INT154019

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Context Info
Confidence 0.61
First Reported 2007
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.07
Pain Relevance 0.67

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Jun) nucleus (Jun) DNA binding (Jun)
transcription factor binding (Jun)
Jun (Mus musculus)
Pain Link Frequency Relevance Heat
Gabapentin 5 95.20 Very High Very High Very High
metalloproteinase 25 87.36 High High
cytokine 29 85.32 High High
Inflammation 24 69.56 Quite High
rheumatoid arthritis 52 50.00 Quite Low
chemokine 5 5.00 Very Low Very Low Very Low
Arthritis 5 5.00 Very Low Very Low Very Low
methotrexate 4 5.00 Very Low Very Low Very Low
antagonist 2 5.00 Very Low Very Low Very Low
COX-2 inhibitor 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 25 69.56 Quite High
Rheumatoid Arthritis 52 50.00 Quite Low
Apoptosis 28 5.00 Very Low Very Low Very Low
Disease 11 5.00 Very Low Very Low Very Low
Severe Combined Immunodeficiency 8 5.00 Very Low Very Low Very Low
Adhesions 7 5.00 Very Low Very Low Very Low
Cancer 7 5.00 Very Low Very Low Very Low
Hypoxia 4 5.00 Very Low Very Low Very Low
Arthritis 4 5.00 Very Low Very Low Very Low
Metastasis 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the sustained-release tablet did not disintegrate and had slow drug release characteristics, it showed similar pharmacokinetic parameters to the immediate-release tablet, which rapidly disintegrated and showed fast drug release.
Protein_catabolism (disintegrated) of immediate-release
1) Confidence 0.61 Published 2008 Journal Arch. Pharm. Res. Section Abstract Doc Link 18704335 Disease Relevance 0 Pain Relevance 0.41
Stimulation of MAPK pathways result in the expression of Jun and Fos proteins, which form homodimers and heterdimers to build up the transcription factor activator protein-1.
Protein_catabolism (proteins) of Jun
2) Confidence 0.10 Published 2007 Journal Arthritis Res Ther Section Body Doc Link PMC2246247 Disease Relevance 0.07 Pain Relevance 0.27

General Comments

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