INT154007

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Context Info
Confidence 0.56
First Reported 2005
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 46
Total Number 56
Disease Relevance 15.28
Pain Relevance 28.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neurons 4
striatum 3
dorsal 2
brain 2
ventral 2
da (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 8033 100.00 Very High Very High Very High
midbrain 287 100.00 Very High Very High Very High
substance P 1 100.00 Very High Very High Very High
medulla 51 99.98 Very High Very High Very High
Substantia nigra 74 99.36 Very High Very High Very High
narcan 2 99.10 Very High Very High Very High
antagonist 106 98.92 Very High Very High Very High
opiate 1 98.70 Very High Very High Very High
addiction 92 98.54 Very High Very High Very High
Nucleus accumbens 81 98.16 Very High Very High Very High
Disease Link Frequency Relevance Heat
Parkinson's Disease 1782 100.00 Very High Very High Very High
Congenital Anomalies 71 99.68 Very High Very High Very High
Disease 989 99.60 Very High Very High Very High
Neurologic Manifestations 40 98.84 Very High Very High Very High
Tremor 400 97.16 Very High Very High Very High
Neurodegenerative Disease 146 92.36 High High
Urological Neuroanatomy 160 91.84 High High
Pathologic Processes 80 91.76 High High
Aging 166 91.20 High High
Death 102 89.32 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, avoidance of an aversively-paired stimulus (the opiate antagonist naloxone) was associated with enhanced extracellular DA levels, and also the balance between DA and 5-HT responses.
Gene_expression (levels) of DA associated with dopamine, antagonist, narcan and opiate
1) Confidence 0.56 Published 2009 Journal Eur. J. Neurosci. Section Abstract Doc Link 19245370 Disease Relevance 0 Pain Relevance 1.04
Basal DA release increased 2.4-fold between week 3 (1st DA release experiment) and week 4 in vitro (3rd DA release experiment), DA tissue levels increased 1.6-fold and DA release expressed as a percentage of total DA (medium + tissue contents) increased from 20% to 34% during this growth period in vitro.
Gene_expression (expressed) of DA associated with dopamine
2) Confidence 0.48 Published 2008 Journal Eur. J. Neurosci. Section Abstract Doc Link 18702728 Disease Relevance 0.07 Pain Relevance 0.91
With loss of the major intracellular storage pool of DA in DAT-KO mice, both the intracellular and extracellular levels of DA in the striatum become critically dependent upon ongoing DA synthesis.
Gene_expression (synthesis) of DA in striatum associated with dopamine
3) Confidence 0.24 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.07 Pain Relevance 0.59
It is likely that the newly synthesized DA does not contribute directly to the large storage pool of DA in nigrostriatal terminals, but rather contributes to it indirectly via released and recycled DA.
Gene_expression (synthesized) of DA associated with dopamine
4) Confidence 0.24 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.09 Pain Relevance 0.78
Unlike normal animals, these mice demonstrate remarkable dependence of the remaining DA on ongoing synthesis, and pharmacologic blockade of DA synthesis in DAT-KO mice provides an effective approach to eliminate DA acutely [12,13].
Gene_expression (synthesis) of DA associated with addiction and dopamine
5) Confidence 0.24 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.25 Pain Relevance 0.65
As a result, inhibition of DA synthesis essentially eliminates striatal DA in these mice leading to the extreme behavioral manifestations.
Gene_expression (synthesis) of DA associated with dopamine
6) Confidence 0.24 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.15 Pain Relevance 0.67
It is generally assumed that the intraneuronal storage of DA is replenished primarily from newly synthesized DA with some contribution from recycled DA.
Gene_expression (synthesized) of DA associated with dopamine
7) Confidence 0.24 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.07 Pain Relevance 0.73
DA is synthesized from tyrosine by the rate-limiting enzyme tyrosine hydroxylase (TH), to produce L-DOPA which is quickly decarboxylated by L-aromatic acid decarboxylase (L-AADC) to DA [1,3].
Gene_expression (synthesized) of DA associated with dopamine
8) Confidence 0.24 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.07 Pain Relevance 0.84
Thus, both intracellular and extracellular DA levels in the striatum of DAT-KO mice are critically dependent upon ongoing synthesis.


Gene_expression (levels) of DA in striatum associated with dopamine
9) Confidence 0.24 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.22 Pain Relevance 0.43
Although it is likely that the lack of locomotor effects of these drugs in DDD mice is related to an unprecedented level of DA depletion in these mice, it should be emphasized that in our studies only a few doses or combinations of drugs were tested.
Gene_expression (depletion) of DA associated with dopamine
10) Confidence 0.21 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.29 Pain Relevance 0.32
This may explain why certain behavioral manifestations of DA deficiency such as rigidity and akinesia may be more robust in DDD mice, whereas tremor was not observed in DD mutants [3,76].
Gene_expression (deficiency) of DA associated with tremor and dopamine
11) Confidence 0.21 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.23 Pain Relevance 0.60
In DD mutant mice, a lack of TH resulting in permanently decreased DA signaling, as well as daily treatments with L-DOPA render these mice extremely supersensitive to DA stimulations [81], whereas excessive DA signaling in DAT-KO mice results in compensatory down-regulation (but nonuniform) of DA receptors [11,13].
Gene_expression (signaling) of DA associated with dopamine
12) Confidence 0.21 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.23 Pain Relevance 0.61
At the same time, a second treatment 2 h later by the same dose of the drug failed to induce locomotion in DD mice suggesting that this effect is dependent upon residual (after L-DOPA administration) DA which might be depleted by the first treatment with the drug [76].
Gene_expression (administration) of DA associated with dopamine
13) Confidence 0.21 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0 Pain Relevance 0.48
Thus, it is virtually impossible that the observed effects of MDMA and other amphetamines in DDD mice are directly related to DA transmission.
Gene_expression (transmission) of DA associated with dopamine
14) Confidence 0.21 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.13 Pain Relevance 0.64
MT to produce various degrees of DA depletion, these mice can also be employed to find novel approaches to restore movement under conditions of partially impaired DA transmission that might be more relevant to most PD cases.
Gene_expression (produce) of DA associated with parkinson's disease and dopamine
15) Confidence 0.21 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.40 Pain Relevance 0.60
This selective depletion of DA in dopaminergic terminals of DAT-KO mice, as well as analogous depletion observed in mice lacking NET [51] or serotonin transporter [52] with NE and serotonin (5-HT), respectively, reflects the critical role of transporter-mediated recycling in the maintenance of intracellular storage pools [13].
Gene_expression (depletion) of DA associated with dopamine and serotonin
16) Confidence 0.21 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.15 Pain Relevance 0.70
This poor behavioral expression of PD-related behaviors generally results in high level of false-positive results in drug screening tests in general, and particularly in those attempted to identify non-DA therapies [72].
Gene_expression (expression) of DA associated with parkinson's disease and dopamine
17) Confidence 0.21 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.74 Pain Relevance 0.47
MT treatment essentially eliminated extracellular DA levels in DAT-KO mice (Figure 1F), whereas only a partial decrease was observed in WT mice.
Gene_expression (levels) of DA associated with dopamine
18) Confidence 0.21 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.18 Pain Relevance 0.42
However, in DDD mice, there is only a minimal amount of DA remaining (<0.2%) and the lack of the DAT precludes the possibility of amphetamine-mediated DA efflux.
Neg (lack) Gene_expression (lack) of DA associated with dopamine
19) Confidence 0.21 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0 Pain Relevance 0.49
Major DA systems in the brain originate from brainstem DA neurons located in the substantia nigra pars compacta (SNc) and the ventral tegmental area (VTA).
Gene_expression (systems) of DA in brain associated with ventral tegmentum, medulla, dopamine and substantia nigra
20) Confidence 0.21 Published 2005 Journal PLoS Biology Section Body Doc Link PMC1181539 Disease Relevance 0.09 Pain Relevance 0.56

General Comments

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