99.92 Paracetamol 47 98.60 Inflammation 30 97.04 cva 12 84.16 tolerance 4 79.32 cytokine 12 70.20 withdrawal 2 62.40 anesthesia 7 37.32 Osteoarthritis 46 5.00 cINOD 24 5.00

Disease Link Frequency Relevance Heat Hepatotoxicity 24 100.00 Cv Unclassified Under Development 207 99.92 Injury 112 99.18 Pressure And Volume Under Development 12 97.92 Pneumonia 1 97.04 Toxicity 10 95.36 Necrosis 14 93.64 Hepatitis 3 87.76 Stress 49 85.68 Cv General 3 Under Development 16 84.16

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Elevation of serum ALT and AST activities, decrease of reduced glutathione levels and histopathological liver changes were observed to the same extents in both APAP-treated groups.

Localization (decrease) of AST in liver associated with paracetamol

1) Confidence 0.66 Published 2009 Journal Toxicology Section Abstract Doc Link 19576946 Disease Relevance 0.22 Pain Relevance 0.71

However, a significant inhibition (p<0.05) in the elevation of AST and ALT was observed in mice that received UBG and GIBG compared with APAP-treated mice.

Localization (elevation) of AST associated with paracetamol

2) Confidence 0.59 Published 2009 Journal Chem. Biol. Interact. Section Abstract Doc Link 19109935 Disease Relevance 0.68 Pain Relevance 0.77

It was shown that PAR significantly increased serum ALT, AST, ALP, liver MDA levels and significantly decreased liver GSH-Px activity, when compared to the control group (Group 1).

Localization (increased) of AST in liver

3) Confidence 0.50 Published 2009 Journal Exp. Toxicol. Pathol. Section Abstract Doc Link 18693095 Disease Relevance 0.16 Pain Relevance 0.16

Asparate 2-oxoglutarate aminotransferase (AST), alanine 2-oxoglutarate aminotransferase (ALT), blood urea nitrogen (BUN), free cholesterol, triglyceride, non-esterified fatty acid, and LDL-cholesterol were measured with a Shimadzu CL8000 Clinical Chemistry Analyzer (Shimadzu, Ltd., Tokyo, Japan).

Localization (aminotransferase) of AST in blood

4) Confidence 0.14 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2266061 Disease Relevance 0.37 Pain Relevance 0.11

The time to normalization for ALT/AST values > 5 × ULN ranged between 4 and 132 days.

Localization (normalization) of AST

5) Confidence 0.13 Published 2008 Journal BMC Musculoskelet Disord Section Body Doc Link PMC2322990 Disease Relevance 0.08 Pain Relevance 0.04

AST release occurred earlier (0.5–1.5?

Localization (release) of AST

6) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010695 Disease Relevance 1.20 Pain Relevance 0.40

MIF, and AST release also moderately correlated (r = .4901, P < .0001) (Figure 6(f)).

Localization (release) of AST

7) Confidence 0.06 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010695 Disease Relevance 0.49 Pain Relevance 0.22

The kinetic of the HMGB1 translocation was in parallel to the overall injury of the organ graft as demonstrated by a release of liver damage markers (AST and ALT) as well as an increase in proteins in the effluent as demonstrated by a silver stain in a polyacrylamide gel.

Localization (release) of AST in liver associated with injury and hepatotoxicity

8) Confidence 0.05 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC3010695 Disease Relevance 0.61 Pain Relevance 0.17

AST release was reduced significantly more by treatment with SNO-HSA-OA5 than with SNO-HSA-OA3 120 min after reperfusion (Fig. 1A).

Localization (release) of AST

9) Confidence 0.04 Published 2008 Journal The Journal of Biological Chemistry Section Body Doc Link PMC2596408 Disease Relevance 0.44 Pain Relevance 0.09

CCl4-induced hepatic injuries are commonly used as models for the screening of hepatoprotective plant extract and the extent of hepatic damage is assessed by the level of released cytosolic transaminases including ALT and AST in circulation.[38] When administrated prophylacticaly, methanol extract exhibited protection against CCl4-induced liver injuries as manifested by the reduction of toxin-mediated rise in serum enzymes in rats.

Localization (released) of AST in liver associated with injury

10) Confidence 0.02 Published 2010 Journal Pharmacognosy Magazine Section Body Doc Link PMC2900060 Disease Relevance 0.58 Pain Relevance 0.28

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