INT153959

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Context Info
Confidence 0.80
First Reported 2006
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 8
Total Number 8
Disease Relevance 4.07
Pain Relevance 6.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

plasma membrane (GRIN1)
Anatomy Link Frequency
urethra 2
spinal 1
RVM 1
external 1
GRIN1 (Homo sapiens)
Pain Link Frequency Relevance Heat
nMDA receptor 24 100.00 Very High Very High Very High
excitatory amino acid 2 99.80 Very High Very High Very High
Rostral ventromedial medulla 5 99.70 Very High Very High Very High
central sensitization 50 99.44 Very High Very High Very High
Spinal cord 47 99.20 Very High Very High Very High
nud 5 99.14 Very High Very High Very High
Hyperalgesia 54 99.04 Very High Very High Very High
Cancer pain 1 98.92 Very High Very High Very High
Neuropathic pain 60 98.28 Very High Very High Very High
Acupuncture 10 97.98 Very High Very High Very High
Disease Link Frequency Relevance Heat
Dyspepsia 5 99.14 Very High Very High Very High
Hyperalgesia 67 99.04 Very High Very High Very High
Cancer Pain 1 98.92 Very High Very High Very High
Neuropathic Pain 90 98.28 Very High Very High Very High
Stress Incontinence 15 95.60 Very High Very High Very High
Referred Pain 3 94.64 High High
Low Back Pain 3 93.64 High High
Pain 26 90.88 High High
Nociception 40 90.24 High High
Injury 26 90.24 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Altogether, these data indicate that the EA-mediated attenuation of chronic visceral hypersensitivity is correlated with the down-regulation of NMDA receptors phosphorylation at the spinal level.
Phosphorylation (phosphorylation) of NMDA in spinal associated with nmda receptor, nud and acupuncture
1) Confidence 0.80 Published 2008 Journal Life Sci. Section Abstract Doc Link 18694764 Disease Relevance 0.55 Pain Relevance 1.05
The mechanism of the increase in responses to excitatory amino acids includes phosphorylation of NR1 subunits of NMDA receptors and GluR1 subunits of AMPA receptors.
Phosphorylation (phosphorylation) of NR1 associated with nmda receptor and excitatory amino acid
2) Confidence 0.80 Published 2009 Journal Exp Brain Res Section Abstract Doc Link 19294370 Disease Relevance 0.88 Pain Relevance 1.53
All these results suggest that EphBR-ephrinB interactions, which provoke Src-family kinase-dependent NMDAR NR2B phosphorylation at the lumbosacral spinal cord level, are involved in cross-organ sensitization, contributing to the development of viscero-visceral referred pain between the bowel and the urethra.
Phosphorylation (phosphorylation) of NMDAR in urethra associated with stress incontinence, referred pain and spinal cord
3) Confidence 0.80 Published 2010 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 19864302 Disease Relevance 0.55 Pain Relevance 0.29
Since the activation of NMDA receptors is important for the initiation and maintenance of central sensitization following intradermal injection of capsaicin [53], the inhibitors of PP2A may prolong the duration of central sensitization by allowing a long lasting phosphorylation of NMDA receptors.
Phosphorylation (phosphorylation) of NMDA associated with qutenza, central sensitization and nmda receptor
4) Confidence 0.80 Published 2006 Journal Mol Pain Section Body Doc Link PMC1559591 Disease Relevance 0 Pain Relevance 0.57
To test whether Src-family non-receptor tyrosine kinase-dependent glutamatergic N-methyl-d-aspartate receptor (NMDAR) NR2B subunit phosphorylation underlies lumbosacral spinal EphBR activation to mediate cross-organ sensitization between the colon and the urethra, external urethra sphincter electromyogram activity evoked by pelvic nerve stimulation and protein expression in the lumbosacral (L6-S2) dorsal horn were studied before and after intracolonic mustard oil (MO) instillation.
Phosphorylation (phosphorylation) of NMDAR in external associated with stress incontinence and dorsal horn
5) Confidence 0.61 Published 2010 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 19864302 Disease Relevance 0.43 Pain Relevance 0.17
Protein tyrosine phosphorylation regulates NMDA channel receptor activity.
Phosphorylation (phosphorylation) of NMDA
6) Confidence 0.61 Published 2009 Journal Mol Pain Section Body Doc Link PMC2809057 Disease Relevance 0.50 Pain Relevance 1.27
into RVM increases NR1 phosphorylation of NMDA receptors and produces hyperalgesia, which is reversed by an NMDA antagonist.
Phosphorylation (phosphorylation) of NMDA in RVM associated with hyperalgesia, antagonist, nmda receptor and rostral ventromedial medulla
7) Confidence 0.61 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2861665 Disease Relevance 0.67 Pain Relevance 1.14
To test whether Src-family non-receptor tyrosine kinase-dependent glutamatergic N-methyl-d-aspartate receptor (NMDAR) NR2B subunit phosphorylation underlies lumbosacral spinal EphBR activation to mediate cross-organ sensitization between the colon and the urethra, external urethra sphincter electromyogram activity evoked by pelvic nerve stimulation and protein expression in the lumbosacral (L6-S2) dorsal horn were studied before and after intracolonic mustard oil (MO) instillation.
Phosphorylation (phosphorylation) of NMDAR in urethra associated with stress incontinence and dorsal horn
8) Confidence 0.21 Published 2010 Journal Am. J. Physiol. Renal Physiol. Section Abstract Doc Link 19864302 Disease Relevance 0.43 Pain Relevance 0.17

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