INT154069

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Context Info
Confidence 0.40
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.90

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endoplasmic reticulum (Ugt1a6) enzyme binding (Ugt1a6) protein complex (Ugt1a6)
Ugt1a6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Paracetamol 12 99.40 Very High Very High Very High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
None of the 3 inhibitors of APAP glucuronidation were able to alter the expression of UGT1A6, UGT1A7 and UGT1A8 (the major isoforms responsible for APAP glucuronidation in the rat), however, their efficacy at inhibiting APAP glucuronidation was proportional to their capacity to deplete UDP-glucuronic acid (UDPGA).
Regulation (alter) of Gene_expression (expression) of UGT1A6 associated with paracetamol
1) Confidence 0.40 Published 2008 Journal Toxicol. Appl. Pharmacol. Section Abstract Doc Link 18708084 Disease Relevance 0 Pain Relevance 0.90

General Comments

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