INT15400

Context Info Confidence 0.22 First Reported 1987 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 5 Total Number 6 Disease Relevance 1.02 Pain Relevance 1.74

Anatomy Link Frequency Liver 1 heart 1 urine 1 Hrtrt1 (Rattus norvegicus)

Pain Link Frequency Relevance Heat antagonist 8 99.52 narcan 15 99.24 noradrenaline 5 98.48 palliative 1 93.56 Morphine 6 88.84 Thalamus 44 85.40 Clonidine 6 77.12 agonist 4 62.32 opiate 1 51.32 anesthesia 9 25.00

Disease Link Frequency Relevance Heat Hyperlipidemia 1 95.20 Disorder Of Lipid Metabolism 2 92.20 Increased Venous Pressure Under Development 1 83.20 Hypotension 8 80.80 Disease 1 79.84 Hyperlipoproteinemia Type Ii 5 75.40

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In the SB atria, naloxone caused no change in the dose-related increases in atrial tension and heart rate when combined with the lower dose of noradrenaline but decreased AT when combined with 12 microM noradrenaline, compared with when this dose of noradrenaline was given alone.

Positive_regulation (increases) of rate in heart associated with noradrenaline and narcan

1) Confidence 0.22 Published 1990 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2322896 Disease Relevance 0.07 Pain Relevance 1.14

In conscious rats, when administered intracerebroventricularly (i.c.v.) in doses of 0.3, 1 and 3 micrograms/kg/min for 30 min, all the three Ca-antagonists induced dose-dependent increases in mean arterial pressure (MAP) and pulse rate (PR), whereas nicardipine administered intravenously (i.v.) caused a decrease in MAP and an increase in PR.

Positive_regulation (increases) of rate associated with antagonist

2) Confidence 0.05 Published 1987 Journal Tohoku J. Exp. Med. Section Abstract Doc Link 3576611 Disease Relevance 0.15 Pain Relevance 0.40

The population firing-rate models are formulated as nonlinear Volterra integral equations [5],[14],(18)where is a temporal coupling kernel, and is the temporal convolution given by(19)

Positive_regulation (formulated) of firing-rate

3) Confidence 0.03 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2653726 Disease Relevance 0 Pain Relevance 0

Very different population firing-rate models are identified for the intracortical circuits, i.e., the spread of population activity from layer 4 to supragranular (layer 2/3) and infragranular (layer 5) layers.

Positive_regulation (population) of firing-rate

4) Confidence 0.03 Published 2009 Journal PLoS Computational Biology Section Body Doc Link PMC2653726 Disease Relevance 0 Pain Relevance 0.11

Liver transplantation restores LDL receptor activity to over 60% of normal, which results in an increase in the fractional catabolic rate (FCR) and a decrease in the synthetic rate of LDL apo B-100.

Positive_regulation (increase) of rate in Liver

5) Confidence 0.00 Published 1989 Journal Arteriosclerosis Section Abstract Doc Link 2643427 Disease Relevance 0.72 Pain Relevance 0.09

The significant increase in urine flow rate (UF) was associated with a marked reduction in urine osmolarity (Uosm) during ET-3 infusion, but urinary excretion of sodium (UNaV) remained unchanged.

Positive_regulation (increase) of rate in urine

6) Confidence 0.00 Published 1991 Journal J. Cardiovasc. Pharmacol. Section Abstract Doc Link 1725372 Disease Relevance 0.08 Pain Relevance 0

General Comments

This test has worked.