INT15400

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Context Info
Confidence 0.22
First Reported 1987
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 5
Total Number 6
Disease Relevance 1.02
Pain Relevance 1.74

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
Liver 1
heart 1
urine 1
Hrtrt1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
antagonist 8 99.52 Very High Very High Very High
narcan 15 99.24 Very High Very High Very High
noradrenaline 5 98.48 Very High Very High Very High
palliative 1 93.56 High High
Morphine 6 88.84 High High
Thalamus 44 85.40 High High
Clonidine 6 77.12 Quite High
agonist 4 62.32 Quite High
opiate 1 51.32 Quite High
anesthesia 9 25.00 Low Low
Disease Link Frequency Relevance Heat
Hyperlipidemia 1 95.20 Very High Very High Very High
Disorder Of Lipid Metabolism 2 92.20 High High
Increased Venous Pressure Under Development 1 83.20 Quite High
Hypotension 8 80.80 Quite High
Disease 1 79.84 Quite High
Hyperlipoproteinemia Type Ii 5 75.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the SB atria, naloxone caused no change in the dose-related increases in atrial tension and heart rate when combined with the lower dose of noradrenaline but decreased AT when combined with 12 microM noradrenaline, compared with when this dose of noradrenaline was given alone.
Positive_regulation (increases) of rate in heart associated with noradrenaline and narcan
1) Confidence 0.22 Published 1990 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2322896 Disease Relevance 0.07 Pain Relevance 1.14
In conscious rats, when administered intracerebroventricularly (i.c.v.) in doses of 0.3, 1 and 3 micrograms/kg/min for 30 min, all the three Ca-antagonists induced dose-dependent increases in mean arterial pressure (MAP) and pulse rate (PR), whereas nicardipine administered intravenously (i.v.) caused a decrease in MAP and an increase in PR.
Positive_regulation (increases) of rate associated with antagonist
2) Confidence 0.05 Published 1987 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 3576611 Disease Relevance 0.15 Pain Relevance 0.40
The population firing-rate models are formulated as nonlinear Volterra integral
                   equations [5],[14],(18)where  is a temporal coupling kernel, and  is the temporal convolution given by(19)
Positive_regulation (formulated) of firing-rate
3) Confidence 0.03 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2653726 Disease Relevance 0 Pain Relevance 0
Very different population firing-rate models are identified for the intracortical
               circuits, i.e., the spread of population activity from layer 4 to supragranular
               (layer 2/3) and infragranular (layer 5) layers. 
Positive_regulation (population) of firing-rate
4) Confidence 0.03 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2653726 Disease Relevance 0 Pain Relevance 0.11
Liver transplantation restores LDL receptor activity to over 60% of normal, which results in an increase in the fractional catabolic rate (FCR) and a decrease in the synthetic rate of LDL apo B-100.
Positive_regulation (increase) of rate in Liver
5) Confidence 0.00 Published 1989 Journal Arteriosclerosis Section Abstract Doc Link 2643427 Disease Relevance 0.72 Pain Relevance 0.09
The significant increase in urine flow rate (UF) was associated with a marked reduction in urine osmolarity (Uosm) during ET-3 infusion, but urinary excretion of sodium (UNaV) remained unchanged.
Positive_regulation (increase) of rate in urine
6) Confidence 0.00 Published 1991 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1725372 Disease Relevance 0.08 Pain Relevance 0

General Comments

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