INT154048

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Context Info
Confidence 0.43
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 5
Total Number 9
Disease Relevance 4.43
Pain Relevance 1.22

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk8) signal transduction (Mapk8) mitochondrion (Mapk8)
nucleus (Mapk8) kinase activity (Mapk8) cytoplasm (Mapk8)
Anatomy Link Frequency
hepatocytes 2
liver 2
adipocytes 2
Mapk8 (Mus musculus)
Pain Link Frequency Relevance Heat
addiction 5 99.32 Very High Very High Very High
Pain 2 99.22 Very High Very High Very High
Inflammation 96 97.46 Very High Very High Very High
Paracetamol 6 97.12 Very High Very High Very High
Peripheral sensitization 2 93.44 High High
Hyperalgesia 4 85.28 High High
nMDA receptor 1 83.88 Quite High
Inflammatory response 13 73.36 Quite High
central sensitization 1 66.60 Quite High
Inflammatory mediators 5 63.28 Quite High
Disease Link Frequency Relevance Heat
Pain 2 99.22 Very High Very High Very High
Obesity 94 98.56 Very High Very High Very High
Injury 50 98.28 Very High Very High Very High
INFLAMMATION 113 97.46 Very High Very High Very High
Hepatitis 7 97.12 Very High Very High Very High
Apoptosis 11 95.04 Very High Very High Very High
Targeted Disruption 18 92.64 High High
Airway Obstruction 20 91.20 High High
Liver Disease 4 88.48 High High
Insulin Resistance 11 86.56 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This elevated expression was abrogated by JNK1 mutation and the JNK inhibitor, indicating the dependence of MUC5AC expression on JNK activity.
Negative_regulation (inhibitor) of Gene_expression (mutation) of JNK1 associated with addiction
1) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.53 Pain Relevance 0.05
The pathological scores 4 h and 24 h after smoke inhalation was significantly decreased by use of the JNK inhibitor or JNK -/-.
Negative_regulation (decreased) of Gene_expression (use) of JNK
2) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.17 Pain Relevance 0
The pathological scores 4 h and 24 h after smoke inhalation was significantly decreased by use of the JNK inhibitor or JNK -/-.
Negative_regulation (decreased) of Gene_expression (use) of JNK
3) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.17 Pain Relevance 0
The pathological scores 4 h and 24 h after smoke inhalation was significantly decreased by use of the JNK inhibitor or JNK -/-.
Negative_regulation (inhibitor) of Gene_expression (use) of JNK
4) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.17 Pain Relevance 0
The pathological scores 4 h and 24 h after smoke inhalation was significantly decreased by use of the JNK inhibitor or JNK -/-.
Negative_regulation (inhibitor) of Gene_expression (use) of JNK
5) Confidence 0.43 Published 2010 Journal Respir Res Section Body Doc Link PMC3014901 Disease Relevance 0.17 Pain Relevance 0
Furthermore, mice lacking both JNK1 and 2 expression in hepatocytes exhibit the same degree of injury in the development of hepatitis as control mice do, whereas mice without JNK1/2 in the hematopoietic compartment exhibit a profound defect in hepatitis that is associated with a markedly reduced expression of TNF-?.
Negative_regulation (lacking) of Gene_expression (expression) of JNK1 in hepatocytes associated with injury and hepatitis
6) Confidence 0.39 Published 2010 Journal Gastroenterology Research and Practice Section Body Doc Link PMC2995932 Disease Relevance 1.57 Pain Relevance 0.20
-mediated suppression of adiponectin in adipocytes; however, the mechanisms of their inhibitory effects are different; 6-gingerol inhibits JNK signaling pathways in TNF-?
Negative_regulation (inhibits) of Gene_expression (pathways) of JNK in adipocytes associated with obesity
7) Confidence 0.07 Published 2010 Journal Mediators of Inflammation Section Body Doc Link PMC2876247 Disease Relevance 0.96 Pain Relevance 0.25
It also decreased AAP-induced liver injury, accompanied by decreased expression of pJNK, Bax and tBid in the liver.
Negative_regulation (decreased) of Gene_expression (expression) of pJNK in liver
8) Confidence 0.06 Published 2010 Journal J. Sci. Food Agric. Section Body Doc Link 20355050 Disease Relevance 0.09 Pain Relevance 0
Furthermore, in formalin inflammation pain model, pre-inhibition of EphBs receptors by the injection of EphB1-Fc reduces pain behavior, which is accompanied by the decreased expression of peripheral p-p38, pERK and pJNK.
Negative_regulation (decreased) of Gene_expression (expression) of pJNK associated with pain and inflammation
9) Confidence 0.05 Published 2008 Journal Pain Section Abstract Doc Link 18706764 Disease Relevance 0.59 Pain Relevance 0.72

General Comments

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